5TTR
 
 | | LEU 55 PRO TRANSTHYRETIN CRYSTAL STRUCTURE | | Descriptor: | TRANSTHYRETIN | | Authors: | Sebastiao, M.P, Saraiva, M.J, Damas, A.M. | | Deposit date: | 1998-04-30 | | Release date: | 1999-06-01 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The crystal structure of amyloidogenic Leu55 --> Pro transthyretin variant reveals a possible pathway for transthyretin polymerization into amyloid fibrils.
J.Biol.Chem., 273, 1998
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1Y1D
 | | Crystal structure of transthyretin in complex with iododiflunisal | | Descriptor: | 2',4'-DIFLUORO-4-HYDROXY-5-IODO-1,1'-BIPHENYL-3-CARBOXYLIC ACID, Transthyretin | | Authors: | Gales, L, Macedo-Ribeiro, S, Arsequell, G, Valencia, G, Saraiva, M.J, Damas, A.M. | | Deposit date: | 2004-11-18 | | Release date: | 2005-07-26 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor.
Biochem.J., 388, 2005
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5FW6
 | | Structure of human transthyretin mutant A108V | | Descriptor: | TRANSTHYRETIN | | Authors: | Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D. | | Deposit date: | 2016-02-12 | | Release date: | 2017-03-08 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.
Sci Rep, 7, 2017
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5FW8
 | | Structure of human transthyretin mutant E89K | | Descriptor: | TRANSTHYRETIN | | Authors: | Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D. | | Deposit date: | 2016-02-12 | | Release date: | 2016-12-28 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of New Non-Amyloidogenic Mutant of Ttr A108V
To be Published
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5FW7
 | | Structure of human transthyretin mutant A109V | | Descriptor: | TRANSTHYRETIN | | Authors: | Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D. | | Deposit date: | 2016-02-12 | | Release date: | 2017-03-08 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Structure of New Non-Amyloidogenic Mutant of Ttr A108V
To be Published
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5FO2
 | | Structure of human transthyretin mutant A108I | | Descriptor: | TRANSTHYRETIN | | Authors: | Varejao, N, Santanna, R, Saraiva, M.J, Gallego, P, Ventura, S, Reverter, D. | | Deposit date: | 2015-11-17 | | Release date: | 2016-11-30 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.449 Å) | | Cite: | Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.
Sci Rep, 7, 2017
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2B16
 | | The crystal structure of 2,4-dinitrophenol in complex with the amyloidogenic variant Transthyretin Tyr78Phe | | Descriptor: | 2,4-DINITROPHENOL, Transthyretin | | Authors: | Morais-de-Sa, E, Neto-Silva, R.M, Pereira, P.J, Saraiva, M.J, Damas, A.M. | | Deposit date: | 2005-09-15 | | Release date: | 2006-07-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
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2B15
 | | The crystal structure of 2,4-dinitrophenol in complex with human transthyretin | | Descriptor: | 2,4-DINITROPHENOL, SULFATE ION, Transthyretin | | Authors: | Morais-de-Sa, E, Neto-Silva, R.M, Pereira, P.J, Saraiva, M.J, Damas, A.M. | | Deposit date: | 2005-09-15 | | Release date: | 2006-07-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
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2B14
 | | The crystal structure of 2,4-dinitrophenol in complex with the amyloidogenic variant Transthyretin Leu 55 Pro | | Descriptor: | 2,4-DINITROPHENOL, Transthyretin | | Authors: | Morais-de-Sa, E, Neto-Silva, R.M, Pereira, P.J, Saraiva, M.J, Damas, A.M. | | Deposit date: | 2005-09-15 | | Release date: | 2006-07-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
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1X7T
 | | Structure of TTR R104H: a non-amyloidogenic variant with protective clinical effects | | Descriptor: | Transthyretin | | Authors: | Neto-Silva, R.M, Macedo-Ribeiro, S, Pereira, P.J.B, Coll, M, Saraiva, M.J, Damas, A.M. | | Deposit date: | 2004-08-16 | | Release date: | 2005-03-22 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | X-ray crystallographic studies of two transthyretin variants: further insights into amyloidogenesis.
Acta Crystallogr.,Sect.D, 61, 2005
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1X7S
 | | The X-ray crystallographic structure of the amyloidogenic variant TTR Tyr78Phe | | Descriptor: | Transthyretin | | Authors: | Neto-Silva, R.M, Macedo-Ribeiro, S, Pereira, P.J.B, Saraiva, M.J, Damas, A.M. | | Deposit date: | 2004-08-16 | | Release date: | 2005-03-22 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | X-ray crystallographic studies of two transthyretin variants: further insights into amyloidogenesis.
Acta Crystallogr.,Sect.D, 61, 2005
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1TT6
 | | The orthorhombic crystal structure of transthyretin in complex with diethylstilbestrol | | Descriptor: | DIETHYLSTILBESTROL, GLYCEROL, SULFATE ION, ... | | Authors: | Morais-de-Sa, E.M, Pereira, P.J.B, Saraiva, M.J, Damas, A.M. | | Deposit date: | 2004-06-22 | | Release date: | 2004-10-12 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The crystal structure of transthyretin in complex with diethylstilbestrol: a promising template for the design of amyloid inhibitors
J.Biol.Chem., 279, 2004
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1TZ8
 | | The monoclinic crystal structure of transthyretin in complex with diethylstilbestrol | | Descriptor: | ACETATE ION, CARBONATE ION, DIETHYLSTILBESTROL, ... | | Authors: | Morais-de-Sa, E.M, Pereira, P.J.B, Saraiva, M.J, Damas, A.M. | | Deposit date: | 2004-07-09 | | Release date: | 2004-10-12 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | The crystal structure of transthyretin in complex with diethylstilbestrol: a promising template for the design of amyloid inhibitors
J.Biol.Chem., 279, 2004
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2H4E
 | | Crystal structure of Cys10 sulfonated transthyretin | | Descriptor: | SULFATE ION, Transthyretin | | Authors: | Gales, L, Damas, A.M. | | Deposit date: | 2006-05-24 | | Release date: | 2007-01-23 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Structural basis for the protective role of sulfite against transthyretin amyloid formation.
Biochim.Biophys.Acta, 1774, 2007
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3SSG
 | | Structure of transthyretin L55P in complex with Zn | | Descriptor: | CACODYLATE ION, Transthyretin, ZINC ION | | Authors: | Castro-Rodrigues, A.F, Gales, L, Damas, A.M. | | Deposit date: | 2011-07-08 | | Release date: | 2011-11-30 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils.
Acta Crystallogr.,Sect.D, 67, 2011
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3B56
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3FCB
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3FC8
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1FHN
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1F86
 | | TRANSTHYRETIN THR119MET PROTEIN STABILISATION | | Descriptor: | 3,5,3',5'-TETRAIODO-L-THYRONINE, TRANSTHYRETIN THR119MET VARIANT | | Authors: | Sebastiao, M.P. | | Deposit date: | 2000-06-29 | | Release date: | 2001-06-29 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution.
J.Mol.Biol., 306, 2001
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1FH2
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1TTR
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