1YJO
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![BU of 1yjo by Molmil](/molmil-images/mine/1yjo) | Structure of NNQQNY from yeast prion Sup35 with zinc acetate | Descriptor: | ACETIC ACID, Eukaryotic peptide chain release factor GTP-binding subunit, ZINC ION | Authors: | Nelson, R, Sawaya, M.R, Balbirnie, M, Madsen, A.O, Riekel, C, Grothe, R, Eisenberg, D. | Deposit date: | 2005-01-15 | Release date: | 2005-06-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structure of the cross-beta spine of amyloid-like fibrils. Nature, 435, 2005
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1YJP
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![BU of 1yjp by Molmil](/molmil-images/mine/1yjp) | Structure of GNNQQNY from yeast prion Sup35 | Descriptor: | Eukaryotic peptide chain release factor GTP-binding subunit | Authors: | Nelson, R, Sawaya, M.R, Balbirnie, M, Madsen, A.O, Riekel, C, Grothe, R, Eisenberg, D. | Deposit date: | 2005-01-15 | Release date: | 2005-06-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of the cross-beta spine of amyloid-like fibrils. Nature, 435, 2005
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2OLX
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![BU of 2olx by Molmil](/molmil-images/mine/2olx) | |
2R9M
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![BU of 2r9m by Molmil](/molmil-images/mine/2r9m) | Cathepsin S complexed with Compound 15 | Descriptor: | Cathepsin S, N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide | Authors: | Ward, Y.D, Emmanuel, M.J, Thomson, D.S, Liu, W, Bekkali, Y, Frye, L.L, Girardot, M, Morwick, T, Young, E.R.R, Zindell, R, Hrapchak, M, DeTuri, M, White, A, Crane, K.M, White, D.M, Wang, Y, Hao, M.-H, Grygon, C.A, Labadia, M.E, Wildeson, J, Freeman, D, Nelson, R, Capolino, A, Peterson, J.D, Raymond, E.L, Brown, M.L, Spero, D.M. | Deposit date: | 2007-09-13 | Release date: | 2007-12-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Design and Synthesis of Reversible Inhibitors of Cathepsin S: alpha,alpha-Disubstitution at the P1 Residue Provides Potent Inhibitors in Cellular Assays and In Vivo Models of Antigen Presentation To be Published
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2R9O
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![BU of 2r9o by Molmil](/molmil-images/mine/2r9o) | Cathepsin S complexed with Compound 8 | Descriptor: | Cathepsin S, N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide | Authors: | Ward, Y.D, Emmanuel, M.J, Thomson, D.S, Liu, W, Bekkali, Y, Frye, L.L, Girardot, M, Morwick, T, Young, E.R.R, Zindell, R, Hrapchak, M, DeTuri, M, White, A, Crane, K.M, White, D.M, Wang, Y, Hao, M.-H, Grygon, C.A, Labadia, M.E, Wildeson, J, Freeman, D, Nelson, R, Capolino, A, Peterson, J.D, Raymond, E.L, Brown, M.L, Spero, D.M. | Deposit date: | 2007-09-13 | Release date: | 2007-12-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design and Synthesis of Reversible Inhibitors of Cathepsin S: alpha,alpha-Disubstitution at the P1 Residue Provides Potent Inhibitors in Cellular Assays and In Vivo Models of Antigen Presentation to be published
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2R9N
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![BU of 2r9n by Molmil](/molmil-images/mine/2r9n) | Cathepsin S complexed with Compound 26 | Descriptor: | Cathepsin S, N-[(1S)-2-{[(3S)-1-benzyl-3-cyanopyrrolidin-3-yl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide | Authors: | Ward, Y.D, Emmanuel, M.J, Thomson, D.S, Liu, W, Bekkali, Y, Frye, L.L, Girardot, M, Morwick, T, Young, E.R.R, Zindell, R, Hrapchak, M, DeTuri, M, White, A, Crane, K.M, White, D.M, Wang, Y, Hao, M.-H, Grygon, C.A, Labadia, M.E, Wildeson, J, Freeman, D, Nelson, R, Capolino, A, Peterson, J.D, Raymond, E.L, Brown, M.L, Spero, D.M. | Deposit date: | 2007-09-13 | Release date: | 2007-12-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design and Synthesis of Reversible Inhibitors of Cathepsin S: alpha,alpha-Disubstitution at the P1 Residue Provides Potent Inhibitors in Cellular Assays and In Vivo Models of Antigen Presentation to be published
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2OMM
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2ONX
