2V9V
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2WFJ
| Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A. | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, CYCLOSPORIN A, ... | 著者 | Stegmann, C.M, Sheldrick, G.M, Wahl, M.C. | 登録日 | 2009-04-06 | 公開日 | 2009-06-16 | 最終更新日 | 2019-05-22 | 実験手法 | X-RAY DIFFRACTION (0.75 Å) | 主引用文献 | The Thermodynamic Influence of Trapped Water Molecules on a Protein-Ligand Interaction. Angew.Chem.Int.Ed.Engl., 48, 2009
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2WFI
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2X7K
| The crystal structure of PPIL1 in complex with cyclosporine A suggests a binding mode for SKIP | 分子名称: | CADMIUM ION, CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 1, ... | 著者 | Stegmann, C.M, Luehrmann, R, Wahl, M.C. | 登録日 | 2010-03-01 | 公開日 | 2010-03-23 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | The Crystal Structure of Ppil1 Bound to Cyclosporine a Suggests a Binding Mode for a Linear Epitope of the Skip Protein. Plos One, 5, 2010
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8ALZ
| Cryo-EM structure of ASCC3 in complex with ASC1 | 分子名称: | Activating signal cointegrator 1, Activating signal cointegrator 1 complex subunit 3, ZINC ION | 著者 | Jia, J, Hilal, T, Loll, B, Wahl, M.C. | 登録日 | 2022-08-01 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structure of ASCC3 in complex with ASC1 Nat Commun, 2023
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7OS1
| Cryo-EM structure of Brr2 in complex with Fbp21 | 分子名称: | U5 small nuclear ribonucleoprotein 200 kDa helicase, WW domain-binding protein 4 | 著者 | Bergfort, A, Hilal, T, Weber, G, Wahl, M.C. | 登録日 | 2021-06-07 | 公開日 | 2022-02-23 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling. Nucleic Acids Res., 50, 2022
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7OS2
| Cryo-EM structure of Brr2 in complex with Jab1/MPN and C9ORF78 | 分子名称: | Pre-mRNA-processing-splicing factor 8, Telomere length and silencing protein 1 homolog, U5 small nuclear ribonucleoprotein 200 kDa helicase | 著者 | Bergfort, A, Hilal, T, Weber, G, Wahl, M.C. | 登録日 | 2021-06-07 | 公開日 | 2022-02-23 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling. Nucleic Acids Res., 50, 2022
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8BCC
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 39 | 分子名称: | 1,2-ETHANEDIOL, 3-oxidanylbenzenesulfonamide, Pre-mRNA-processing-splicing factor 8, ... | 著者 | Vester, K, Loll, B, Wahl, M.C. | 登録日 | 2022-10-15 | 公開日 | 2023-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2. Acta Crystallogr D Struct Biol, 79, 2023
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8BCG
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 86 | 分子名称: | 1,2-ETHANEDIOL, 4-chloranyl-~{N}-methoxy-~{N}-methyl-benzenesulfonamide, Pre-mRNA-processing-splicing factor 8, ... | 著者 | Vester, K, Loll, B, Wahl, M.C. | 登録日 | 2022-10-15 | 公開日 | 2023-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2. Acta Crystallogr D Struct Biol, 79, 2023
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8BCH
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8BC9
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 24 | 分子名称: | 1,2-ETHANEDIOL, N-hydroxybenzenesulfonamide, Pre-mRNA-processing-splicing factor 8, ... | 著者 | Vester, K, Loll, B, Wahl, M.C. | 登録日 | 2022-10-15 | 公開日 | 2023-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2. Acta Crystallogr D Struct Biol, 79, 2023
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8BC8
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 18 | 分子名称: | 1,2-ETHANEDIOL, 3-azanyl-4-oxidanyl-benzenesulfonamide, Pre-mRNA-processing-splicing factor 8, ... | 著者 | Vester, K, Loll, B, Wahl, M.C. | 登録日 | 2022-10-15 | 公開日 | 2023-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2. Acta Crystallogr D Struct Biol, 79, 2023
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8BCD
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8BCE
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 76 | 分子名称: | 1,2-ETHANEDIOL, N-methoxybenzenesulfonamide, Pre-mRNA-processing-splicing factor 8, ... | 著者 | Vester, K, Loll, B, Wahl, M.C. | 登録日 | 2022-10-15 | 公開日 | 2023-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2. Acta Crystallogr D Struct Biol, 79, 2023
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8BCA
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 26 | 分子名称: | 1,2-ETHANEDIOL, 3-azanyl-~{N}-methyl-4-(methylamino)benzenesulfonamide, GLYCEROL, ... | 著者 | Vester, K, Loll, B, Wahl, M.C. | 登録日 | 2022-10-15 | 公開日 | 2023-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2. Acta Crystallogr D Struct Biol, 79, 2023
