1TW3
Crystal structure of Carminomycin-4-O-methyltransferase (DnrK) in complex with S-adenosyl-L-homocystein (SAH) and 4-methoxy-e-rhodomycin T (M-ET)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Carminomycin 4-O-methyltransferase | polymer | 360 | 39140.3 | 2 | UniProt (Q06528) | Streptomyces peucetius | COMT |
| 2 | C, E (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (177678424) PubChem (52224398) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (6419189) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (164157219) PubChem (118374891) PubChem (118560068) PubChem (5284331) PubChem (126969526) PubChem (129105892) PubChem (71170554) PubChem (143518505) PubChem (154578335) PubChem (13231890) PubChem (163054214) PubChem (163335525) | |||
| 3 | D, F (A, B) | METHYL (4R)-2-ETHYL-2,5,12-TRIHYDROXY-7-METHOXY-6,11-DIOXO-4-{[2,3,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-RIBO-HEXOPYRANOSYL]OXY}-1H,2H,3H,4H,6H,11H-TETRACENE-1-CARBOXYLATE | non-polymer | 599.6 | 2 | Chemie (ERT) PubChem (42627031) PubChem (23644200) PubChem (46936605) PubChem (71100896) PubChem (162877114) PubChem (10769874) PubChem (162877115) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 350 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 355 (UniProt: Q06528)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | cloning artifact |
| Ser -3 | - | cloning artifact |
| Pro -2 | - | cloning artifact |
| Asn -1 | - | cloning artifact |
| Ser 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 78280.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1968.1 | |
| All* | Total formula weight | 80248.6 |
