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5E9O
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BU of 5e9o by Molmil
Spirochaeta thermophila X module - CBM64 - mutant G504A
Descriptor: 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, Cellulase, glycosyl hydrolase family 5, ...
Authors:Schiefner, A, Skerra, A.
Deposit date:2015-10-15
Release date:2016-03-02
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for cellulose binding by the type A carbohydrate-binding module 64 of Spirochaeta thermophila.
Proteins, 84, 2016
5E9P
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BU of 5e9p by Molmil
Spirochaeta thermophila X module - CBM64 - wildtype
Descriptor: Cellulase, glycosyl hydrolase family 5, TPS linker, ...
Authors:Schiefner, A, Skerra, A.
Deposit date:2015-10-15
Release date:2016-03-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural basis for cellulose binding by the type A carbohydrate-binding module 64 of Spirochaeta thermophila.
Proteins, 84, 2016
7P85
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BU of 7p85 by Molmil
Engineered phosphotriesterase BdPTE 10-2-C3(C59V/C227V) in complex with ethyl-4-methylbenzylphosphonate
Descriptor: FORMIC ACID, GLYCEROL, Parathion hydrolase, ...
Authors:Eichinger, A, Skerra, A.
Deposit date:2021-07-21
Release date:2022-08-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structural and Functional Analysis of a Highly Active Designed Phosphotriesterase for the Detoxification of Organophosphate Nerve Agents Reveals an Unpredicted Conformation of the Active Site Loop.
Biochemistry, 62, 2023
3DDY
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BU of 3ddy by Molmil
Structure of lumazine protein, an optical transponder of luminescent bacteria
Descriptor: Lumazine protein, RIBOFLAVIN
Authors:Chatwell, L, Illarionova, V, Illarionov, B, Skerra, A, Bacher, A, Fischer, M.
Deposit date:2008-06-07
Release date:2008-07-01
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of lumazine protein, an optical transponder of luminescent bacteria.
J.Mol.Biol., 382, 2008
1GPO
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BU of 1gpo by Molmil
CRYSTAL STRUCTURE OF THE RATIONALLY DESIGNED ANTIBODY M41 AS A FAB FRAGMENT
Descriptor: ANTIBODY M41, SULFATE ION
Authors:Schiweck, W, Skerra, A.
Deposit date:1997-03-27
Release date:1998-04-01
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The rational construction of an antibody against cystatin: lessons from the crystal structure of an artificial Fab fragment.
J.Mol.Biol., 268, 1997
1SG2
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BU of 1sg2 by Molmil
Crystal structure of the periplasmic chaperone Skp
Descriptor: Seventeen Kilodalton Protein
Authors:Korndorfer, I.P, Dommel, M.K, Skerra, A.
Deposit date:2004-02-23
Release date:2004-09-14
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of the periplasmic chaperone Skp suggests functional similarity with cytosolic chaperones despite differing architecture.
Nat.Struct.Mol.Biol., 11, 2004
2HZQ
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BU of 2hzq by Molmil
Crystal structure of human apolipoprotein D (ApoD) in complex with progesterone
Descriptor: Apolipoprotein D, PROGESTERONE
Authors:Eichinger, A, Skerra, A.
Deposit date:2006-08-09
Release date:2007-08-14
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insight into the dual ligand specificity and mode of high density lipoprotein association of apolipoprotein d.
J.Biol.Chem., 282, 2007
2HZR
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BU of 2hzr by Molmil
Crystal structure of human apolipoprotein D (ApoD)
Descriptor: Apolipoprotein D
Authors:Eichinger, A, Skerra, A.
Deposit date:2006-08-09
Release date:2007-08-14
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insight into the dual ligand specificity and mode of high density lipoprotein association of apolipoprotein d.
J.Biol.Chem., 282, 2007
3DSZ
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BU of 3dsz by Molmil
Engineered human lipocalin 2 in complex with Y-DTPA
Descriptor: N-{(1S,2S)-2-[bis(carboxymethyl)amino]cyclohexyl}-N-{(2R)-2-[bis(carboxymethyl)amino]-3-[4-({[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]carbamothioyl}amino)phenyl]propyl}glycine, YTTRIUM (III) ION, engineered human lipocalin 2
Authors:Eichinger, A, Skerra, A.
