5VR3
 
 | | Crystal structure of the BRS domain of BRAF | | 分子名称: | BRAF, SULFATE ION | | 著者 | Thevakumaran, N, Maisonneuve, P, Kurinov, I, Lavoie, H, Marullo, S.A, Sahmi, M, Jin, T, Therrien, M, Sicheri, F. | | 登録日 | 2017-05-10 | | 公開日 | 2018-02-14 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | | 主引用文献 | MEK drives BRAF activation through allosteric control of KSR proteins.
Nature, 554, 2018
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5VYK
 | | Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1 | | 分子名称: | Chimera protein of BRS domain of BRAF and CC-SAM domain of KSR1,Serine/threonine-protein kinase B-raf, GLYCEROL | | 著者 | Maisonneuve, P, Kurinov, I, Marullo, S.A, Lavoie, H, Thevakumaran, N, Sahmi, M, Jin, T, Therrien, M, SIcheri, F. | | 登録日 | 2017-05-25 | | 公開日 | 2018-02-14 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.749 Å) | | 主引用文献 | MEK drives BRAF activation through allosteric control of KSR proteins.
Nature, 554, 2018
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4JVG
 | | B-Raf Kinase in Complex with Birb796 | | 分子名称: | 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA, Serine/threonine-protein kinase B-raf | | 著者 | Lavoie, H, Thevakumaran, N, Gavory, G, Li, J, Padeganeh, A, Guiral, S, Duchaine, J, Mao, D.Y.L, Bouvier, M, Sicheri, F, Therrien, M. | | 登録日 | 2013-03-25 | | 公開日 | 2013-05-29 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | | 主引用文献 | Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.
Nat.Chem.Biol., 9, 2013
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4PL3
 | | Crystal structure of murine IRE1 in complex with MKC9989 inhibitor | | 分子名称: | 7-hydroxy-6-methoxy-3-[2-(2-methoxyethoxy)ethyl]-4,8-dimethyl-2H-chromen-2-one, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Sanches, M, Duffy, N, Talukdar, M, Thevakumaran, N, Chiovitti, D, Al-awar, R, Patterson, J.B, Sicheri, F. | | 登録日 | 2014-05-16 | | 公開日 | 2014-09-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Nat Commun, 5, 2014
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4PL4
 | | Crystal structure of murine IRE1 in complex with OICR464 inhibitor | | 分子名称: | 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, 2-methoxy-6-methyl-4-(4-methyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)phenol, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Sanches, M, Duffy, N, Talukdar, M, Thevakumaran, N, Chiovitti, D, Al-awar, R, Patterson, J.B, Sicheri, F. | | 登録日 | 2014-05-16 | | 公開日 | 2014-09-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Nat Commun, 5, 2014
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4PL5
 | | Crystal structure of murine IRE1 in complex with OICR573 inhibitor | | 分子名称: | 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, 3-methoxy-5-methyl-4'-(morpholin-4-yl)biphenyl-4-ol, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Sanches, M, Duffy, N, Talukdar, M, Thevakumaran, N, Chiovitti, D, Al-awar, R, Patterson, J.B, Sicheri, F. | | 登録日 | 2014-05-16 | | 公開日 | 2014-09-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Nat Commun, 5, 2014
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4WO5
 | | Crystal structure of a BRAF kinase domain monomer | | 分子名称: | N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide, Serine/threonine-protein kinase B-raf | | 著者 | Critton, D.A. | | 登録日 | 2014-10-15 | | 公開日 | 2014-12-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.
Nat.Struct.Mol.Biol., 22, 2015
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4O1O
 | | Crystal Structure of RNase L in complex with 2-5A | | 分子名称: | Ribonuclease L, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate | | 著者 | Huang, H, Zeqiraj, E, Ceccarelli, D.F, Sicheri, F. | | 登録日 | 2013-12-16 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.27 Å) | | 主引用文献 | Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Mol.Cell, 53, 2014
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4O1P
 | | Crystal Structure of RNase L in complex with 2-5A and AMP-PNP | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribonuclease L, ... | | 著者 | Huang, H, Zeqiraj, E, Ceccarelli, D.F, Sicheri, F. | | 登録日 | 2013-12-16 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Mol.Cell, 53, 2014
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5JMV
 | | Crystal structure of mjKae1-pfuPcc1 complex | | 分子名称: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein, ... | | 著者 | Wan, L, Sicheri, F. | | 登録日 | 2016-04-29 | | 公開日 | 2016-07-06 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.3864696 Å) | | 主引用文献 | Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis.
Nucleic Acids Res., 44, 2016
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4K25
 | | Crystal Structure of yeast Qri7 homodimer | | 分子名称: | CALCIUM ION, Probable tRNA threonylcarbamoyladenosine biosynthesis protein QRI7, mitochondrial, ... | | 著者 | Neculai, D, Wan, L, Mao, D.Y, Sicheri, F. | | 登録日 | 2013-04-08 | | 公開日 | 2013-05-08 | | 最終更新日 | 2013-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | | 主引用文献 | Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.
Nucleic Acids Res., 41, 2013
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