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8BCF
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 78 | 分子名称: | 1,2-ETHANEDIOL, Pre-mRNA-processing-splicing factor 8, U5 small nuclear ribonucleoprotein 200 kDa helicase, ... | 著者 | Vester, K, Loll, B, Wahl, M.C. | 登録日 | 2022-10-15 | 公開日 | 2023-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2. Acta Crystallogr D Struct Biol, 79, 2023
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8BCB
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 34 | 分子名称: | 1,2-ETHANEDIOL, Pre-mRNA-processing-splicing factor 8, SULFANILAMIDE, ... | 著者 | Vester, K, Loll, B, Wahl, M.C. | 登録日 | 2022-10-15 | 公開日 | 2023-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2. Acta Crystallogr D Struct Biol, 79, 2023
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7PJH
| Crystal structure of the human spliceosomal maturation factor AAR2 bound to the RNAse H domain of PRPF8 | 分子名称: | Pre-mRNA-processing-splicing factor 8, Protein AAR2 homolog | 著者 | Preussner, M, Santos, K, Heroven, A.C, Alles, J, Heyd, F, Wahl, M.C, Weber, G. | 登録日 | 2021-08-24 | 公開日 | 2022-11-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural and functional investigation of the human snRNP assembly factor AAR2 in complex with the RNase H-like domain of PRPF8. Acta Crystallogr D Struct Biol, 78, 2022
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6S8O
| Human Brr2 Helicase Region M641C/A1582C | 分子名称: | U5 small nuclear ribonucleoprotein 200 kDa helicase | 著者 | Vester, K, Santos, K.F, Wahl, M.C. | 登録日 | 2019-07-10 | 公開日 | 2020-01-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.172 Å) | 主引用文献 | The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit. J.Biol.Chem., 295, 2020
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5K8Y
| Structure of the Mus musclus Langerin carbohydrate recognition domain | 分子名称: | C-type lectin domain family 4 member K, CALCIUM ION, GLYCEROL, ... | 著者 | Loll, B, Aretz, J, Rademacher, C, Wahl, M.C. | 登録日 | 2016-05-31 | 公開日 | 2016-12-07 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent. J. Biol. Chem., 292, 2017
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6TEO
| Crystal structure of a yeast Snu114-Prp8 complex | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Pre-mRNA-splicing factor 8, ... | 著者 | Ganichkin, O, Jia, J, Loll, B, Absmeier, E, Wahl, M.C. | 登録日 | 2019-11-12 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | A Snu114-GTP-Prp8 module forms a relay station for efficient splicing in yeast. Nucleic Acids Res., 48, 2020
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6TQN
| rrn anti-termination complex without S4 | 分子名称: | 30S ribosomal protein S10, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Huang, Y.H, Wahl, M.C, Loll, B, Hilal, T, Said, N. | 登録日 | 2019-12-17 | 公開日 | 2020-08-05 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis. Mol.Cell, 79, 2020
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6TQO
| rrn anti-termination complex | 分子名称: | 30S ribosomal protein S10, 30S ribosomal protein S4, DNA-directed RNA polymerase subunit alpha, ... | 著者 | Huang, Y.H, Wahl, M.C, Loll, B, Hilal, T, Said, N. | 登録日 | 2019-12-17 | 公開日 | 2020-08-05 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis. Mol.Cell, 79, 2020
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6TW2
| Re-refined crystal structure of di-phosphorylated human CLK1 in complex with a novel substituted indole inhibitor | 分子名称: | Dual specificity protein kinase CLK1, ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate | 著者 | Loll, B, Haltenhof, T, Heyd, F, Wahl, M.C. | 登録日 | 2020-01-12 | 公開日 | 2020-02-05 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A Conserved Kinase-Based Body-Temperature Sensor Globally Controls Alternative Splicing and Gene Expression. Mol.Cell, 78, 2020
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5LWO
| Structure of Spin-labelled T4 lysozyme mutant L115C-R119C-R1 at 100K | 分子名称: | 2-HYDROXYETHYL DISULFIDE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | 著者 | Loll, B, Consentius, P, Gohlke, U, Mueller, R, Kaupp, M, Heinemann, U, Wahl, M.C, Risse, T. | 登録日 | 2016-09-18 | 公開日 | 2017-03-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.183 Å) | 主引用文献 | Internal Dynamics of the 3-Pyrroline-N-Oxide Ring in Spin-Labeled Proteins. J Phys Chem Lett, 8, 2017
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