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![BU of 2onx by Molmil](/molmil-images/mine/2onx) | NNQQ peptide corresponding to residues 8-11 of yeast prion sup35 (alternate crystal form) | Descriptor: | peptide corresponding to residues 8-11 of yeast prion sup35 | Authors: | Sawaya, M.R, Sambashivan, S, Nelson, R, Ivanova, M, Sievers, S.A, Apostol, M.I, Thompson, M.J, Balbirnie, M, Wiltzius, J.J, McFarlane, H, Madsen, A.O, Riekel, C, Eisenberg, D. | Deposit date: | 2007-01-24 | Release date: | 2007-02-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature, 447, 2007
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5IIW
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![BU of 5iiw by Molmil](/molmil-images/mine/5iiw) | Corkscrew assembly of SOD1 residues 28-38 without potassium iodide | Descriptor: | Superoxide dismutase [Cu-Zn] | Authors: | Sangwan, S, Zhao, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2016-03-01 | Release date: | 2017-06-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7CK5
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![BU of 7ck5 by Molmil](/molmil-images/mine/7ck5) | Solution structure of 28 amino acid polypeptide (354-381) in Plantago asiatica mosaic virus replicase bound to SDS micelle | Descriptor: | PlAMV replicase peptide from RNA-dependent RNA polymerase | Authors: | Komatsu, K, Sasaki, N, Yoshida, T, Suzuki, K, Masujima, Y, Hashimoto, M, Watanabe, S, Tochio, N, Kigawa, T, Yamaji, Y, Oshima, K, Namba, S, Nelson, R, Arie, T. | Deposit date: | 2020-07-15 | Release date: | 2021-07-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Identification of a Proline-Kinked Amphipathic alpha-Helix Downstream from the Methyltransferase Domain of a Potexvirus Replicase and Its Role in Virus Replication and Perinuclear Complex Formation. J.Virol., 95, 2021
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5DLI
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![BU of 5dli by Molmil](/molmil-images/mine/5dli) | Corkscrew assembly of SOD1 residues 28-38 | Descriptor: | GLYCEROL, IODIDE ION, Superoxide dismutase [Cu-Zn] | Authors: | Sangwan, S, Zhao, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2015-09-05 | Release date: | 2016-09-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3FPO
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![BU of 3fpo by Molmil](/molmil-images/mine/3fpo) | |
3FTH
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![BU of 3fth by Molmil](/molmil-images/mine/3fth) | |
3FTL
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![BU of 3ftl by Molmil](/molmil-images/mine/3ftl) | |
3FTR
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![BU of 3ftr by Molmil](/molmil-images/mine/3ftr) | |
3FR1
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![BU of 3fr1 by Molmil](/molmil-images/mine/3fr1) | |
3FVA
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![BU of 3fva by Molmil](/molmil-images/mine/3fva) | NNQNTF segment from elk prion | Descriptor: | Major prion protein | Authors: | Apostol, M.I, Eisenberg, D. | Deposit date: | 2009-01-15 | Release date: | 2009-06-30 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.458 Å) | Cite: | Molecular mechanisms for protein-encoded inheritance. Nat.Struct.Mol.Biol., 16, 2009
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3FTK
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3FOD
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3KKV
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![BU of 3kkv by Molmil](/molmil-images/mine/3kkv) | Structure of PKA with a protein Kinase B-selective inhibitor. | Descriptor: | (2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxy}-3-(1H-indol-3-yl)propan-2-amine, PKI kinase inhibitor, cAMP-dependent protein kinase catalytic subunit alpha | Authors: | Elkins, P.A, Concha, N.O. | Deposit date: | 2009-11-06 | Release date: | 2010-12-22 | Last modified: | 2014-12-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of PKA with a protein Kinase B-selective inhibitor. To be Published
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2OMQ
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2ONV
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2OL9
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![BU of 2ol9 by Molmil](/molmil-images/mine/2ol9) | |
2OMP
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![BU of 2omp by Molmil](/molmil-images/mine/2omp) | |
2ON9
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![BU of 2on9 by Molmil](/molmil-images/mine/2on9) | |