1NEK
| Complex II (Succinate Dehydrogenase) From E. Coli with ubiquinone bound | Descriptor: | CALCIUM ION, CARDIOLIPIN, FE2/S2 (INORGANIC) CLUSTER, ... | Authors: | Yankovskaya, V, Horsefield, R, Tornroth, S, Luna-Chavez, C, Miyoshi, H, Leger, C, Byrne, B, Cecchini, G, Iwata, S. | Deposit date: | 2002-12-11 | Release date: | 2003-02-25 | Last modified: | 2024-11-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Architecture of succinate dehydrogenase and
reactive oxygen species generation. Science, 299, 2003
|
|
1NEN
| Complex II (Succinate Dehydrogenase) From E. Coli with Dinitrophenol-17 inhibitor co-crystallized at the ubiquinone binding site | Descriptor: | 2-[1-METHYLHEXYL]-4,6-DINITROPHENOL, CALCIUM ION, CARDIOLIPIN, ... | Authors: | Yankovskaya, V, Horsefield, R, Tornroth, S, Luna-Chavez, C, Miyoshi, H, Leger, C, Byrne, B, Cecchini, G, Iwata, S. | Deposit date: | 2002-12-11 | Release date: | 2003-02-25 | Last modified: | 2024-11-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Architecture of succinate dehydrogenase and
reactive oxygen species generation Science, 299, 2003
|
|
1IPB
| CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E COMPLEXED WITH 7-METHYL GPPPA | Descriptor: | EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE | Authors: | Tomoo, K, Shen, X, Okabe, K, Nozoe, Y, Fukuhara, S, Morino, S, Ishida, T, Taniguchi, T, Hasegawa, H, Terashima, A, Sasaki, M, Katsuya, Y, Kitamura, K, Miyoshi, H, Ishikawa, M, Miura, K. | Deposit date: | 2001-05-08 | Release date: | 2002-05-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and
P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic
initiation factor 4E: biological importance of the C-terminal flexible region BIOCHEM.J., 362, 2002
|
|
1IPC
| CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E COMPLEXED WITH 7-METHYL GTP | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E | Authors: | Tomoo, K, Shen, X, Okabe, K, Nozoe, Y, Fukuhara, S, Morino, S, Ishida, T, Taniguchi, T, Hasegawa, H, Terashima, A, Sasaki, M, Katsuya, Y, Kitamura, K, Miyoshi, H, Ishikawa, M, Miura, K. | Deposit date: | 2001-05-08 | Release date: | 2002-05-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and
P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic
initiation factor 4E: biological importance of the C-terminal flexible region BIOCHEM.J., 362, 2002
|
|
7XK7
| Cryo-EM structure of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae, with korormicin | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Kishikawa, J, Ishikawa, M, Masuya, T, Murai, M, Barquera, B, Miyoshi, H. | Deposit date: | 2022-04-19 | Release date: | 2022-07-20 | Last modified: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Cryo-EM structures of Na + -pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae. Nat Commun, 13, 2022
|
|
7XK4
| Cryo-EM structure of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae, state 2 | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Kishikawa, J, Ishikawa, M, Masuya, T, Murai, M, Barquera, B, Miyoshi, H. | Deposit date: | 2022-04-19 | Release date: | 2022-07-20 | Last modified: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structures of Na + -pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae. Nat Commun, 13, 2022
|
|
7XK5
| Cryo-EM structure of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae, state 3 | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Kishikawa, J, Ishikawa, M, Masuya, T, Murai, M, Barquera, B, Miyoshi, H. | Deposit date: | 2022-04-19 | Release date: | 2022-07-20 | Last modified: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structures of Na + -pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae. Nat Commun, 13, 2022
|
|
7XK3
| Cryo-EM structure of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae, state 1 | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Kishikawa, J, Ishikawa, M, Masuya, T, Murai, M, Barquera, B, Miyoshi, H. | Deposit date: | 2022-04-19 | Release date: | 2022-07-20 | Last modified: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structures of Na + -pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae. Nat Commun, 13, 2022
|
|
7XK6
