1IJD
| Crystallographic Structure of the LH3 Complex from Rhodopseudomonas acidophila strain 7050 | 分子名称: | BACTERIOCHLOROPHYLL A, LIGHT-HARVESTING PROTEIN B-800/820, ALPHA CHAIN, ... | 著者 | McLuskey, K, Prince, S.M, Cogdell, R.J, Isaacs, N.W. | 登録日 | 2001-04-25 | 公開日 | 2001-10-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The crystallographic structure of the B800-820 LH3 light-harvesting complex from the purple bacteria Rhodopseudomonas acidophila strain 7050. Biochemistry, 40, 2001
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1NP6
| Crystal structure of Escherichia coli MobB | 分子名称: | Molybdopterin-guanine dinucleotide biosynthesis protein B, SULFATE ION | 著者 | McLuskey, K, Harrison, J.A, Schuttelkopf, A.W, Boxer, D.H, Hunter, W.N. | 登録日 | 2003-01-17 | 公開日 | 2003-04-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Insight into the role of Escherichia coli MobB in Molybdenum cofactor biosynthesis based on the high resolution crystal structure J.Biol.Chem., 278, 2003
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2BNN
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2BNO
| The structure of Hydroxypropylphosphonic acid epoxidase from S. wedmorenis. | 分子名称: | EPOXIDASE, MERCURY (II) ION, SULFATE ION, ... | 著者 | McLuskey, K, Cameron, S, Hunter, W.N. | 登録日 | 2005-03-29 | 公開日 | 2005-10-05 | 最終更新日 | 2017-06-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure and Reactivity of Hydroxypropylphosphonic Acid Epoxidase in Fosfomycin Biosynthesis by a Cation- and Flavin-Dependent Mechanism. Proc.Natl.Acad.Sci.USA, 102, 2005
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2BNM
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1W0C
| Inhibition of Leishmania major pteridine reductase (PTR1) by 2,4,6-triaminoquinazoline; structure of the NADP ternary complex. | 分子名称: | 2,4,6-TRIAMINOQUINAZOLINE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PTERIDINE REDUCTASE | 著者 | Mcluskey, K, Gibellini, F, Carvalho, P, Avery, M, Hunter, W. | 登録日 | 2004-06-02 | 公開日 | 2004-09-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Inhibition of Leishmania Major Pteridine Reductase by 2,4,6-Triaminoquinazoline: Structure of the Nadph Ternary Complex Acta Crystallogr.,Sect.D, 60, 2004
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4AF8
| The structural basis for metacaspase substrate specificity and activation | 分子名称: | CHLORIDE ION, METACASPASE MCA2, SODIUM ION | 著者 | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | 登録日 | 2012-01-18 | 公開日 | 2012-05-02 | 最終更新日 | 2017-07-05 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Crystal Structure of a Trypanosoma Brucei Metacaspase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4AFR
| THE STRUCTURE OF METACASPASE 2 (C213A MUTANT) FROM T. BRUCEI | 分子名称: | METACASPASE | 著者 | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | 登録日 | 2012-01-23 | 公開日 | 2012-05-02 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal Structure of a Trypanosoma Brucei Metacaspase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4AFV
| THE STRUCTURE OF METACASPASE 2 FROM T. BRUCEI DETERMINED IN THE PRESENCE OF CALCIUM CHLORIDE | 分子名称: | METACASPASE MCA2 | 著者 | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | 登録日 | 2012-01-23 | 公開日 | 2012-05-02 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal Structure of a Trypanosoma Brucei Metacaspase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4AFP
| The structure of metacaspase 2 from T. brucei determined in the presence of Samarium | 分子名称: | METACASPASE MCA2, SAMARIUM (III) ION | 著者 | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | 登録日 | 2012-01-23 | 公開日 | 2012-05-02 | 最終更新日 | 2017-07-05 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structure of a Trypanosoma Brucei Metacaspase. Proc.Natl.Acad.Sci.USA, 109, 2012
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2XE4
| Structure of Oligopeptidase B from Leishmania major | 分子名称: | ANTIPAIN, CHLORIDE ION, GLYCEROL, ... | 著者 | McLuskey, K, Paterson, N.G, Bland, N.D, Mottram, J.C, Isaacs, N.W. | 登録日 | 2010-05-11 | 公開日 | 2010-10-06 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal Structure of Leishmania Major Oligopeptidase B Gives Insight Into the Enzymatic Properties of a Trypanosomatid Virulence Factor. J.Biol.Chem., 285, 2010
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3H4V
| Selective screening and design to identify inhibitors of leishmania major pteridine reductase 1 | 分子名称: | METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL]AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pteridine reductase 1 | 著者 | Mcluskey, K, Gibellini, F, Hunter, W.N. | 登録日 | 2009-04-21 | 公開日 | 2009-05-05 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development Proc.Natl.Acad.Sci.USA, 105, 2008
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2QHX
| Structure of Pteridine Reductase from Leishmania major complexed with a ligand | 分子名称: | IODIDE ION, METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL](METHYL)AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Gibellini, F, Mcluskey, K, Tulloch, L, Hunter, W.N. | 登録日 | 2007-07-03 | 公開日 | 2007-12-25 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development. Proc.Natl.Acad.Sci.USA, 105, 2008
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2C7V
| Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate | 分子名称: | ACETATE ION, METHOTREXATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Dawson, A, Gibellini, F, Sienkiewicz, N, Fyfe, P.K, McLuskey, K, Fairlamb, A.H, Hunter, W.N. | 登録日 | 2005-11-29 | 公開日 | 2006-09-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition by the Archetypal Antifolate Methotrexate Mol.Microbiol., 61, 2006
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4NKR
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3UWS
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1UV7
| periplasmic domain of EpsM from Vibrio cholerae | 分子名称: | GENERAL SECRETION PATHWAY PROTEIN M | 著者 | Abendroth, J, Hol, W.G.J. | 登録日 | 2004-01-15 | 公開日 | 2004-04-23 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Crystal Structure of the Periplasmic Domain of the Type II Secretion System Protein Epsm from Vibrio Cholerae: The Simplest Version of the Ferredoxin Fold J.Mol.Biol., 338, 2004
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2VZ0
| Pteridine Reductase 1 (PTR1) from Trypanosoma Brucei in complex with NADP and DDD00066641 | 分子名称: | 6-(4-methylphenyl)quinazoline-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PTERIDINE REDUCTASE | 著者 | Robinson, D.A, Thompson, S, Sienkiewicz, N, Fairlamb, A.H. | 登録日 | 2008-07-29 | 公開日 | 2009-09-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Development and Validation of a Cytochrome C Coupled Assay for Pteridine Reductase 1 and Dihydrofolate Reductase. Anal.Biochem., 396, 2010
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2WD8
| PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00071204 | 分子名称: | 1-(3,4-DICHLOROBENZYL)-7-PHENYL-1H-BENZIMIDAZOL-2-AMINE, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Robinson, D.A, Wyatt, P.G, Spinks, D, Brenk, R. | 登録日 | 2009-03-20 | 公開日 | 2009-06-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening. J.Med.Chem., 52, 2009
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