1TW3
Crystal structure of Carminomycin-4-O-methyltransferase (DnrK) in complex with S-adenosyl-L-homocystein (SAH) and 4-methoxy-e-rhodomycin T (M-ET)
Summary for 1TW3
Entry DOI | 10.2210/pdb1tw3/pdb |
Related | 1QZZ 1R00 1WT2 |
Descriptor | Carminomycin 4-O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, METHYL (4R)-2-ETHYL-2,5,12-TRIHYDROXY-7-METHOXY-6,11-DIOXO-4-{[2,3,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-RIBO-HEXOPYRANOSYL]OXY}-1H,2H,3H,4H,6H,11H-TETRACENE-1-CARBOXYLATE, ... (4 entities in total) |
Functional Keywords | anthracycline, methyltransferase, methylate, streptomyces, tailoring enzyme, polyketide, s-adenosyl-l-homocystein, transferase |
Biological source | Streptomyces peucetius |
Total number of polymer chains | 2 |
Total formula weight | 80248.64 |
Authors | Jansson, A.,Koskiniemi, H.,Mantsala, P.,Niemi, J.,Schneider, G. (deposition date: 2004-06-30, release date: 2004-09-14, Last modification date: 2024-04-03) |
Primary citation | Jansson, A.,Koskiniemi, H.,Mantsala, P.,Niemi, J.,Schneider, G. Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products J.Biol.Chem., 279:41149-41156, 2004 Cited by PubMed: 15273252DOI: 10.1074/jbc.M407081200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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