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4QWT
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BU of 4qwt by Molmil
Anaerobic crystal structure of delta413-417:GS LOX in complex with arachidonate
分子名称: ACETATE ION, ARACHIDONIC ACID, Allene oxide synthase-lipoxygenase protein, ...
著者Neau, D.B, Newcomer, M.E.
登録日2014-07-17
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.002 Å)
主引用文献Crystal Structure of a Lipoxygenase in Complex with Substrate: THE ARACHIDONIC ACID-BINDING SITE OF 8R-LIPOXYGENASE.
J.Biol.Chem., 289, 2014
3FG1
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BU of 3fg1 by Molmil
Crystal structure of Delta413-417:GS LOX
分子名称: ACETIC ACID, Allene oxide synthase-lipoxygenase protein, CALCIUM ION, ...
著者Neau, D.B, Newcomer, M.E.
登録日2008-12-04
公開日2009-08-18
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity.
Biochemistry, 48, 2009
3FG4
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BU of 3fg4 by Molmil
Crystal structure of Delta413-417:GS I805A LOX
分子名称: ACETIC ACID, ARACHIDONIC ACID, Allene oxide synthase-lipoxygenase protein, ...
著者Neau, D.B, Newcomer, M.E.
登録日2008-12-04
公開日2009-08-18
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity.
Biochemistry, 48, 2009
3FG3
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BU of 3fg3 by Molmil
Crystal structure of Delta413-417:GS I805W LOX
分子名称: ACETIC ACID, Allene oxide synthase-lipoxygenase protein, CALCIUM ION, ...
著者Neau, D.B, Newcomer, M.E.
登録日2008-12-04
公開日2009-08-18
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity.
Biochemistry, 48, 2009
2EI3
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BU of 2ei3 by Molmil
Anaerobic Crystal Structure Analysis of the 1,2-dihydroxynaphthalene dioxygenase from Pseudomonas sp. strain C18 complexes with 2,3-dihydroxybiphenyl
分子名称: 1,2-dihydroxynaphthalene dioxygenase, BIPHENYL-2,3-DIOL, FE (II) ION, ...
著者Neau, D.B, Kelker, M.S, Colbert, C.L, Bolin, J.T.
登録日2007-03-10
公開日2008-02-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural explanation for success and failure in the enzymatic ring-cleavage of 3,4 dihydroxybiphenyl and related PCB metabolites
To be Published
2EI0
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BU of 2ei0 by Molmil
Anaerobic Crystal Structure Analysis of 1,2-dihydroxynaphthalene dioxygenase from Pseudomonas sp. strain C18 complexed with 3,4-dihydroxybiphenyl
分子名称: 1,1'-BIPHENYL-3,4-DIOL, 1,2-dihydroxynaphthalene dioxygenase, FE (II) ION, ...
著者Neau, D.B, Kelker, M.S, Colbert, C.L, Bolin, J.T.
登録日2007-03-10
公開日2008-02-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural explanation for success and failure in the enzymatic ring-cleavage of 3,4 dihydroxybiphenyl and related PCB metabolites
To be Published
2EI2
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BU of 2ei2 by Molmil
Crystal Structure Analysis of the 1,2-dihydroxynaphthalene dioxygenase from Pseudomonas sp. stain C18
分子名称: 1,2-dihydroxynaphthalene dioxygenase, FE (II) ION, GLYCEROL, ...
著者Neau, D.B, Kelker, M.S, Colbert, C.L, Bolin, J.T.
登録日2007-03-10
公開日2008-02-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Structural explanation for success and failure in the enzymatic ring-cleavage of 3,4 dihydroxybiphenyl and related PCB metabolites
To be Published
2EI1
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BU of 2ei1 by Molmil
Anaerobic Crystal Structure Analysis of the 1,2-dihydroxynaphthalene dioxygeanse of Pseudomonas sp. strain C18 complexes to 1,2-dihydroxynaphthalene
分子名称: 1,2-dihydroxynaphthalene dioxygenase, FE (II) ION, GLYCEROL, ...
著者Neau, D.B, Kelker, M.S, Colbert, C.L, Bolin, J.T.
登録日2007-03-10
公開日2008-02-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Structural explanation for success and failure in the enzymatic ring-cleavage of 3,4 dihydroxybiphenyl and related PCB metabolites.
