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SARS-CoV-2 S2 helix epitope scaffold
Descriptor:	S2hlx_EX_19
Authors:	Kapingidza, A.B, Wrapp, D, Winters, K, Azoitei, M.L.
Deposit date:	2022-11-14
Release date:	2023-10-11
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Engineered immunogens to elicit antibodies against conserved coronavirus epitopes. Nat Commun, 14, 2023

8FDO

SARS-CoV-2 fusion peptide epitope scaffold FP15 bound to DH1058
Descriptor:	DH1058 Heavy chain, DH1058 Light chain, FP15
Authors:	Kapingidza, A.B, Marston, D.J, Wrapp, D, Winters, K, Azoitei, M.L.
Deposit date:	2022-12-04
Release date:	2023-10-11
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Engineered immunogens to elicit antibodies against conserved coronavirus epitopes. Nat Commun, 14, 2023

8F5I

SARS-CoV-2 S2 helix epitope scaffold bound by antibody DH1057.1
Descriptor:	DH1057.1 HC, DH1057.1 LC, Specialized acyl carrier protein, ...
Authors:	Kapingidza, A.B, Wrapp, D, Winters, K, Azoitei, M.L.
Deposit date:	2022-11-14
Release date:	2023-10-11
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Engineered immunogens to elicit antibodies against conserved coronavirus epitopes. Nat Commun, 14, 2023

4HQQ

Crystal structure of RV144-elicited antibody CH58
Descriptor:	CH58 Fab heavy chain, CH58 Fab light chain
Authors:	McLellan, J.S, Haynes, B.F, Kwong, P.D.
Deposit date:	2012-10-25
Release date:	2013-02-06
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2. Immunity, 38, 2013

4HPY

Crystal structure of RV144-elicited antibody CH59 in complex with V2 peptide
Descriptor:	CH59 Fab heavy chain, CH59 Fab light chain, Envelope glycoprotein gp160, ...
Authors:	McLellan, J.S, Gorman, J, Haynes, B.F, Kwong, P.D.
Deposit date:	2012-10-24
Release date:	2013-02-06
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2. Immunity, 38, 2013

4HPO

Crystal structure of RV144-elicited antibody CH58 in complex with V2 peptide
Descriptor:	CH58 Fab heavy chain, CH58 Fab light chain, Envelope glycoprotein gp160, ...
Authors:	McLellan, J.S, Gorman, J, Haynes, B.F, Kwong, P.D.
Deposit date:	2012-10-24
Release date:	2013-02-06
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.694 Å)
Cite:	Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2. Immunity, 38, 2013

6ORN

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch bNAb 10-1074
Descriptor:	10-1074 antibody Fab heavy chain, 10-1074 antibody Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Abernathy, M.E, Gristick, H.B, Bjorkman, P.J.
Deposit date:	2019-04-30
Release date:	2019-06-12
Last modified:	2020-07-29
Method:	ELECTRON MICROSCOPY (4.05 Å)
Cite:	Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019

6ORO

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab874NHP
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab874NHP antibody Fab heavy chain, ...
Authors:	Abernathy, M.E, Gristick, H.B, Bjorkman, P.J.
Deposit date:	2019-04-30
Release date:	2019-06-12
Last modified:	2020-07-29
Method:	ELECTRON MICROSCOPY (3.9 Å)
Cite:	Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019

6ORQ

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab275MUR
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab275MUR antibody Fab heavy chain, ...
Authors:	Abernathy, M.E, Gristick, H.B, Bjorkman, P.J.
Deposit date:	2019-04-30
Release date:	2019-06-12
Last modified:	2020-07-29
Method:	ELECTRON MICROSCOPY (4.4 Å)
Cite:	Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019

6ORP

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab897NHP
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab897NHP antibody Fab heavy chain, ...
Authors:	Abernathy, M.E, Gristick, H.B, Bjorkman, P.J.
Deposit date:	2019-04-30
Release date:	2019-06-12
Last modified:	2020-07-29
Method:	ELECTRON MICROSCOPY (4.4 Å)
Cite:	Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019

6P3B

Crystal structure of the anti-HIV antibody DH501 unmutated common ancestor (UCA)
Descriptor:	1,2-ETHANEDIOL, DH501UCA Fab Heavy chain, DH501UCA Fab Light chain
Authors:	Nicely, N.I, Saunders, K.O.
Deposit date:	2019-05-23
Release date:	2019-11-20
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.02 Å)
Cite:	Cooperation between somatic mutation and germline-encoded residues enable antibody recognition of HIV-1 envelope glycans. Plos Pathog., 15, 2019

6P8N

Crystal Structure of Antibody P-p1f1 in Complex with eOD-GT8
Descriptor:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, AMMONIUM ION, ...
Authors:	Weidle, C, Pancera, M.
Deposit date:	2019-06-07
Release date:	2019-11-20
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (3.202 Å)
Cite:	Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization. Cell Rep, 29, 2019

