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5NZ5
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BU of 5nz5 by Molmil
A C145S mutant of Nesterenkonia AN1 amidase from the nitrilase superfamily
Descriptor: Amidase
Authors:Kimani, S.W, Sewell, B.T.
Deposit date:2017-05-12
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Substrate recognition by an amidase of the nitrilase superfamily
To be published
5NYC
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BU of 5nyc by Molmil
A C145A mutant of Nesterenkonia AN1 amidase bound to propionitrile
Descriptor: Amidase, DI(HYDROXYETHYL)ETHER, propanenitrile
Authors:Kimani, S.W, Sewell, B.T.
Deposit date:2017-05-11
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Substrate recognition by an amidase of the nitrilase superfamily
To be published
5NY7
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BU of 5ny7 by Molmil
A C145A mutant of Nesterenkonia AN1 amidase bound to nicotinamide
Descriptor: Amidase, CHLORIDE ION, NICOTINAMIDE
Authors:Kimani, S.W, Sewell, B.T.
Deposit date:2017-05-11
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Substrate recognition by an amidase of the nitrilase superfamily
To be published
5NXZ
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BU of 5nxz by Molmil
A C145A mutant of Nesterenkonia AN1 amidase from the nitrilase superfamily
Descriptor: Amidase
Authors:Kimani, S.W, Sewell, B.T.
Deposit date:2017-05-11
Release date:2018-05-30
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Substrate recognition by an amidase of the nitrilase superfamily
To be published
2DPP
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BU of 2dpp by Molmil
Crystal structure of thermostable Bacillus sp. RAPc8 nitrile hydratase
Descriptor: COBALT (II) ION, Nitrile hydratase alpha subunit, Nitrile hydratase beta subunit
Authors:Tsekoa, T.L, Tastan-Bishop, A.O, Cameron, R.A, Sewell, B.T, Sayed, M.F, Cowan, D.A.
Deposit date:2006-05-12
Release date:2007-05-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Crystal structure of thermostable Bacillus sp. RAPc8 nitrile hydratse
To be Published
4KZF
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BU of 4kzf by Molmil
The mechanism of the amidases: The effect of the mutation E142L in the amidase from Geobacillus pallidus
Descriptor: Aliphatic amidase, CHLORIDE ION
Authors:Weber, B.W, Sewell, B.T, Kimani, S.W, Varsani, A, Cowan, D.A, Hunter, R.
Deposit date:2013-05-29
Release date:2013-08-21
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning.
J.Biol.Chem., 288, 2013
3HGJ
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BU of 3hgj by Molmil
Old Yellow Enzyme from Thermus scotoductus SA-01 complexed with p-hydroxy-benzaldehyde
Descriptor: Chromate reductase, FLAVIN MONONUCLEOTIDE, P-HYDROXYBENZALDEHYDE
Authors:Opperman, D.J, Sewell, B.T, Litthauer, D, Isupov, M.N, Littlechild, J.A, van Heerden, E.
Deposit date:2009-05-14
Release date:2010-02-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a thermostable old yellow enzyme from Thermus scotoductus SA-01
Biochem.Biophys.Res.Commun., 393, 2010
3HHT
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BU of 3hht by Molmil
A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability
Descriptor: CHLORIDE ION, COBALT (III) ION, Nitrile hydratase alpha subunit, ...
Authors:Van Wyk, J.C, Sewell, B.T, Cowan, D.A, Sayed, M.F, Tsekoa, T.L, Tastan Bishop, A.O.
Deposit date:2009-05-17
Release date:2009-07-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:The high-resolution structure of a Cobalt containing nitrile hydratase
To be published
3HF3
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BU of 3hf3 by Molmil
Old Yellow Enzyme from Thermus scotoductus SA-01
Descriptor: Chromate reductase, FLAVIN MONONUCLEOTIDE, SULFATE ION
Authors:Opperman, D.J, Sewell, B.T, Litthauer, D, Isupov, M.N, Littlechild, J.A, van Heerden, E.
