1TW3
Crystal structure of Carminomycin-4-O-methyltransferase (DnrK) in complex with S-adenosyl-L-homocystein (SAH) and 4-methoxy-e-rhodomycin T (M-ET)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Carminomycin 4-O-methyltransferase | polymer | 360 | 39140.3 | 2 | UniProt (Q06528) Pfam (PF00891) | Streptomyces peucetius | COMT |
| 2 | C, E (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 3 | D, F (A, B) | METHYL (4R)-2-ETHYL-2,5,12-TRIHYDROXY-7-METHOXY-6,11-DIOXO-4-{[2,3,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-RIBO-HEXOPYRANOSYL]OXY}-1H,2H,3H,4H,6H,11H-TETRACENE-1-CARBOXYLATE | non-polymer | 599.6 | 2 | Chemie (ERT) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 350 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 355 (UniProt: Q06528)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | cloning artifact |
| Ser -3 | - | cloning artifact |
| Pro -2 | - | cloning artifact |
| Asn -1 | - | cloning artifact |
| Ser 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 78280.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1968.1 | |
| All* | Total formula weight | 80248.6 |
