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6Z0E
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BU of 6z0e by Molmil
HtrA1 inactive protease domain S328A with CARASIL mutation R274Q
Descriptor: CALCIUM ION, Serine protease HTRA1
Authors:Vetter, I.R, Stege, P, Ingendahl, L, Ehrmann, M.
Deposit date:2020-05-08
Release date:2021-05-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Repair strategies addressing pathogenic protein conformations
To Be Published
6Z0Y
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BU of 6z0y by Molmil
HtrA1 inactive protease domain S328A with CARASIL mutations D174R R274Q
Descriptor: SULFATE ION, Serine protease HTRA1
Authors:Vetter, I.R, Stege, P, Ingendahl, L, Ehrmann, M.
Deposit date:2020-05-11
Release date:2021-05-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Repair strategies addressing pathogenic protein conformations
To Be Published
6Z0X
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BU of 6z0x by Molmil
HtrA1 inactive protease domain S328A with CARASIL mutations D174R R274Q
Descriptor: SULFATE ION, Serine protease HTRA1
Authors:Vetter, I.R, Stege, P, Ingendahl, L, Ehrmann, M.
Deposit date:2020-05-11
Release date:2021-05-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Repair strategies addressing pathogenic protein conformations
To Be Published
6ZRD
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BU of 6zrd by Molmil
STRUCTURE OF THE HUMAN RBAP48 in complex with a macrocyclic peptide cyclized via a xylene linker attached to two cysteines
Descriptor: 1,3,5-trimethylbenzene, Histone-binding protein RBBP4, macrocyclic peptide based on residues 659-672 of the metastasis-associated protein MTA1
Authors:Vetter, I.R, Porfetye, A.T.
Deposit date:2020-07-13
Release date:2020-12-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48.
Angew.Chem.Int.Ed.Engl., 60, 2021
6ZRC
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BU of 6zrc by Molmil
Structure of the human RBAP48 in complex with a macrocyclic peptide cyclized via a xylene linker attached to two cysteines
Descriptor: Histone-binding protein RBBP4, PARA-XYLENE, macrocyclic peptide based on residues 659-672 of the metastasis-associated protein MTA1
Authors:Vetter, I.R, Porfetye, A.T.
Deposit date:2020-07-13
Release date:2020-10-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48.
Angew.Chem.Int.Ed.Engl., 60, 2021
1V9D
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BU of 1v9d by Molmil
Crystal structure of the core FH2 domain of mouse mDia1
Descriptor: Diaphanous protein homolog 1, SULFATE ION
Authors:Shimada, A, Nyitrai, M, Vetter, I.R, Kuhlmann, D, Bugyi, B, Narumiya, S, Geeves, M.A, Wittinghofer, A.
Deposit date:2004-01-24
Release date:2004-03-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization.
Mol.Cell, 13, 2004
6GY7
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BU of 6gy7 by Molmil
Crystal structure of XaxB from Xenorhabdus nematophil
Descriptor: XaxB
Authors:Schubert, E, Raunser, S, Vetter, I.R, Prumbaum, D, Penczek, P.A.
Deposit date:2018-06-28
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Membrane insertion of alpha-xenorhabdolysin in near-atomic detail.
Elife, 7, 2018
3U0V
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BU of 3u0v by Molmil
Crystal Structure Analysis of human LYPLAL1
Descriptor: Lysophospholipase-like protein 1
Authors:Burger, M, Zimmermann, T.J, Kondoh, Y, Stege, P, Watanabe, N, Osada, H, Waldmann, H, Vetter, I.R.
Deposit date:2011-09-29
Release date:2011-11-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases
J.Lipid Res., 53, 2012
1K5D
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BU of 1k5d by Molmil
Crystal structure of Ran-GPPNHP-RanBP1-RanGAP complex
Descriptor: GTP-binding nuclear protein RAN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Seewald, M.J, Koerner, C, Wittinghofer, A, Vetter, I.R.
Deposit date:2001-10-10
Release date:2002-02-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:RanGAP mediates GTP hydrolysis without an arginine finger.
Nature, 415, 2002
1K5G
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BU of 1k5g by Molmil
Crystal structure of Ran-GDP-AlFx-RanBP1-RanGAP complex
Descriptor: ALUMINUM FLUORIDE, GTP-binding nuclear protein RAN, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Seewald, M.J, Koerner, C, Wittinghofer, A, Vetter, I.R.
Deposit date:2001-10-10
Release date:2002-02-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:RanGAP mediates GTP hydrolysis without an arginine finger.
Nature, 415, 2002
8P0S
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BU of 8p0s by Molmil
Crystal structure HR1 domain of Rho-associated coiled-coil protein kinases (ROCK-HR1)
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Rho-associated protein kinase 1
Authors:Dubey, B.N, Dvorsky, R, Gremer, L, Vetter, I.R, Schmitt, L, Groth, G, Ahmadian, M.R.
Deposit date:2023-05-10
Release date:2023-06-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and functional insights into the p160 Rho-associated coiled-coil-containing protein kinase
To Be Published
7QPG
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BU of 7qpg by Molmil
Human RZZ kinetochore corona complex.
Descriptor: Centromere/kinetochore protein zw10 homolog, Kinetochore-associated protein 1, Protein zwilch homolog
Authors:Raisch, T, Ciossani, G, d'Amico, E, Cmetowski, V, Carmignani, S, Maffini, S, Merino, F, Wohlgemuth, S, Vetter, I.R, Raunser, S, Musacchio, A.
Deposit date:2022-01-04
Release date:2022-03-16
Last modified:2022-05-11
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the RZZ complex and molecular basis of Spindly-driven corona assembly at human kinetochores.
Embo J., 41, 2022
3T1O
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BU of 3t1o by Molmil
MglA bound to GDP
