2R9M

Cathepsin S complexed with Compound 15

Summary for 2R9M

• Entry DOI: 10.2210/pdb2r9m/pdb
• Related: 2R9N 2R9O
• Descriptor: Cathepsin S, N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide (3 entities in total)
• Functional Keywords: hydrolase, cathepsin, protease, glycoprotein, lysosome, polymorphism, thiol protease, zymogen
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 50206.41

Authors

Ward, Y.D.,Emmanuel, M.J.,Thomson, D.S.,Liu, W.,Bekkali, Y.,Frye, L.L.,Girardot, M.,Morwick, T.,Young, E.R.R.,Zindell, R.,Hrapchak, M.,DeTuri, M.,White, A.,Crane, K.M.,White, D.M.,Wang, Y.,Hao, M.-H.,Grygon, C.A.,Labadia, M.E.,Wildeson, J.,Freeman, D.,Nelson, R.,Capolino, A.,Peterson, J.D.,Raymond, E.L.,Brown, M.L.,Spero, D.M. (deposition date: 2007-09-13, release date: 2007-12-18, Last modification date: 2024-10-16)

• Primary citation: Ward, Y.D.,Emmanuel, M.J.,Thomson, D.S.,Liu, W.,Bekkali, Y.,Frye, L.L.,Girardot, M.,Morwick, T.,Young, E.R.R.,Zindell, R.,Hrapchak, M.,DeTuri, M.,White, A.,Crane, K.M.,White, D.M.,Wang, Y.,Hao, M.-H.,Grygon, C.A.,Labadia, M.E.,Wildeson, J.,Freeman, D.,Nelson, R.,Capolino, A.,Peterson, J.D.,Raymond, E.L.,Brown, M.L.,Spero, D.M.; Design and Synthesis of Reversible Inhibitors of Cathepsin S: alpha,alpha-Disubstitution at the P1 Residue Provides Potent Inhibitors in Cellular Assays and In Vivo Models of Antigen Presentation; To be Published,

Experimental method

X-RAY DIFFRACTION (1.97 Å)