8PQN

NQO1 bound to RBS-10

Summary for 8PQN

Entry DOI	10.2210/pdb8pqn/pdb
Descriptor	NAD(P)H dehydrogenase [quinone] 1, FLAVIN-ADENINE DINUCLEOTIDE, ~{N}-[4-[(3-methylphenyl)carbonylamino]phenyl]-5-nitro-furan-2-carboxamide (3 entities in total)
Functional Keywords	nqo1, rbs-10, quinone reductase, degrader resistance, prodrug, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	125407.43
Authors	Pous, J.,Jose-Duran, F.,Mayor-Ruiz, C.,Riera, A. (deposition date: 2023-07-11, release date: 2024-01-10, Last modification date: 2024-03-20)
Primary citation	Barbosa, B.M.G.,Sfyaki, A.,Rafael, S.,Jose-Duran, F.,Pous, J.,Sanchez-Zarzalejo, C.,Perez-Lopez, C.,Vilanova, M.,Cigler, M.,Gay, M.,Vilaseca, M.,Winter, G.E.,Riera, A.,Mayor-Ruiz, C. Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders. Angew.Chem.Int.Ed.Engl., 63:e202316730-e202316730, 2024 Cited by PubMed: 38153885 DOI: 10.1002/anie.202316730 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.8 Å)

Structure validation