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GUANOSINE-5'-DIPHOSPHATE, Gliding protein mglA, ...
Authors:Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A.
Deposit date:2011-07-22
Release date:2011-08-31
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
6GN5
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BU of 6gn5 by Molmil
CRYSTAL STRUCTURE OF HUMAN GRAMD1C START DOMAIN
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GRAM domain-containing protein 1C
Authors:Friese, A, Vetter, I.R.
Deposit date:2018-05-30
Release date:2019-06-19
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis.
Nat.Chem.Biol., 15, 2019
3T1V
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BU of 3t1v by Molmil
MglA bound to GDP in P2(1) tetrameric arrangement
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Gliding protein mglA
Authors:Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A.
Deposit date:2011-07-22
Release date:2011-08-31
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
3T12
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BU of 3t12 by Molmil
MglA in complex with MglB in transition state
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Gliding protein MglB, Gliding protein mglA, ...
Authors:Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A.
Deposit date:2011-07-21
Release date:2011-08-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
5IH4
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BU of 5ih4 by Molmil
Human Casein Kinase 1 isoform delta apo (kinase domain)
Descriptor: Casein kinase I isoform delta, S,R MESO-TARTARIC ACID, SULFATE ION, ...
Authors:Ursu, A, Illich, D.J, Takemoto, Y, Porfetye, A.T, Zhang, M, Brockmeyer, A, Janning, P, Watanabe, N, Osada, H, Vetter, I.R, Ziegler, S, Schoeler, H.R, Waldmann, H.
Deposit date:2016-02-29
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1.
Cell Chem Biol, 23, 2016
5IH6
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BU of 5ih6 by Molmil
Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A derivative
Descriptor: 6-(3-bromophenyl)pteridine-2,4,7-triamine, Casein kinase I isoform delta, S,R MESO-TARTARIC ACID, ...
Authors:Ursu, A, Illich, D.J, Takemoto, Y, Porfetye, A.T, Zhang, M, Brockmeyer, A, Janning, P, Watanabe, N, Osada, H, Vetter, I.R, Ziegler, S, Schoeler, H.R, Waldmann, H.
Deposit date:2016-02-29
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1.
Cell Chem Biol, 23, 2016
5IH5
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BU of 5ih5 by Molmil
Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A
Descriptor: 6-(3-chlorophenyl)pteridine-2,4,7-triamine, Casein kinase I isoform delta, S,R MESO-TARTARIC ACID, ...
Authors:Ursu, A, Illich, D.J, Takemoto, Y, Porfetye, A.T, Zhang, M, Brockmeyer, A, Janning, P, Watanabe, N, Osada, H, Vetter, I.R, Ziegler, S, Schoeler, H.R, Waldmann, H.
Deposit date:2016-02-29
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1.
Cell Chem Biol, 23, 2016
2RFO
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BU of 2rfo by Molmil
Crystral Structure of the nucleoporin Nic96
Descriptor: Nucleoporin NIC96
Authors:Schrader, N, Stelter, P, Flemming, D, Kunze, K, Hurt, E, Vetter, I.R.
Deposit date:2007-10-01
Release date:2008-01-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of the nic96 subcomplex organization in the nuclear pore channel.
Mol.Cell, 29, 2008
4I1M
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BU of 4i1m by Molmil
Crystal structure of the Legionella pneumophila GAP domain of LepB
Descriptor: DI(HYDROXYETHYL)ETHER, LepB
Authors:Streller, A, Gazdag, E.M, Vetter, I.R, Goody, R.S, Itzen, A.
Deposit date:2012-11-21
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.804 Å)
Cite:Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB.
Embo Rep., 14, 2013
1XZP
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BU of 1xzp by Molmil
Structure of the GTP-binding protein TrmE from Thermotoga maritima
Descriptor: Probable tRNA modification GTPase trmE, SULFATE ION
Authors:Scrima, A, Vetter, I.R, Armengod, M.E, Wittinghofer, A.
Deposit date:2004-11-12
Release date:2005-01-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of the TrmE GTP-binding protein and its implications for tRNA modification
Embo J., 24, 2005
1XZQ
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BU of 1xzq by Molmil
Structure of the GTP-binding protein TrmE from Thermotoga maritima complexed with 5-formyl-THF
Descriptor: N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, Probable tRNA modification GTPase trmE
Authors:Scrima, A, Vetter, I.R, Armengod, M.E, Wittinghofer, A.
Deposit date:2004-11-12
Release date:2005-01-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The structure of the TrmE GTP-binding protein and its implications for tRNA modification
Embo J., 24, 2005
1YRG
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BU of 1yrg by Molmil
THE CRYSTAL STRUCTURE OF RNA1P: A NEW FOLD FOR A GTPASE-ACTIVATING PROTEIN
Descriptor: GTPASE-ACTIVATING PROTEIN RNA1_SCHPO
Authors:Hillig, R.C, Renault, L, Vetter, I.R, Drell, T, Wittinghofer, A, Becker, J.
Deposit date:1999-03-29
Release date:2000-03-29
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:The crystal structure of rna1p: a new fold for a GTPase-activating protein.
Mol.Cell, 3, 1999
6C0W
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BU of 6c0w by Molmil
Cryo-EM structure of human kinetochore protein CENP-N with the centromeric nucleosome containing CENP-A
Descriptor: 147 mer DNA, Centromere protein N, Histone H2A, ...
Authors:Zhou, K, Pentakota, S, Vetter, I.R, Morgan, G.P, Petrovic, A, Musacchio, A, Luger, K.
Deposit date:2018-01-02
Release date:2018-01-17
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Decoding the centromeric nucleosome through CENP-N.
Elife, 6, 2017

219515

数据于2024-05-08公开中

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