4G6B
| Three dimensional structure analysis of the type II citrate synthase from e.coli | 分子名称: | Citrate synthase, SULFATE ION | 著者 | Nguyen, N.T, Maurus, R, Stokell, D.J, Ayed, A, Duckworth, H.W, Brayer, G.D. | 登録日 | 2012-07-18 | 公開日 | 2013-11-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Comparative Analysis of Folding and Substrate Binding Sites between Regulated Hexameric Type II Citrate Synthases and Unregulated Dimeric Type I Enzymes. Biochemistry, 40, 2001
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1CPU
| SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 5-HYDROXYMETHYL-CHONDURITOL, ... | 著者 | Brayer, G.D, Sidhu, G, Maurus, R, Rydberg, E.H, Braun, C, Wang, Y, Nguyen, N.T, Overall, C.M, Withers, S.G. | 登録日 | 1999-06-07 | 公開日 | 1999-06-14 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry, 39, 2000
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2CPU
| SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT | 分子名称: | ALPHA-AMYLASE, CALCIUM ION, CHLORIDE ION | 著者 | Brayer, G.D, Sidhu, G, Maurus, R, Rydberg, E.H, Braun, C, Wang, Y, Nguyen, N.T, Overall, C.M, Withers, S.G. | 登録日 | 1999-06-08 | 公開日 | 2001-06-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry, 39, 2000
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1NXE
| A Novel NADH Allosteric Regulator Site is Found on the Surface of the Hexameric Type II Phe383Ala Variant of Citrate Synthase | 分子名称: | Citrate synthase, SULFATE ION | 著者 | Maurus, R, Nguyen, N.T, Stokell, D.J, Ayed, A, Hultin, P.G, Duckworth, H.W, Brayer, G.D. | 登録日 | 2003-02-10 | 公開日 | 2003-04-08 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Insights into the evolution of allosteric properties. The NADH binding site of hexameric type II citrate synthases. Biochemistry, 42, 2003
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1NXG
| The F383A variant of type II Citrate Synthase complexed with NADH | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Citrate synthase, SULFATE ION | 著者 | Maurus, R, Nguyen, N.T, Stokell, D.J, Ayed, A, Hultin, P.G, Duckworth, H.W, Brayer, G.D. | 登録日 | 2003-02-10 | 公開日 | 2003-04-08 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Insights into the evolution of allosteric properties. The NADH binding site of hexameric type II citrate synthases. Biochemistry, 42, 2003
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1OWC
| Three Dimensional Structure Analysis Of The R109L Variant of the Type II Citrate Synthase From E. Coli | 分子名称: | Citrate synthase, SULFATE ION | 著者 | Stokell, D.J, Donald, L.J, Maurus, R, Nguyen, N.T, Sadler, G, Choudhary, K, Hultin, P.G, Brayer, G.D, Duckworth, H.W. | 登録日 | 2003-03-28 | 公開日 | 2004-05-18 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Probing the roles of key residues in the unique regulatory NADH binding site of type II citrate synthase of Escherichia coli. J.Biol.Chem., 278, 2003
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1OWB
| Three Dimensional Structure Analysis Of The Variant R109L NADH Complex of Type II Citrate Synthase From E. Coli | 分子名称: | Citrate synthase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION | 著者 | Stokell, D.J, Donald, L.J, Maurus, R, Nguyen, N.T, Sadler, G, Choudhary, K, Hultin, P.G, Brayer, G.D, Duckworth, H.W. | 登録日 | 2003-03-28 | 公開日 | 2004-05-18 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Probing the roles of key residues in the unique regulatory NADH binding site of type II citrate synthase of Escherichia coli. J.Biol.Chem., 278, 2003
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3CPU
| SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT | 分子名称: | CALCIUM ION, CHLORIDE ION, Pancreatic alpha-amylase, ... | 著者 | Brayer, G.D, Sidhu, G, Maurus, R, Rydberg, E.H, Braun, C, Wang, Y, Nguyen, N.T, Overall, C.M, Withers, S.G. | 登録日 | 1999-06-08 | 公開日 | 2001-06-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry, 39, 2000
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4N8W
| cathepsin K - chondroitin sulfate complex | 分子名称: | 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid, Cathepsin K | 著者 | Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. | 登録日 | 2013-10-18 | 公開日 | 2014-11-26 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structural basis of collagen fiber degradation by cathepsin K. Proc.Natl.Acad.Sci.USA, 111, 2014
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4N79
| Structure of Cathepsin K-dermatan sulfate complex | 分子名称: | Cathepsin K, alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose | 著者 | Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. | 登録日 | 2013-10-15 | 公開日 | 2014-11-26 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Structural basis of collagen fiber degradation by cathepsin K. Proc.Natl.Acad.Sci.USA, 111, 2014