Deposit date:2009-05-11
Release date:2010-02-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of a thermostable old yellow enzyme from Thermus scotoductus SA-01
Biochem.Biophys.Res.Commun., 393, 2010
3L3N
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BU of 3l3n by Molmil
Testis ACE co-crystal structure with novel inhibitor lisW
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, CHLORIDE ION, ...
Authors:Watermeyer, J.M, Kroger, W.L, O'Neil, H.G, Sewell, B.T, Sturrock, E.D.
Deposit date:2009-12-17
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril.
Biochem.J., 428, 2010
6T1T
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BU of 6t1t by Molmil
Cytochrome P450 reductase in complex with NADPH from Candida tropicalis
Descriptor: FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Opperman, D.J, Sewell, B.T.
Deposit date:2019-10-06
Release date:2020-01-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Biochemical and structural insights into the cytochrome P450 reductase from Candida tropicalis.
Sci Rep, 9, 2019
4GYN
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BU of 4gyn by Molmil
The E142L mutant of the amidase from Geobacillus pallidus
Descriptor: Aliphatic amidase, CHLORIDE ION
Authors:Weber, B.W, Sewell, B.T, Kimani, S.W, Varsani, A, Cowan, D.A, Hunter, R.
Deposit date:2012-09-05
Release date:2013-08-21
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning.
J.Biol.Chem., 288, 2013
4GYL
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BU of 4gyl by Molmil
The E142L mutant of the amidase from Geobacillus pallidus showing the result of Michael addition of acrylamide at the active site cysteine
Descriptor: Aliphatic amidase, CHLORIDE ION, PROPIONAMIDE
Authors:Weber, B.W, Sewell, B.T, Kimani, S.W, Varsani, A, Cowan, D.A, Hunter, R.
Deposit date:2012-09-05
Release date:2013-08-21
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning.
J.Biol.Chem., 288, 2013
4IZT
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BU of 4izt by Molmil
The E41Q mutant of the amidase from Nesterenkonia sp. AN1 showing covalent addition of the acetamide moiety of fluoroacetamide at the active site cysteine
Descriptor: 2-fluoroacetamide, ACETAMIDE, Amidase
Authors:Kimani, S.W, Sewell, B.T.
Deposit date:2013-01-30
Release date:2014-02-12
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Covalent modifications of the active site cysteine occur as a result of mutating the glutamate of the catalytic triad in the amidase from Nesterenkonia sp.
To be Published
4IZU
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BU of 4izu by Molmil
The E41Q mutant of the amidase from Nesterenkonia sp. AN1 showing the result of Michael addition of acrylamide at the active site cysteine
Descriptor: Amidase, PROPIONAMIDE, prop-2-enamide
Authors:Kimani, S.W, Sewell, B.T.
Deposit date:2013-01-30
Release date:2014-02-12
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Covalent modifications of the active site cysteine occur as a result of mutating the glutamate of the catalytic triad in the amidase from Nesterenkonia sp.
To be Published
4IZV
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BU of 4izv by Molmil
The E41Q/C145A double mutant of the amidase from Nesterenkonia sp. AN1 in complex with acrylamide
Descriptor: Amidase, PROPIONAMIDE, prop-2-enamide
Authors:Kimani, S.W, Sewell, B.T.
Deposit date:2013-01-30
Release date:2014-02-12
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Covalent modifications of the active site cysteine occur as a result of mutating the glutamate of the catalytic triad in the amidase from Nesterenkonia sp.
To be Published
4IZW
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BU of 4izw by Molmil
The E41L mutant of the amidase from Nesterenkonia sp. AN1 showing covalent addition of the acetamide moiety of fluoroacetamide at the active site cysteine
Descriptor: 2-fluoroacetamide, ACETAMIDE, Amidase
Authors:Kimani, S.W, Sewell, B.T.
Deposit date:2013-01-30
Release date:2014-02-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Covalent modifications of the active site cysteine occur as a result of mutating the glutamate of the catalytic triad in the amidase from Nesterenkonia sp.
