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8PQN
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BU of 8pqn by Molmil
NQO1 bound to RBS-10
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H dehydrogenase [quinone] 1, ~{N}-[4-[(3-methylphenyl)carbonylamino]phenyl]-5-nitro-furan-2-carboxamide
著者Pous, J, Jose-Duran, F, Mayor-Ruiz, C, Riera, A.
登録日2023-07-11
公開日2024-01-10
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders.
Angew.Chem.Int.Ed.Engl., 63, 2024
4R9P
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BU of 4r9p by Molmil
An Expansion to the Smad MH2-family: The structure of the N-MH2 expanded domain
分子名称: RE28239p
著者Beich-Frandsen, M, Aragon, E, Llimargas, M, Benach, J, Riera, A, Macias, M.J.
登録日2014-09-06
公開日2015-04-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.592 Å)
主引用文献Structure of the N-terminal domain of the protein Expansion: an 'Expansion' to the Smad MH2
Acta Crystallogr.,Sect.D, 71, 2015
6WGI
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BU of 6wgi by Molmil
Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on DNA at 10.5 A resolution
分子名称: Cell division control protein 6, Cell division cycle protein CDT1, DNA (34-MER), ...
著者Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C.
登録日2020-04-05
公開日2020-07-15
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (10 Å)
主引用文献Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
6WGG
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BU of 6wgg by Molmil
Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation)
分子名称: Cell division control protein 6, Cell division cycle protein CDT1, DNA (41-MER), ...
著者Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C.
登録日2020-04-05
公開日2020-07-15
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (8.1 Å)
主引用文献Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
6WGC
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BU of 6wgc by Molmil
Atomic model of semi-attached mutant OCCM-DNA complex (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation)
分子名称: Cell division control protein 6, DNA (41-MER), DNA replication licensing factor MCM3, ...
著者Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C.
登録日2020-04-05
公開日2020-07-15
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
5V8F
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BU of 5v8f by Molmil
Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1
分子名称: Cell division control protein 6, Cell division cycle protein CDT1, DNA (39-MER), ...
著者Yuan, Z, Riera, A, Bai, L, Sun, J, Spanos, C, Chen, Z.A, Barbon, M, Rappsilber, J, Stillman, B, Speck, C, Li, H.
登録日2017-03-21
公開日2017-05-10
最終更新日2020-04-22
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.
Nat. Struct. Mol. Biol., 24, 2017
6WGF
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BU of 6wgf by Molmil
Atomic model of mutant Mcm2-7 hexamer with Mcm6 WHD truncation
分子名称: DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
著者Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C.
登録日2020-04-05
公開日2020-07-15
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (7.7 Å)
主引用文献Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
6Y1Q
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BU of 6y1q by Molmil
Cortistatin analog with improved immunoregulatory activity
分子名称: Analog 5, OCTANOIC ACID (CAPRYLIC ACID)
著者Rol, A.
登録日2020-02-13
公開日2021-01-27
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease.
Nat Commun, 12, 2021
6FQP
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BU of 6fqp by Molmil
Crystal structure of TALE homeobox domain transcription factor TGIF1 with its consensus DNA
分子名称: CALCIUM ION, DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), Homeobox protein TGIF1
著者Guca, E, Macias, M.J.
登録日2018-02-14
公開日2018-07-25
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.
Nucleic Acids Res., 46, 2018
6FQQ
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BU of 6fqq by Molmil
Crystal structure of TALE homeobox domain transcription factor TGIF1 double alanine mutant bound to its consensus DNA
分子名称: CHLORIDE ION, DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), Homeobox protein TGIF1
著者Guca, E, Macias, M.J.
登録日2018-02-14
公開日2018-07-25
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.25000262 Å)
主引用文献TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.
Nucleic Acids Res., 46, 2018

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件を2024-04-24に公開中

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