8HTR
| Crystal structure of Bcl2 in complex with S-9c | 分子名称: | 4-[4-[(2~{S})-2-(2-chlorophenyl)pyrrolidin-1-yl]phenyl]-~{N}-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide, Apoptosis regulator Bcl-2 | 著者 | Liu, J, Xu, M, Feng, Y, Liu, Y. | 登録日 | 2022-12-21 | 公開日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2. J.Med.Chem., 2024
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8HTS
| Crystal structure of Bcl2 in complex with S-10r | 分子名称: | 4-[2-[(2~{S})-2-(2-cyclopropylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-~{N}-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide, Apoptosis regulator Bcl-2 | 著者 | Liu, J, Xu, M, Feng, Y, Liu, Y. | 登録日 | 2022-12-21 | 公開日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2. J.Med.Chem., 2024
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6UIW
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6UIV
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6UIX
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6CUD
| Structure of the human TRPC3 in a lipid-occupied, closed state | 分子名称: | (2R)-3-hydroxypropane-1,2-diyl dihexanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lu, W, Du, J, Fan, C, Choi, W. | 登録日 | 2018-03-25 | 公開日 | 2018-05-16 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of the human lipid-gated cation channel TRPC3. Elife, 7, 2018
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3UDC
| Crystal structure of a membrane protein | 分子名称: | Small-conductance mechanosensitive channel, C-terminal peptide from Small-conductance mechanosensitive channel | 著者 | Li, W, Ge, J, Yang, M. | 登録日 | 2011-10-28 | 公開日 | 2012-10-31 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.355 Å) | 主引用文献 | Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance Proc.Natl.Acad.Sci.USA, 109, 2012
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7U8J
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7U8L
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7U8M
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1HZU
| DOMAIN SWING UPON HIS TO ALA MUTATION IN NITRITE REDUCTASE OF PSEUDOMONAS AERUGINOSA | 分子名称: | HEME C, HEME D, NITRITE REDUCTASE | 著者 | Brown, K, Cutruzzola, F, Brunori, M, Tegoni, M, Cambillau, C. | 登録日 | 2001-01-26 | 公開日 | 2001-09-26 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Domain swing upon His to Ala mutation in nitrite reductase of Pseudomonas aeruginosa. J.Mol.Biol., 312, 2001
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1HZV
| DOMAIN SWING UPON HIS TO ALA MUTATION IN NITRITE REDUCTASE OF PSEUDOMONAS AERUGINOSA | 分子名称: | HEME C, HEME D, NITRIC OXIDE, ... | 著者 | Brown, K, Tegoni, M, Cambillau, C. | 登録日 | 2001-01-26 | 公開日 | 2001-09-26 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Domain swing upon His to Ala mutation in nitrite reductase of Pseudomonas aeruginosa. J.Mol.Biol., 312, 2001
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6R48
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6R46
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7C7P
| Crystal structure of the SARS-CoV-2 main protease in complex with Telaprevir | 分子名称: | (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide, 3C-like proteinase, CHLORIDE ION | 著者 | Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Yang, S.Y, Lei, J. | 登録日 | 2020-05-26 | 公開日 | 2020-07-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model. Science, 371, 2021
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7COM
| Crystal structure of the SARS-CoV-2 main protease in complex with Boceprevir (space group P212121) | 分子名称: | 3C-like proteinase, boceprevir (bound form) | 著者 | Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Liu, J.M, Zhou, Y.L, Chen, P, Yang, S.Y, Lei, J. | 登録日 | 2020-08-04 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model. Science, 371, 2021
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6RNW
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6RNV
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6IE2
| Crystal structure of methyladenine demethylase | 分子名称: | 2-OXOGLUTARIC ACID, MANGANESE (II) ION, Nucleic acid dioxygenase ALKBH1 | 著者 | Tian, L.F, Tang, Q, Chen, Z.Z, Yan, X.X. | 登録日 | 2018-09-13 | 公開日 | 2019-09-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1. Cell Res., 30, 2020
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6IE3
| Crystal structure of methyladenine demethylase | 分子名称: | ETHANOL, MANGANESE (II) ION, Nucleic acid dioxygenase ALKBH1 | 著者 | Tian, L.F, Tang, Q, Chen, Z.Z, Yan, X.X. | 登録日 | 2018-09-13 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1. Cell Res., 30, 2020
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3T9N
| Crystal structure of a membrane protein | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Small-conductance mechanosensitive channel | 著者 | Yang, M, Zhang, X, Ge, J, Wang, J. | 登録日 | 2011-08-03 | 公開日 | 2012-10-31 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.456 Å) | 主引用文献 | Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance Proc.Natl.Acad.Sci.USA, 109, 2012
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7BYR
| BD23-Fab in complex with the S ectodomain trimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab23-Fab-Heavy Chain, ... | 著者 | Zhu, Q, Wang, G, Xiao, J. | 登録日 | 2020-04-24 | 公開日 | 2020-06-10 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | 主引用文献 | Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells. Cell, 182, 2020
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8EQF
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7SVL
| DPP9 IN COMPLEX WITH LIGAND ICeD-2 | 分子名称: | (2S)-2-amino-1-(1,3-dihydro-2H-isoindol-2-yl)-2-[(1r,4S)-4-(pyrrolidin-1-yl)cyclohexyl]ethan-1-one, Dipeptidyl peptidase 9 | 著者 | Lammens, A, Hollenstein, K, Klein, D.J. | 登録日 | 2021-11-19 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells. Acs Chem.Biol., 17, 2022
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7SVM
| DPP8 IN COMPLEX WITH LIGAND ICeD-2 | 分子名称: | (2S)-2-amino-1-(1,3-dihydro-2H-isoindol-2-yl)-2-[(1r,4S)-4-(pyrrolidin-1-yl)cyclohexyl]ethan-1-one, Dipeptidyl peptidase 8, trimethylamine oxide | 著者 | Lammens, A, Hollenstein, K, Klein, D.J. | 登録日 | 2021-11-19 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells. Acs Chem.Biol., 17, 2022
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