Search by PDB author

Structure of GRP94 N-terminal Domain bound to resorcinylic inhibitor BnIm.
Descriptor:	1,2-ETHANEDIOL, Endoplasmin, MAGNESIUM ION, ...
Authors:	Que, N.S, Gewirth, D.T.
Deposit date:	2017-07-31
Release date:	2018-04-18
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.748 Å)
Cite:	Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding. J. Med. Chem., 61, 2018

Structure of human Hsp90-alpha bound to resorcinylic inhibitor BnIm
Descriptor:	1,2-ETHANEDIOL, FORMIC ACID, Heat shock protein HSP 90-alpha, ...
Authors:	Que, N.S, Gewirth, D.T.
Deposit date:	2017-05-26
Release date:	2018-04-18
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.792 Å)
Cite:	Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding. J. Med. Chem., 61, 2018

Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54
Descriptor:	8-[(2,4-dimethylphenyl)sulfanyl]-3-pent-4-yn-1-yl-3H-purin-6-amine, Endoplasmin, GLYCEROL, ...
Authors:	Seidler, P.M, Gewirth, D.T.
Deposit date:	2010-07-22
Release date:	2011-10-05
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat.Chem.Biol., 9, 2013

Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor PU-H54
Descriptor:	8-[(2,4-dimethylphenyl)sulfanyl]-3-pent-4-yn-1-yl-3H-purin-6-amine, HSP90AA1 protein
Authors:	Seidler, P.M, Gewirth, D.T.
Deposit date:	2010-07-19
Release date:	2011-10-05
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.47 Å)
Cite:	Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat.Chem.Biol., 9, 2013