4KWH
 
 | | The crystal structure of angucycline C-6 ketoreductase LanV with bound NADP | | 分子名称: | ACETIC ACID, DI(HYDROXYETHYL)ETHER, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Paananen, P, Patrikainen, P, Kallio, P, Mantsala, P, Niemi, J, Niiranen, L, Metsa-Ketela, M. | | 登録日 | 2013-05-24 | | 公開日 | 2013-07-31 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis.
Biochemistry, 52, 2013
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4KWI
 | | The crystal structure of angucycline C-6 ketoreductase LanV with bound NADP and 11-deoxy-6-oxylandomycinone | | 分子名称: | 1,8-dihydroxy-3-methyltetraphene-6,7,12(5H)-trione, DI(HYDROXYETHYL)ETHER, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Paananen, P, Patrikainen, P, Mantsala, P, Niemi, J, Niiranen, L, Metsa-Ketela, M. | | 登録日 | 2013-05-24 | | 公開日 | 2013-07-31 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis.
Biochemistry, 52, 2013
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4ICY
 | | Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Kallio, P, Patrikainen, P, Belogurov, G, Mantsala, P, Yang, K, Niemi, J, Metsa-Ketela, M. | | 登録日 | 2012-12-11 | | 公開日 | 2013-06-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE.
Biochemistry, 52, 2013
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1Q0Z
 | | Crystal structure of aclacinomycin methylesterase (RdmC) with bound product analogue, 10-decarboxymethylaclacinomycin A (DcmA) | | 分子名称: | 10-DECARBOXYMETHYLACLACINOMYCIN A (DCMAA), PENTAETHYLENE GLYCOL, SULFATE ION, ... | | 著者 | Jansson, A, Niemi, J, Mantsala, P, Schneider, G, Structural Proteomics in Europe (SPINE) | | 登録日 | 2003-07-18 | | 公開日 | 2003-11-25 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.
J.Biol.Chem., 278, 2003
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1Q0R
 | | Crystal structure of aclacinomycin methylesterase (RdmC) with bound product analogue, 10-decarboxymethylaclacinomycin T (DcmaT) | | 分子名称: | 10-DECARBOXYMETHYLACLACINOMYCIN T (DCMAT), PENTAETHYLENE GLYCOL, SULFATE ION, ... | | 著者 | Jansson, A, Niemi, J, Mantsala, P, Schneider, G, Structural Proteomics in Europe (SPINE) | | 登録日 | 2003-07-17 | | 公開日 | 2003-11-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.
J.Biol.Chem., 278, 2003
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1QZZ
 | | Crystal structure of aclacinomycin-10-hydroxylase (RdmB) in complex with S-adenosyl-L-methionine (SAM) | | 分子名称: | ACETATE ION, S-ADENOSYLMETHIONINE, aclacinomycin-10-hydroxylase | | 著者 | Jansson, A, Niemi, J, Lindqvist, Y, Mantsala, P, Schneider, G, Structural Proteomics in Europe (SPINE) | | 登録日 | 2003-09-19 | | 公開日 | 2003-11-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure of Aclacinomycin-10-Hydroxylase, a S-Adenosyl-L-Methionine-dependent Methyltransferase Homolog Involved in Anthracycline Biosynthesis in Streptomyces purpurascens.
J.Mol.Biol., 334, 2003
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1R00
 | | Crystal structure of aclacinomycin-10-hydroxylase (RdmB) in complex with S-adenosyl-L-homocysteine (SAH) | | 分子名称: | ACETATE ION, S-ADENOSYL-L-HOMOCYSTEINE, aclacinomycin-10-hydroxylase | | 著者 | Jansson, A, Niemi, J, Lindqvist, Y, Mantsala, P, Schneider, G. | | 登録日 | 2003-09-19 | | 公開日 | 2003-11-25 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of Aclacinomycin-10-Hydroxylase, a S-Adenosyl-L-Methionine-dependent Methyltransferase Homolog Involved in Anthracycline Biosynthesis in Streptomyces purpurascens.