6P6F

BG505 SOSIP-I53-50NP
Descriptor:	I53-50A.1NT1, I53-50B.4PT1
Authors:	Berndsen, Z.T, Ward, A.B.
Deposit date:	2019-06-03
Release date:	2019-06-19
Last modified:	2019-12-18
Method:	ELECTRON MICROSCOPY (4.5 Å)
Cite:	Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle. Nat Commun, 10, 2019

6P8M

Crystal Structure of Antibody P-p3b3 A60C Heavy Chain in Complex with 426c HIV-1 gp120 core G459C
Descriptor:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, AMMONIUM ION, ...
Authors:	Weidle, C, Pancera, M.
Deposit date:	2019-06-07
Release date:	2019-11-20
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (3.594 Å)
Cite:	Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization. Cell Rep, 29, 2019

6VBQ

Crystal structure of anti-HIV-1 antibody DH822 bound to gp120 V2 peptide
Descriptor:	DH822 heavy chain, DH822 light chain, Envelope glycoprotein gp160
Authors:	Janus, B.M, Ofek, G.
Deposit date:	2019-12-19
Release date:	2020-02-12
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.116 Å)
Cite:	HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions. JCI Insight, 5, 2020

6VBO

Crystal structure of anti-HIV-1 antibody DH813 bound to gp120 V2 peptide
Descriptor:	DH813 heavy chain, DH813 light chain, Envelope glycoprotein gp160
Authors:	Janus, B.M, Ofek, G.
Deposit date:	2019-12-19
Release date:	2020-02-12
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.683 Å)
Cite:	HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions. JCI Insight, 5, 2020

6VTU

DH717.1 Fab monomer in complex with man9 glycan
Descriptor:	DH717.1 heavy chain, DH717.1 light chain, GLYCEROL, ...
Authors:	Fera, D, Bronkema, N.
Deposit date:	2020-02-13
Release date:	2020-12-30
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.61 Å)
Cite:	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021

6VO3

AMC009 SOSIP.v4.2 in complex with PGV04 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMC009 SOSIP.v4.2 envelope glycoprotein gp120, ...
Authors:	Cottrell, C.A, de Val, N, Ward, A.B.
Deposit date:	2020-01-29
Release date:	2020-09-23
Last modified:	2020-12-09
Method:	ELECTRON MICROSCOPY (4.25 Å)
Cite:	Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers. J.Virol., 94, 2020

6XRJ

Crystal structure of the disulfide linked DH717.1 Fab dimer, derived from a macaque HIV-1 vaccine-induced Env glycan-reactive neutralizing antibody B cell lineage
Descriptor:	DH717.1 heavy chain Fab fragment, DH717.1 light chain Fab fragment
Authors:	Manne, K, Nicely, N.I, Acharya, P.
Deposit date:	2020-07-13
Release date:	2020-12-30
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (3.15 Å)
Cite:	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021

5DD6

Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques
Descriptor:	ANTI-HIV ANTIBODY DH570.mut58 FAB HEAVY CHAIN, ANTI-HIV ANTIBODY DH570.mut58 FAB LIGHT CHAIN
Authors:	Nicely, N.I, Pemble IV, C.W, Haynes, B.F.
Deposit date:	2015-08-24
Release date:	2016-05-11
Last modified:	2019-12-11
Method:	X-RAY DIFFRACTION (1.699 Å)
Cite:	Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. Sci Transl Med, 8, 2016

5DD3

Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques
Descriptor:	ANTI-HIV ANTIBODY DH570.4 FAB HEAVY CHAIN, ANTI-HIV ANTIBODY DH570.4 FAB LIGHT CHAIN
Authors:	Nicely, N.I, Pemble IV, C.W, Haynes, B.F.
Deposit date:	2015-08-24
Release date:	2016-05-11
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.797 Å)
Cite:	Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. Sci Transl Med, 8, 2016

5DD5

Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques
Descriptor:	ANTI-HIV ANTIBODY DH570.9 FAB HEAVY CHAIN
Authors:	Nicely, N.I, Pemble IV, C.W, Haynes, B.F.
Deposit date:	2015-08-24
Release date:	2016-05-11
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. Sci Transl Med, 8, 2016

5F6I

Crystal Structure of Tier 2 Neutralizing Antibody DH428 from a Rhesus Macaque
Descriptor:	DH428 Antibody Heavy Chain, DH428 Antibody Light Chain
Authors:	Fera, D, Harrison, S.C.
Deposit date:	2015-12-06
Release date:	2016-01-13
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.32 Å)
Cite:	Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site. Cell Rep, 14, 2016

5F6H

Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque
Descriptor:	DH427 Antibody Heavy Chain, DH427 Antibody Light Chain
Authors:	Fera, D, Harrison, S.C.
Deposit date:	2015-12-06
Release date:	2016-01-13
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.66 Å)
Cite:	Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site. Cell Rep, 14, 2016

5F6J

Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque in Complex with HIV-1 gp120 Core
Descriptor:	DH427 Antibody Heavy Chain, DH427 Antibody Light Chain, ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C
Authors:	Fera, D, Harrison, S.C.
Deposit date:	2015-12-06
Release date:	2016-01-13
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (6.63 Å)
Cite:	Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site. Cell Rep, 14, 2016

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