| Cryo-EM structure of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae, with aurachin D-42 | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Aurachin D, CALCIUM ION, ... | Authors: | Kishikawa, J, Ishikawa, M, Masuya, T, Murai, M, Barquera, B, Miyoshi, H. | Deposit date: | 2022-04-19 | Release date: | 2022-07-20 | Last modified: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM structures of Na + -pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae. Nat Commun, 13, 2022
|
|
5YJX
| Structure of the Ndi1 protein from Saccharomyces cerevisiae in complex with myxothiazol. | Descriptor: | (2Z,6E)-7-{2'-[(2E,4E)-1,6-DIMETHYLHEPTA-2,4-DIENYL]-2,4'-BI-1,3-THIAZOL-4-YL}-3,5-DIMETHOXY-4-METHYLHEPTA-2,6-DIENAMID E, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Yamasita, T, Inaoka, D.K, Shiba, T, Oohashi, T, Iwata, S, Yagi, T, Kosaka, H, Harada, S, Kita, K, Hirano, K. | Deposit date: | 2017-10-11 | Release date: | 2018-02-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors Sci Rep, 8, 2018
|
|
6RKO
| Cryo-EM structure of the E. coli cytochrome bd-I oxidase at 2.68 A resolution | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CIS-HEME D HYDROXYCHLORIN GAMMA-SPIROLACTONE, Cytochrome bd-I ubiquinol oxidase subunit 1, ... | Authors: | Safarian, S, Hahn, A, Kuehlbrandt, W, Michel, H. | Deposit date: | 2019-04-30 | Release date: | 2019-10-16 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | Active site rearrangement and structural divergence in prokaryotic respiratory oxidases. Science, 366, 2019
|
|
7PSA
| The acetogenin-bound complex I of Mus musculus resolved to 3.4 angstroms | Descriptor: | (3~{S},5~{S})-5-methyl-3-[(13~{R})-13-oxidanyl-13-[(2~{R},5~{R})-5-[(2~{R},5~{R})-5-[(1~{R})-1-oxidanylundecyl]oxolan-2-yl]oxolan-2-yl]tridecyl]oxolan-2-one, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | Authors: | Grba, D, Hirst, J. | Deposit date: | 2021-09-22 | Release date: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I. J.Biol.Chem., 298, 2022
|
|
6K9U
| Discovery of Pyrazolo[1,5-a]pyrimidine Derivative as a Highly Selective PDE10A Inhibitor | Descriptor: | 2-(3,7-dimethylquinoxalin-2-yl)-~{N}-(oxan-4-yl)-5-pyrrolidin-1-yl-pyrazolo[1,5-a]pyrimidin-7-amine, MAGNESIUM ION, SULFATE ION, ... | Authors: | Takedomi, K, Koizumi, Y. | Deposit date: | 2019-06-18 | Release date: | 2019-07-17 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety. Bioorg.Med.Chem., 27, 2019
|
|
5YJY
| Structure of the Ndi1 protein from Saccharomyces cerevisiae in complex with AC0-12. | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-dodecyl-1-oxidanidyl-quinolin-1-ium-4-ol, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Yamasita, T, Inaoka, D.K, Shiba, T, Oohashi, T, Iwata, S, Yagi, T, Kosaka, H, Harada, S, Kita, K, Hirano, K. | Deposit date: | 2017-10-11 | Release date: | 2018-02-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors Sci Rep, 8, 2018
|
|
5YJW
| Structure of the Ndi1 protein from Saccharomyces cerevisiae in complex with the competitive inhibitor, stigmatellin. | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, DI(HYDROXYETHYL)ETHER, ... | Authors: | Yamasita, T, Inaoka, D.K, Shiba, T, Oohashi, T, Iwata, S, Yagi, T, Kosaka, H, Harada, S, Kita, K, Hirano, K. | Deposit date: | 2017-10-11 | Release date: | 2018-02-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors Sci Rep, 8, 2018
|
|
6NU4
| Solution structure of the Arabidopsis thaliana RALF8 peptide | Descriptor: | Protein RALF-like 8 | Authors: | Lee, W, Markley, J.L, Frederick, R.O, Miyoshi, H, Tonelli, M, Cornilescu, G, Cornilescu, C, Sussman, M.R. | Deposit date: | 2019-01-30 | Release date: | 2019-05-08 | Last modified: | 2024-11-06 | Method: | SOLUTION NMR | Cite: | Function and solution structure of the Arabidopsis thaliana RALF8 peptide. Protein Sci., 28, 2019
|
|
7N4N
| BACE-2 in complex with ligand 36 | Descriptor: | 1,2-ETHANEDIOL, Beta-secretase 2, N-{3-[(2S,5R)-6-amino-2-(fluoromethyl)-5-(methanesulfonyl)-5-methyl-2,3,4,5-tetrahydropyridin-2-yl]-4-fluorophenyl}-6-methoxypyrimidine-4-carboxamide, ... | Authors: | Shaffer, P.L. | Deposit date: | 2021-06-04 | Release date: | 2021-10-06 | Last modified: | 2024-11-20 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate. J.Med.Chem., 64, 2021
|
|
7N66
| BACE-1 in complex with ligand 12 | Descriptor: | Beta-secretase 1, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Shaffer, P.L. | Deposit date: | 2021-06-07 | Release date: | 2021-10-06 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate. J.Med.Chem., 64, 2021
|
|