J.Mol.Biol., 334, 2003
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3KG1
 | | Crystal structure of SnoaB, a cofactor-independent oxygenase from Streptomyces nogalater, mutant N63A | | 分子名称: | CHLORIDE ION, SnoaB | | 著者 | Koskiniemi, H, Grocholski, T, Lindqvist, Y, Mantsala, P, Niemi, J, Schneider, G. | | 登録日 | 2009-10-28 | | 公開日 | 2010-01-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism
Biochemistry, 49, 2010
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3KG0
 | | Crystal structure of SnoaB, a cofactor-independent oxygenase from Streptomyces nogalater, determined to 1.7 resolution | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, SnoaB | | 著者 | Koskiniemi, H, Grocholski, T, Lindqvist, Y, Mantsala, P, Niemi, J, Schneider, G. | | 登録日 | 2009-10-28 | | 公開日 | 2010-01-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism
Biochemistry, 49, 2010
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3KNG
 | | Crystal structure of SnoaB, a cofactor-independent oxygenase from Streptomyces nogalater, determined to 1.9 resolution | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ... | | 著者 | Koskiniemi, H, Grocholski, T, Lindqvist, Y, Mantsala, P, Niemi, J, Schneider, G. | | 登録日 | 2009-11-12 | | 公開日 | 2010-01-26 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism
Biochemistry, 49, 2010
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1TW3
 | | Crystal structure of Carminomycin-4-O-methyltransferase (DnrK) in complex with S-adenosyl-L-homocystein (SAH) and 4-methoxy-e-rhodomycin T (M-ET) | | 分子名称: | Carminomycin 4-O-methyltransferase, METHYL (4R)-2-ETHYL-2,5,12-TRIHYDROXY-7-METHOXY-6,11-DIOXO-4-{[2,3,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-RIBO-HEXOPYRANOSYL]OXY}-1H,2H,3H,4H,6H,11H-TETRACENE-1-CARBOXYLATE, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Jansson, A, Koskiniemi, H, Mantsala, P, Niemi, J, Schneider, G. | | 登録日 | 2004-06-30 | | 公開日 | 2004-09-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products
J.Biol.Chem., 279, 2004
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1QD9
 | | Bacillus subtilis YABJ | | 分子名称: | ACETIC ACID, ETHYL MERCURY ION, MERCURY (II) ION, ... | | 著者 | Smith, J.L, Sinha, S, Rappu, P, Lange, S.C, Mantsala, P, Zalkin, H. | | 登録日 | 1999-07-09 | | 公開日 | 1999-11-26 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family.
Proc.Natl.Acad.Sci.USA, 96, 1999
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4EX6
 | | Crystal structure of the alnumycin P phosphatase AlnB | | 分子名称: | AlnB, BORIC ACID, MAGNESIUM ION | | 著者 | Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M. | | 登録日 | 2012-04-30 | | 公開日 | 2013-01-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4EX7
 | | Crystal structure of the alnumycin P phosphatase in complex with free phosphate | | 分子名称: | AlnB, BORIC ACID, MAGNESIUM ION, ... | | 著者 | Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M. | | 登録日 | 2012-04-30 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4EX8
 | | Crystal structure of the prealnumycin C-glycosynthase AlnA | | 分子名称: | AlnA, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M. | | 登録日 | 2012-04-30 | | 公開日 | 2013-01-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4EX9
 | | Crystal structure of the prealnumycin C-glycosynthase AlnA in complex with ribulose 5-phosphate | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AlnA, CALCIUM ION, ... | | 著者 | Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M. | | 登録日 | 2012-04-30 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
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2IPI
 | | Crystal Structure of Aclacinomycin Oxidoreductase | | 分子名称: | Aclacinomycin oxidoreductase (AknOx), FLAVIN-ADENINE DINUCLEOTIDE, METHYL (2S,4R)-2-ETHYL-2,5,7-TRIHYDROXY-6,11-DIOXO-4-{[2,3,6-TRIDEOXY-4-O-{2,6-DIDEOXY-4-O-[(2S,6S)-6-METHYL-5-OXOTETRAHYDRO-2H-PYRAN-2-YL]-ALPHA-D-LYXO-HEXOPYRANOSYL}-3-(DIMETHYLAMINO)-D-RIBO-HEXOPYRANOSYL]OXY}-1,2,3,4,6,11-HEXAHYDROTETRACENE-1-CARBOXYLATE | | 著者 | Sultana, A, Kursula, I, Schneider, G, Alexeev, I, Niemi, J, Mantsala, P. | | 登録日 | 2006-10-12 | | 公開日 | 2007-01-23 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structure determination by multiwavelength anomalous diffraction of aclacinomycin oxidoreductase: indications of multidomain pseudomerohedral twinning.