To be Published
2EHZ
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BU of 2ehz by Molmil
Anaerobic Crystal Structure Analysis of 1,2-dihydroxynaphthalene dioxygenase from Pseudomonas sp. strain C18 complexed with 4-methylcatechol
分子名称: 1,2-ETHANEDIOL, 1,2-dihydroxynaphthalene dioxygenase, 4-METHYLCATECHOL, ...
著者Neau, D.B, Kelker, M.S, Colbert, C.L, Bolin, J.T.
登録日2007-03-10
公開日2008-02-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structural explanation for success and failure in the enzymatic ring-cleavage of 3,4 dihydroxybiphenyl and related PCB metabolites
To be Published
6N2W
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BU of 6n2w by Molmil
The structure of Stable-5-Lipoxygenase bound to NDGA
分子名称: 4-[(2R,3S)-3-[(3,4-DIHYDROXYPHENYL)METHYL]-2-METHYLBUTYL]BENZENE-1,2-DIOL, Arachidonate 5-lipoxygenase, FE (II) ION
著者Newcomer, M.E, Gilbert, N.C, Neau, D.B.
登録日2018-11-14
公開日2020-05-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products.
Nat.Chem.Biol., 16, 2020
7LAF
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BU of 7laf by Molmil
15-lipoxygenase-2 loop mutant bound to imidazole-based inhibitor
分子名称: 3-{[(4-methylphenyl)methyl]sulfanyl}-1-phenyl-1H-1,2,4-triazole, MANGANESE (II) ION, Polyunsaturated fatty acid lipoxygenase ALOX15B
著者Newcomer, M.E, Gilbert, N.C, Neau, D.B.
登録日2021-01-06
公開日2022-01-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
Bioorg.Med.Chem., 46, 2021
4RZQ
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BU of 4rzq by Molmil
Structural Analysis of Substrate, Reaction Intermediate and Product Binding in Haemophilus influenzae Biotin Carboxylase
分子名称: ADENOSINE-5'-DIPHOSPHATE, Biotin carboxylase, methyl (3aS,4S,6aR)-4-(5-methoxy-5-oxopentyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazole-1-carboxylate
著者Broussard, T.C, Pakhomova, S, Neau, D.B, Champion, T.S, Bonnot, R, Waldrop, G.L.
登録日2014-12-23
公開日2015-06-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structural Analysis of Substrate, Reaction Intermediate, and Product Binding in Haemophilus influenzae Biotin Carboxylase.
Biochemistry, 54, 2015
2ORX
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BU of 2orx by Molmil
Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin
分子名称: Neuropilin-1
著者Vander Kooi, C.W, Jusino, M.A, Perman, B, Neau, D.B, Bellamy, H.D, Leahy, D.J.
登録日2007-02-05
公開日2007-04-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for ligand and heparin binding to neuropilin B domains
Proc.Natl.Acad.Sci.Usa, 104, 2007
2ORZ
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BU of 2orz by Molmil
Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin
分子名称: Neuropilin-1, Tuftsin
著者Vander Kooi, C.W, Jusino, M.A, Perman, B, Neau, D.B, Bellamy, H.D, Leahy, D.J.
登録日2007-02-05
公開日2007-04-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis for ligand and heparin binding to neuropilin B domains.
Proc.Natl.Acad.Sci.Usa, 104, 2007
4HR7
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BU of 4hr7 by Molmil
Crystal Structure of Biotin Carboxyl Carrier Protein-Biotin Carboxylase Complex from E.coli
分子名称: 1,2-ETHANEDIOL, Biotin carboxyl carrier protein of acetyl-CoA carboxylase, Biotin carboxylase, ...
著者Broussard, T.C, Kobe, M.J, Pakhomova, S, Neau, D.B, Price, A.E, Champion, T.S, Waldrop, G.L.
登録日2012-10-26
公開日2013-03-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.495 Å)
主引用文献The three-dimensional structure of the biotin carboxylase-biotin carboxyl carrier protein complex of E. coli acetyl-CoA carboxylase.