Deposit date:2008-07-14
Release date:2009-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-affinity recognition of lanthanide(III) chelate complexes by a reprogrammed human lipocalin 2
J.Am.Chem.Soc., 131, 2009
3DTQ
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BU of 3dtq by Molmil
Engineered human lipocalin 2 with specificity for Y-DTPA, apo-form
Descriptor: Neutrophil gelatinase-associated lipocalin
Authors:Eichinger, A, Skerra, A.
Deposit date:2008-07-15
Release date:2009-05-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:High-affinity recognition of lanthanide(III) chelate complexes by a reprogrammed human lipocalin 2.
J.Am.Chem.Soc., 131, 2009
3T1W
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BU of 3t1w by Molmil
Structure of the four-domain fragment Fn7B89 of oncofetal fibronectin
Descriptor: four-domain fibronectin fragment
Authors:Schiefner, A, Skerra, A.
Deposit date:2011-07-22
Release date:2012-03-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Extra-domain B in oncofetal fibronectin structurally promotes fibrillar head-to-tail dimerization of extracellular matrix protein.
J.Biol.Chem., 287, 2012
7O31
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BU of 7o31 by Molmil
Crystal structure of the anti-PAS Fab 1.2 in complex with its epitope peptide and the anti-Kappa VHH domain
Descriptor: 1,2-ETHANEDIOL, PAS#1 epitope peptide, anti-Kappa VHH domain, ...
Authors:Schilz, J, Schiefner, A, Skerra, A.
Deposit date:2021-04-01
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Molecular recognition of structurally disordered Pro/Ala-rich sequences (PAS) by antibodies involves an Ala residue at the hot spot of the epitope.
J.Mol.Biol., 433, 2021
7O30
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BU of 7o30 by Molmil
Crystal structure of the anti-PAS Fab 1.1 in complex with its epitope peptide
Descriptor: PAS#1 epitope peptide, anti-PAS Fab 1.1 chimeric heavy chain, anti-PAS Fab 1.1 chimeric light chain
Authors:Schilz, J, Schiefner, A, Skerra, A.
Deposit date:2021-04-01
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Molecular recognition of structurally disordered Pro/Ala-rich sequences (PAS) by antibodies involves an Ala residue at the hot spot of the epitope.
J.Mol.Biol., 433, 2021
7O2Z
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BU of 7o2z by Molmil
Crystal structure of the anti-PAS Fab 2.2 in complex with its epitope peptide
Descriptor: CHLORIDE ION, P/A#1 epitope peptide, anti-PAS Fab 2.2 chimeric heavy chain, ...
Authors:Schilz, J, Schiefner, A, Skerra, A.
Deposit date:2021-04-01
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Molecular recognition of structurally disordered Pro/Ala-rich sequences (PAS) by antibodies involves an Ala residue at the hot spot of the epitope.
J.Mol.Biol., 433, 2021
3BX7
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BU of 3bx7 by Molmil
Engineered Human Lipocalin 2 (LCN2) in Complex with the Extracellular Domain of Human CTLA-4
Descriptor: CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 4, ENGINEERED HUMAN LIPOCALIN 2
Authors:Schonfeld, D.L, Chatwell, L, Skerra, A.
Deposit date:2008-01-11
Release date:2009-01-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High affinity molecular recognition and functional blockade of CTLA-4 by an engineered human lipocalin
To be Published
3BX8
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BU of 3bx8 by Molmil
Engineered Human Lipocalin 2 (LCN2), apo-form
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ENGINEERED HUMAN LIPOCALIN 2, PENTAETHYLENE GLYCOL
Authors:Schonfeld, D.L, Chatwell, L, Skerra, A.
Deposit date:2008-01-11
Release date:2009-01-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:High affinity molecular recognition and functional blockade of CTLA-4 by an engineered human lipocalin
To be Published
1IVL
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BU of 1ivl by Molmil
THE DE NOVO DESIGN OF AN ANTIBODY COMBINING SITE: CRYSTALLOGRAPHIC ANALYSIS OF THE VL DOMAIN CONFIRMS THE STRUCTURAL MODEL
Descriptor: IGG-KAPPA M29B FV (LIGHT CHAIN), ISOPROPYL ALCOHOL
Authors:Essen, L.-O, Skerra, A.
