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7TUS
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BU of 7tus by Molmil
Sculpting a uniquely reactive cysteine residue for site-specific antibody conjugation
分子名称: Antibody Heavy Chain, Antibody Light Chain, DI(HYDROXYETHYL)ETHER, ...
著者Park, H, Rader, C.
登録日2022-02-03
公開日2022-06-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Sculpting a Uniquely Reactive Cysteine Residue for Site-Specific Antibody Conjugation.
Bioconjug.Chem., 33, 2022
2X7L
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BU of 2x7l by Molmil
Implications of the HIV-1 Rev dimer structure at 3.2A resolution for multimeric binding to the Rev response element
分子名称: FAB HEAVY CHAIN, FAB LIGHT CHAIN, PROTEIN REV
著者DiMattia, M.A, Watts, N.R, Stahl, S.J, Rader, C, Wingfield, P.T, Stuart, D.I, Steven, A.C, Grimes, J.M.
登録日2010-03-01
公開日2010-03-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.17 Å)
主引用文献Implications of the HIV-1 Rev Dimer Structure at 3. 2 A Resolution for Multimeric Binding to the Rev Response Element.
Proc.Natl.Acad.Sci.USA, 107, 2010
6U85
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BU of 6u85 by Molmil
Site-specific lysine arylation as an alternative bioconjugation strategy for chemically programmed antibodies and antibody-drug conjugates
分子名称: Antibody Fab heavy chain, GLYCEROL, antibody Fab Light chain
著者Park, H, Rader, C.
登録日2019-09-04
公開日2019-11-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Site-Specific Lysine Arylation as an Alternative Bioconjugation Strategy for Chemically Programmed Antibodies and Antibody-Drug Conjugates.
Bioconjug.Chem., 30, 2019
6DZR
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BU of 6dzr by Molmil
Crystal structure of h38C2 K99R mutation
分子名称: CITRATE ANION, SULFATE ION, h38c2 heavy chain, ...
著者Park, H, Rader, C.
登録日2018-07-05
公開日2019-07-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues.
Cell Chem Biol, 26, 2019
6BA5
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BU of 6ba5 by Molmil
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
分子名称: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain Heavy chain, antibody R11, ...
著者Park, H, Rader, C.
登録日2017-10-12
公開日2018-06-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BAN
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BU of 6ban by Molmil
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
分子名称: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain R11 Heavy chain, Variable domain of R11 Light Chain
著者Park, H, Rader, C.
登録日2017-10-14
公開日2018-06-13
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6OSV
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BU of 6osv by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
分子名称: Antibody heavy chain variable region, Antibody light chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
著者Park, H, Rader, C.
登録日2019-05-02
公開日2020-04-01
最終更新日2020-05-13
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6OSH
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BU of 6osh by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
分子名称: Antibody Light chain variable region, Antibody heavy chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
著者Park, H, Rader, C.
登録日2019-05-01
公開日2020-04-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.117 Å)
主引用文献Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6OSN
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BU of 6osn by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
分子名称: ACETATE ION, Tyrosine-protein kinase transmembrane receptor ROR2
著者Park, H, Rader, C.
登録日2019-05-01
公開日2020-04-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.083 Å)
主引用文献Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6CLW
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BU of 6clw by Molmil
Crystal structure of TnmH
分子名称: O-methyltransferase
著者Chang, C.Y, Annaval, T, Adhikari, A, Yan, X, Shen, B.
登録日2018-03-02
公開日2019-03-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Characterization of TnmH as anO-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates.
J.Med.Chem., 63, 2020
6CLX
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BU of 6clx by Molmil
Crystal structure of TnmH in complex with SAM
分子名称: O-methyltransferase, S-ADENOSYLMETHIONINE
著者Chang, C.Y, Annaval, T, Adhikari, A, Yan, X, Shen, B.
登録日2018-03-02
公開日2019-03-06
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Characterization of TnmH as anO-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates.
J.Med.Chem., 63, 2020

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件を2024-04-24に公開中

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