Structure, 21, 2013
3V99
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BU of 3v99 by Molmil
S663D Stable-5-LOX in complex with Arachidonic Acid
分子名称: ARACHIDONIC ACID, Arachidonate 5-lipoxygenase, FE (II) ION
著者Gilbert, N.C, Rui, Z, Neau, D.B, Waight, M, Bartlett, S.G, Boeglin, W.E, Brash, A.R, Newcomer, M.E.
登録日2011-12-23
公開日2012-05-02
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.252 Å)
主引用文献Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.
Faseb J., 26, 2012
3V92
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BU of 3v92 by Molmil
S663A Stable-5-LOX
分子名称: Arachidonate 5-lipoxygenase, FE (II) ION
著者Gilbert, N.C, Rui, Z, Neau, D.B, Waight, M, Bartlett, S.G, Boeglin, W.E, Brash, A.R, Newcomer, M.E.
登録日2011-12-23
公開日2012-05-02
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.
Faseb J., 26, 2012
3V98
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S663D Stable-5-LOX
分子名称: Arachidonate 5-lipoxygenase, FE (II) ION
著者Gilbert, N.C, Rui, Z, Neau, D.B, Waight, M, Bartlett, S.G, Boeglin, W.E, Brash, A.R, Newcomer, M.E.
登録日2011-12-23
公開日2012-05-02
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.
Faseb J., 26, 2012
3O8Y
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BU of 3o8y by Molmil
Stable-5-Lipoxygenase
分子名称: Arachidonate 5-lipoxygenase, FE (II) ION
著者Newcomer, M.E, Gilbert, N.C, Bartlett, S.G, Waight, M.T, Neau, D.B, Boeglin, W.E, Brash, A.R.
登録日2010-08-03
公開日2011-01-19
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.389 Å)
主引用文献The structure of human 5-lipoxygenase.
Science, 331, 2011
3QVL
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BU of 3qvl by Molmil
Allantoin racemase from Klebsiella pneumoniae
分子名称: Putative hydantoin racemase, [(4R)-2,5-dioxoimidazolidin-4-yl]acetic acid
著者French, J.B, Neau, D.B, Ealick, S.E.
登録日2011-02-25
公開日2011-05-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.822 Å)
主引用文献Characterization of the Structure and Function of Klebsiella pneumoniae Allantoin Racemase.
J.Mol.Biol., 410, 2011
3QVJ
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Allantoin racemase from Klebsiella pneumoniae
分子名称: CHLORIDE ION, Putative hydantoin racemase
著者French, J.B, Neau, D.B, Ealick, S.E.
登録日2011-02-25
公開日2011-05-04
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Characterization of the Structure and Function of Klebsiella pneumoniae Allantoin Racemase.
J.Mol.Biol., 410, 2011
3QVK
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BU of 3qvk by Molmil
Allantoin racemase from Klebsiella pneumoniae
分子名称: 1-(2,5-DIOXO-2,5-DIHYDRO-1H-IMIDAZOL-4-YL)UREA, Putative hydantoin racemase
著者French, J.B, Neau, D.B, Ealick, S.E.
登録日2011-02-25
公開日2011-05-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Characterization of the Structure and Function of Klebsiella pneumoniae Allantoin Racemase.
J.Mol.Biol., 410, 2011
6NCF
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BU of 6ncf by Molmil
The structure of Stable-5-Lipoxygenase bound to AKBA
分子名称: (3alpha,8alpha,17alpha,18alpha)-3-(acetyloxy)-11-oxours-12-en-23-oic acid, Arachidonate 5-lipoxygenase, FE (II) ION
著者Newcomer, M.E, Gilbert, N.C, Neau, D.B.
登録日2018-12-11
公開日2020-05-13
最終更新日2020-07-08
実験手法X-RAY DIFFRACTION (2.871 Å)
主引用文献Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products.
Nat.Chem.Biol., 16, 2020
6NS6
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BU of 6ns6 by Molmil
Crystal structure of fungal lipoxygenase from Fusarium graminearum. P21 crystal form.
分子名称: FE (II) ION, lipoxygenase
著者Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E.
登録日2019-01-24
公開日2019-03-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere.
Protein Sci., 28, 2019
6NS5
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Crystal structure of fungal lipoxygenase from Fusarium graminearum. Second C2 crystal form.
分子名称: FE (II) ION, lipoxygenase
著者Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E.
登録日2019-01-24
公開日2019-03-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere.
Protein Sci., 28, 2019

 

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