Deposit date:1994-05-04
Release date:1994-08-31
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:The de novo design of an antibody combining site. Crystallographic analysis of the VL domain confirms the structural model.
J.Mol.Biol., 238, 1994
7O33
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BU of 7o33 by Molmil
Crystal structure of the anti-PAS Fab 3.1 in complex with its epitope peptide
Descriptor: APSA epitope peptide, anti-PAS Fab 3.1 chimeric heavy chain, anti-PAS Fab 3.1 chimeric light chain
Authors:Schilz, J, Skerra, A.
Deposit date:2021-04-01
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular recognition of structurally disordered Pro/Ala-rich sequences (PAS) by antibodies involves an Ala residue at the hot spot of the epitope.
J.Mol.Biol., 433, 2021
1KXO
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BU of 1kxo by Molmil
ENGINEERED LIPOCALIN DIGA16 : APO-FORM
Descriptor: DigA16
Authors:Korndoerfer, I.P, Skerra, A.
Deposit date:2002-02-01
Release date:2003-06-10
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural mechanism of specific ligand recognition by a lipocalin tailored for the complexation of digoxigenin.
J.Mol.Biol., 330, 2003
1LKE
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BU of 1lke by Molmil
ENGINEERED LIPOCALIN DIGA16 IN COMPLEX WITH DIGOXIGENIN
Descriptor: DIGOXIGENIN, DigA16
Authors:Korndoerfer, I.P, Skerra, A.
Deposit date:2002-04-25
Release date:2003-06-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural mechanism of specific ligand recognition by a lipocalin tailored for the complexation of digoxigenin.
J.Mol.Biol., 330, 2003
1LNM
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BU of 1lnm by Molmil
ANTICALIN DIGA16 IN COMPLEX WITH DIGITOXIGENIN
Descriptor: DIGITOXIGENIN, DigA16
Authors:Korndoerfer, I.P, Skerra, A.
Deposit date:2002-05-03
Release date:2003-06-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural mechanism of specific ligand recognition by a lipocalin tailored for the complexation of digoxigenin.
J.Mol.Biol., 330, 2003
6S8V
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BU of 6s8v by Molmil
Structure of the high affinity Anticalin P3D11 in complex with the human CD98 heavy chain ectodomain
Descriptor: 1,2-ETHANEDIOL, 4F2 cell-surface antigen heavy chain, Neutrophil gelatinase-associated lipocalin
Authors:Schiefner, A, Deuschle, F.-C, Skerra, A.
Deposit date:2019-07-10
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Development of a high affinity Anticalin®directed against human CD98hc for theranostic applications.
Theranostics, 10, 2020
6SUA
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BU of 6sua by Molmil
Structure of the high affinity engineered lipocalin C1B12 in complex with the mouse CD98 heavy chain ectodomain
Descriptor: 4F2 cell-surface antigen heavy chain, Neutrophil gelatinase-associated lipocalin, SULFATE ION
Authors:Schiefner, A, Deuschle, F.-C, Skerra, A.
Deposit date:2019-09-13
Release date:2020-06-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Design of a surrogate Anticalin protein directed against CD98hc for preclinical studies in mice.
Protein Sci., 29, 2020
1XOV
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BU of 1xov by Molmil
The crystal structure of the listeria monocytogenes bacteriophage PSA endolysin PlyPSA
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLUTAMIC ACID, ...
Authors:Korndoerfer, I.P, Skerra, A.
Deposit date:2004-10-07
Release date:2005-10-18
Last modified:2024-01-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structure of the bacteriophage PSA endolysin reveals a unique fold responsible for specific recognition of Listeria cell walls
J.Mol.Biol., 364, 2006
4IDE
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BU of 4ide by Molmil
Structure of the Fragaria x ananassa enone oxidoreductase in complex with NADP+ and EDHMF
Descriptor: (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one, 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Schiefner, A, Skerra, A.
Deposit date:2012-12-12
Release date:2013-04-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone
J.Biol.Chem., 288, 2013

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