To be Published
4IZS
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BU of 4izs by Molmil
The C145A mutant of the amidase from Nesterenkonia sp. AN1 in complex with butyramide
Descriptor: Amidase, BUTYRAMIDE, DI(HYDROXYETHYL)ETHER
Authors:Kimani, S.W, Sewell, B.T.
Deposit date:2013-01-30
Release date:2014-02-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Covalent modifications of the active site cysteine occur as a result of mutating the glutamate of the catalytic triad in the amidase from Nesterenkonia sp.
To be Published
7OVG
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BU of 7ovg by Molmil
The C146A variant of an amidase from Pyrococcus horikoshii with bound acetamide
Descriptor: ACETAMIDE, CHLORIDE ION, CN hydrolase domain-containing protein
Authors:Su, S, Makumire, S, Sewell, B.T.
Deposit date:2021-06-14
Release date:2021-07-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The structures of the C146A variant of the amidase from Pyrococcus horikoshii bound to glutaramide and acetamide suggest the basis of amide recognition.
J.Struct.Biol., 214, 2022
7Q49
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BU of 7q49 by Molmil
Local refinement structure of the N-domain of full-length, monomeric, soluble somatic angiotensin I-converting enzyme
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ZINC ION, ...
Authors:Lubbe, L, Sewell, B.T, Sturrock, E.D.
Deposit date:2021-10-29
Release date:2022-07-20
Last modified:2022-08-24
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Cryo-EM reveals mechanisms of angiotensin I-converting enzyme allostery and dimerization.
Embo J., 41, 2022
7Q3Y
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BU of 7q3y by Molmil
Structure of full-length, monomeric, soluble somatic angiotensin I-converting enzyme showing the N- and C-terminal ellipsoid domains
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ...
Authors:Lubbe, L, Sewell, B.T, Sturrock, E.D.
Deposit date:2021-10-29
Release date:2022-07-20
Last modified:2022-08-24
Method:ELECTRON MICROSCOPY (4.34 Å)
Cite:Cryo-EM reveals mechanisms of angiotensin I-converting enzyme allostery and dimerization.
Embo J., 41, 2022
7Q4C
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BU of 7q4c by Molmil
Local refinement structure of the C-domain of full-length, monomeric, soluble somatic angiotensin I-converting enzyme
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ...
Authors:Lubbe, L, Sewell, B.T, Sturrock, E.D.
Deposit date:2021-10-30
Release date:2022-07-20
Last modified:2022-08-24
Method:ELECTRON MICROSCOPY (4.08 Å)
Cite:Cryo-EM reveals mechanisms of angiotensin I-converting enzyme allostery and dimerization.
Embo J., 41, 2022
7Q4E
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BU of 7q4e by Molmil
Local refinement structure of a single N-domain of full-length, dimeric, soluble somatic angiotensin I-converting enzyme
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lubbe, L, Sewell, B.T, Sturrock, E.D.
Deposit date:2021-10-30
Release date:2022-07-20
Last modified:2022-08-24
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:Cryo-EM reveals mechanisms of angiotensin I-converting enzyme allostery and dimerization.
Embo J., 41, 2022
7Q4D
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BU of 7q4d by Molmil
Local refinement structure of the two interacting N-domains of full-length, dimeric, soluble somatic angiotensin I-converting enzyme
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lubbe, L, Sewell, B.T, Sturrock, E.D.
Deposit date:2021-10-30
Release date:2022-07-20
Last modified:2022-08-24
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Cryo-EM reveals mechanisms of angiotensin I-converting enzyme allostery and dimerization.
Embo J., 41, 2022
6FKX
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BU of 6fkx by Molmil
Crystal structure of an acetyl xylan esterase from a desert metagenome
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Acetyl xylan esterase, FORMIC ACID, ...
Authors:Adesioye, F.A, Makhalanyane, T.P, Vikram, S, Sewell, B.T, Schubert, W, Cowan, D.A.
Deposit date:2018-01-24
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structural Characterization and Directed Evolution of a Novel Acetyl Xylan Esterase Reveals Thermostability Determinants of the Carbohydrate Esterase 7 Family.
Appl. Environ. Microbiol., 84, 2018

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