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6PXF
| Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution | 分子名称: | 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonic acid, Cathepsin K | 著者 | Law, S, Aguda, A.H, Nguyen, N.T, Brayer, G.D, Bromme, D. | 登録日 | 2019-07-25 | 公開日 | 2020-07-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution To Be Published
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5TUN
| Crystal structure of uninhibited human Cathepsin K at 1.62 Angstrom resolution | 分子名称: | Cathepsin K | 著者 | Aguda, A.H, Kruglyak, N, Nguyen, N.T, Law, S, Bromme, D, Brayer, G.D. | 登録日 | 2016-11-06 | 公開日 | 2017-01-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib. Biochem. J., 474, 2017
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4YV8
| Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal | 分子名称: | Cathepsin K, Lichostatinal, SULFATE ION | 著者 | Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. | 登録日 | 2015-03-19 | 公開日 | 2016-05-04 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts. J.Nat.Prod., 79, 2016
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4YVA
| Cathepsin K co-crystallized with actinomycetes extract | 分子名称: | Cathepsin K, SULFATE ION | 著者 | Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. | 登録日 | 2015-03-19 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts. J.Nat.Prod., 79, 2016
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1AZI
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1BVV
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1BJE
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2BVV
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4W93
| Human pancreatic alpha-amylase in complex with montbretin A | 分子名称: | CALCIUM ION, CHLORIDE ION, Montbretin A, ... | 著者 | Williams, L.K, Caner, S, Brayer, G.D. | 登録日 | 2014-08-27 | 公開日 | 2015-07-15 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.352 Å) | 主引用文献 | The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif. Nat.Chem.Biol., 11, 2015
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5T6U
| Crystal structure of mouse cathepsin K at 2.9 Angstroms resolution. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin K, SULFATE ION | 著者 | Law, S, Aguda, A, Nguyen, N, Brayer, G, Bromme, D. | 登録日 | 2016-09-01 | 公開日 | 2017-01-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib. Biochem. J., 474, 2017
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5TDI
| Crystal structure of Cathepsin K with a covalently-linked inhibitor at 1.4 Angstrom resolution. | 分子名称: | 4-fluoro-N-{1-[(Z)-iminomethyl]cyclopropyl}-N~2~-{(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl }-L-leucinamide, Cathepsin K | 著者 | Law, S, Aguda, A, Nguyen, N, Brayer, G, Bromme, D. | 登録日 | 2016-09-19 | 公開日 | 2017-01-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib. Biochem. J., 474, 2017
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5EMY
| Human Pancreatic Alpha-Amylase in complex with the mechanism based inactivator glucosyl epi-cyclophellitol | 分子名称: | (1R,2R,3S,5R,6S)-2,3,5-trihydroxy-6-(hydroxymethyl)cyclohexyl alpha-D-glucopyranoside, CALCIUM ION, CHLORIDE ION, ... | 著者 | Caner, S, Brayer, G.D. | 登録日 | 2015-11-06 | 公開日 | 2016-07-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.231 Å) | 主引用文献 | Glucosyl epi-cyclophellitol allows mechanism-based inactivation and structural analysis of human pancreatic alpha-amylase. Febs Lett., 590, 2016
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6DV5
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6E02
| WT swMb-MeNO | 分子名称: | Myoglobin, NITROSOMETHANE, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Herrera, V.E. | 登録日 | 2018-07-05 | 公開日 | 2019-07-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Insights into Nitrosoalkane Binding to Myoglobin Provided by Crystallography of Wild-Type and Distal Pocket Mutant Derivatives. Biochemistry, 62, 2023
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6E03
| sperm whale myoglobin nitrosoethane adduct | 分子名称: | CHLORIDE ION, Myoglobin, NITROSOETHANE, ... | 著者 | Herrera, V.E. | 登録日 | 2018-07-05 | 公開日 | 2019-07-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Insights into Nitrosoalkane Binding to Myoglobin Provided by Crystallography of Wild-Type and Distal Pocket Mutant Derivatives. Biochemistry, 62, 2023
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