Acta Crystallogr.,Sect.D, 63, 2007
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1TW2
 | | Crystal structure of Carminomycin-4-O-methyltransferase (DnrK) in complex with S-adenosyl-L-homocystein (SAH) and 4-methoxy-e-rhodomycin T (M-ET) | | 分子名称: | Carminomycin 4-O-methyltransferase, METHYL (4R)-2-ETHYL-2,5,12-TRIHYDROXY-7-METHOXY-6,11-DIOXO-4-{[2,3,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-RIBO-HEXOPYRANOSYL]OXY}-1H,2H,3H,4H,6H,11H-TETRACENE-1-CARBOXYLATE, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Jansson, A, Koskiniemi, H, Mantsala, P, Niemi, J, Schneider, G, Structural Proteomics in Europe (SPINE) | | 登録日 | 2004-06-30 | | 公開日 | 2004-09-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products
J.Biol.Chem., 279, 2004
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1SJW
 | | Structure of polyketide cyclase SnoaL | | 分子名称: | METHYL 5,7-DIHYDROXY-2-METHYL-4,6,11-TRIOXO-3,4,6,11-TETRAHYDROTETRACENE-1-CARBOXYLATE, nogalonic acid methyl ester cyclase | | 著者 | Sultana, A, Kallio, P, Jansson, A, Wang, J.S, Neimi, J, Mantsala, P, Schneider, G, Structural Proteomics in Europe (SPINE) | | 登録日 | 2004-03-04 | | 公開日 | 2004-04-27 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation.
Embo J., 23, 2004
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4OSP
 | | The crystal structure of urdamycin C-6 ketoreductase domain UrdMred with bound NADP and rabelomycin | | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxygenase-reductase, rabelomycin | | 著者 | Niiranen, L, Paananen, P, Patrikainen, P, Metsa-Ketela, M. | | 登録日 | 2014-02-13 | | 公開日 | 2014-10-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structure-based engineering of angucyclinone 6-ketoreductases.
Chem.Biol., 21, 2014
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4OSO
 | | The crystal structure of landomycin C-6 ketoreductase LanV with bound NADP and rabelomycin | | 分子名称: | DI(HYDROXYETHYL)ETHER, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Reductase homolog, ... | | 著者 | Paananen, P, Niiranen, L, Patrikainen, P, Metsa-Ketela, M. | | 登録日 | 2014-02-13 | | 公開日 | 2014-10-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure-based engineering of angucyclinone 6-ketoreductases.
Chem.Biol., 21, 2014
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2QA1
 | | Crystal structure of PgaE, an aromatic hydroxylase involved in angucycline biosynthesis | | 分子名称: | 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | | 著者 | Koskiniemi, H, Dobritzsch, D, Metsa-Ketela, M, Kallio, P, Niemi, J, Schneider, G. | | 登録日 | 2007-06-14 | | 公開日 | 2007-08-14 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis
J.Mol.Biol., 372, 2007
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2QA2
 | | Crystal structure of CabE, an aromatic hydroxylase from angucycline biosynthesis, determined to 2.7 A resolution | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Polyketide oxygenase CabE | | 著者 | Koskiniemi, H, Dobritzsch, D, Metsa-Ketela, M, Kallio, P, Niemi, J, Schneider, G. | | 登録日 | 2007-06-14 | | 公開日 | 2007-08-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis
J.Mol.Biol., 372, 2007
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5EBI
 | | Crystal structure of a DNA-RNA chimera in complex with Ba2+ ions: a case of unusual multi-domain twinning | | 分子名称: | BARIUM ION, DNA/RNA (5'-D(*C)-R(P*G)-D(P*C)-R(P*G)-D(P*C)-R(P*G)-3') | | 著者 | Gilski, M, Drozdzal, P, Kierzek, R, Jaskolski, M. | | 登録日 | 2015-10-19 | | 公開日 | 2016-02-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | | 主引用文献 | Atomic resolution structure of a chimeric DNA-RNA Z-type duplex in complex with Ba(2+) ions: a case of complicated multi-domain twinning.
Acta Crystallogr D Struct Biol, 72, 2016
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2GEX
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