4RBQ
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![BU of 4rbq by Molmil](/molmil-images/mine/4rbq) | 32 base pair oligo(U) RNA | Descriptor: | POTASSIUM ION, U-Helix RNA from Trypanosome editing | Authors: | Mooers, B.H.M. | Deposit date: | 2014-09-12 | Release date: | 2015-11-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Structure of the Trypanosome RNA Editing U-Helix with 16 Contiguous Us To be Published
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253D
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340D
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343D
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345D
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341D
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342D
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346D
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337D
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338D
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339D
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8G2K
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7JU6
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![BU of 7ju6 by Molmil](/molmil-images/mine/7ju6) | Structure of RET protein tyrosine kinase in complex with selpercatinib | Descriptor: | FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret, Selpercatinib | Authors: | Terzyan, S.S, Shen, T, Wu, J, Mooers, B.H.M. | Deposit date: | 2020-08-19 | Release date: | 2020-11-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations. Ann Oncol, 32, 2021
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7JU5
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![BU of 7ju5 by Molmil](/molmil-images/mine/7ju5) | Structure of RET protein tyrosine kinase in complex with pralsetinib | Descriptor: | FORMIC ACID, Pralsetinib, Proto-oncogene tyrosine-protein kinase receptor Ret | Authors: | Terzyan, S.S, Shen, T, Wu, J, Mooers, B.H.M. | Deposit date: | 2020-08-19 | Release date: | 2020-11-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations. Ann Oncol, 32, 2021
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6NE7
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![BU of 6ne7 by Molmil](/molmil-images/mine/6ne7) | Structure of G810A mutant of RET protein tyrosine kinase domain. | Descriptor: | ADENOSINE MONOPHOSPHATE, FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret | Authors: | Terzyan, S.S, Shen, T, Wu, J, Mooers, B.H.M. | Deposit date: | 2018-12-17 | Release date: | 2019-06-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J.Biol.Chem., 294, 2019
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6NEC
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![BU of 6nec by Molmil](/molmil-images/mine/6nec) | STRUCTURE OF RET PROTEIN TYROSINE KINASE DOMAIN IN COMPLEX WITH NINTEDANIB | Descriptor: | FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret, methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate | Authors: | Terzyan, S.S, Shen, T, Wu, J, Mooers, B.H.M. | Deposit date: | 2018-12-17 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J.Biol.Chem., 294, 2019
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6NJA
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![BU of 6nja by Molmil](/molmil-images/mine/6nja) | Structure of WT RET protein tyrosine kinase domain at 1.92A resolution. | Descriptor: | ADENINE, FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret | Authors: | Terzyan, S.S, Shen, T, Wu, J, Mooers, B.H.M. | Deposit date: | 2019-01-02 | Release date: | 2019-06-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J.Biol.Chem., 294, 2019
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1FHZ
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![BU of 1fhz by Molmil](/molmil-images/mine/1fhz) | PSORALEN CROSS-LINKED D(CCGGTACCGG) FORMS HOLLIDAY JUNCTION | Descriptor: | 4'-HYDROXYMETHYL-4,5',8-TRIMETHYLPSORALEN, DNA (5'-D(*CP*CP*GP*GP*TP*AP*CP*CP*GP*G)-3') | Authors: | Eichman, B.F, Mooers, B.H.M, Alberti, M, Hearst, J.E, Ho, P.S. | Deposit date: | 2000-08-02 | Release date: | 2001-04-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structures of psoralen cross-linked DNAs: drug-dependent formation of Holliday junctions. J.Mol.Biol., 308, 2001
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1FHY
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![BU of 1fhy by Molmil](/molmil-images/mine/1fhy) | PSORALEN CROSS-LINKED D(CCGCTAGCGG) FORMS HOLLIDAY JUNCTION | Descriptor: | 4'-HYDROXYMETHYL-4,5',8-TRIMETHYLPSORALEN, CALCIUM ION, DNA (5'-D(*CP*CP*GP*CP*TP*AP*GP*CP*GP*G)-3') | Authors: | Eichman, B.F, Mooers, B.H.M, Alberti, M, Hearst, J.E, Ho, P.S. | Deposit date: | 2000-08-02 | Release date: | 2001-04-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structures of psoralen cross-linked DNAs: drug-dependent formation of Holliday junctions. J.Mol.Biol., 308, 2001
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5DA6
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4PCO
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5D99
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![BU of 5d99 by Molmil](/molmil-images/mine/5d99) | 3DW4 redetermined by direct methods starting from random phase angles | Descriptor: | GLYCEROL, RNA (27-MER) hairpin from sarcin-ricin domain of E. coli 23S rRNA | Authors: | Mooers, B.H.M. | Deposit date: | 2015-08-18 | Release date: | 2016-04-13 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (0.97 Å) | Cite: | Direct-methods structure determination of a trypanosome RNA-editing substrate fragment with translational pseudosymmetry. Acta Crystallogr D Struct Biol, 72, 2016
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3F8V
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3FA0
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3FAD
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