6J64
 
 | | Crystal structure of human HINT1 mutant complexing with AP4A | | 分子名称: | 2-AMINOETHANESULFONIC ACID, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, Histidine triad nucleotide-binding protein 1 | | 著者 | Wang, J, Fang, P, Guo, M. | | 登録日 | 2019-01-14 | | 公開日 | 2019-09-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | | 主引用文献 | Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells.
Nat Commun, 10, 2019
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6JLH
 | | Structure of SCGN in complex with a Snap25 peptide | | 分子名称: | CALCIUM ION, CHLORIDE ION, Secretagogin, ... | | 著者 | Qin, J, Sun, Q, Jia, D. | | 登録日 | 2019-03-05 | | 公開日 | 2020-03-11 | | 最終更新日 | 2020-04-08 | | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | | 主引用文献 | Structural and mechanistic insights into secretagogin-mediated exocytosis.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6J5Z
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6J65
 | | Crystal structure of human HINT1 mutant complexing with AP4A II | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, Histidine triad nucleotide-binding protein 1 | | 著者 | Wang, J, Fang, P, Guo, M. | | 登録日 | 2019-01-14 | | 公開日 | 2019-09-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells.
Nat Commun, 10, 2019
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6JL7
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6JM5
 | | Crystal structure of TBC1D23 C terminal domain | | 分子名称: | SODIUM ION, TBC1 domain family member 23 | | 著者 | Sun, Q, Huang, W. | | 登録日 | 2019-03-07 | | 公開日 | 2019-10-16 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH.
Proc.Natl.Acad.Sci.USA, 116, 2019
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8GDB
 | | Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein | | 分子名称: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Shenming, H, Mengyao, X, Lei, L, Jianqiang, M, Jinpeng, S. | | 登録日 | 2023-03-03 | | 公開日 | 2024-01-10 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8GDC
 | | Cryo-EM Structure of the Prostaglandin E2 Receptor 3 Coupled to G Protein | | 分子名称: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Shenming, H, Mengyao, X, Lei, L, Yang, D, Shiyi, G, Jinpeng, S. | | 登録日 | 2023-03-03 | | 公開日 | 2024-01-10 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8GDA
 | | Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein | | 分子名称: | (2S,5R)-5-[(1E,3S)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Shenming, H, Mengyao, X, Lei, L, Jiangqian, M, Sheng, C, Jinpeng, S. | | 登録日 | 2023-03-03 | | 公開日 | 2024-01-10 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8GD9
 | | Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein | | 分子名称: | 4-({2-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]butyl}cyclopentyl]ethyl}sulfanyl)butanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Shenming, H, Mengyao, X, Lei, L, Yang, D, Sheng, C, Jinpeng, S. | | 登録日 | 2023-03-03 | | 公開日 | 2024-01-10 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths.
Proc.Natl.Acad.Sci.USA, 120, 2023
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4IA0
 | | Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors | | 分子名称: | 5-bromo-2-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-6-octylpyrimidin-4(3H)-one, MAGNESIUM ION, ZINC ION, ... | | 著者 | Ren, J, Chen, T, Xu, Y. | | 登録日 | 2012-12-05 | | 公開日 | 2014-01-01 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
Bioorg.Med.Chem.Lett., 23, 2013
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4I9Z
 | | Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors | | 分子名称: | 5-bromo-2-{5-[(4-methylpiperazin-1-yl)acetyl]-2-propoxyphenyl}-6-(propan-2-yl)pyrimidin-4(3H)-one, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | | 著者 | Ren, J, Chen, T, Xu, Y. | | 登録日 | 2012-12-05 | | 公開日 | 2014-01-01 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
Bioorg.Med.Chem.Lett., 23, 2013
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8IER
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8IEN
 | | Cryo-EM structure of ATP13A2 in the E2-Pi state | | 分子名称: | MAGNESIUM ION, Polyamine-transporting ATPase 13A2, SPERMINE, ... | | 著者 | Liu, Z.M, Mu, J.Q, Xue, C.Y. | | 登録日 | 2023-02-15 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | Conformational cycle of human polyamine transporter ATP13A2.
Nat Commun, 14, 2023
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8IEM
 | | Cryo-EM structure of ATP13A2 in the E2P state | | 分子名称: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, Polyamine-transporting ATPase 13A2, ... | | 著者 | Liu, Z.M, Mu, J.Q, Xue, C.Y. | | 登録日 | 2023-02-15 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Conformational cycle of human polyamine transporter ATP13A2.
Nat Commun, 14, 2023
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8IEO
 | | Cryo-EM structure of ATP13A2 in the nominal E1P state | | 分子名称: | MAGNESIUM ION, Polyamine-transporting ATPase 13A2, SPERMINE, ... | | 著者 | Liu, Z.M, Mu, J.Q, Xue, C.Y. | | 登録日 | 2023-02-15 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | | 主引用文献 | Conformational cycle of human polyamine transporter ATP13A2.
Nat Commun, 14, 2023
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8IES
 | | Cryo-EM structure of ATP13A2 in the E1P-ADP state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Polyamine-transporting ATPase 13A2, ... | | 著者 | Liu, Z.M, Mu, J.Q, Xue, C.Y. | | 登録日 | 2023-02-15 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | | 主引用文献 | Conformational cycle of human polyamine transporter ATP13A2.
Nat Commun, 14, 2023
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8IEL
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8IEK
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8IT9
 | | Co-crystal structure of FTO bound to 22 | | 分子名称: | 2-OXOGLUTARIC ACID, 2-[(2,6-diethyl-4-pyridin-4-yl-phenyl)amino]-6-(1,4-oxazepan-4-ylmethyl)benzoic acid, Alpha-ketoglutarate-dependent dioxygenase FTO | | 著者 | Yang, C.-G, Gan, J.H. | | 登録日 | 2023-03-22 | | 公開日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties.
J.Med.Chem., 66, 2023
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5ZGD
 | | hnRNPA1 reversible amyloid core GFGGNDNFG (residues 209-217) determined by X-ray | | 分子名称: | GLY-PHE-GLY-GLY-ASN-ASP-ASN-PHE-GLY | | 著者 | Gui, X, Xie, M, Zhao, M, Luo, F, He, J, Li, D, Liu, C. | | 登録日 | 2018-03-08 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.401 Å) | | 主引用文献 | Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Nat Commun, 10, 2019
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5ZGL
 | | hnRNP A1 segment GGGYGGS (residues 234-240) | | 分子名称: | 7-mer peptide from Heterogeneous nuclear ribonucleoprotein A1 | | 著者 | Xie, M, Luo, F, Gui, X, Zhao, M, He, J, Li, D, Liu, C. | | 登録日 | 2018-03-09 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | | 主引用文献 | Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Nat Commun, 10, 2019
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4LZO
 | | Crystal structure of human PRS1 A87T mutant | | 分子名称: | Ribose-phosphate pyrophosphokinase 1, SULFATE ION | | 著者 | Chen, P, Teng, M, Li, X. | | 登録日 | 2013-07-31 | | 公開日 | 2015-02-04 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | | 主引用文献 | Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
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4LYG
 | | Crystal structure of human PRS1 E43T mutant | | 分子名称: | Ribose-phosphate pyrophosphokinase 1, SULFATE ION | | 著者 | Chen, P, Teng, M, Li, X. | | 登録日 | 2013-07-31 | | 公開日 | 2015-02-04 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
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4LZN
 | | Crystal structure of human PRS1 D65N mutant | | 分子名称: | Ribose-phosphate pyrophosphokinase 1, SULFATE ION | | 著者 | Chen, P, Teng, M, Li, X. | | 登録日 | 2013-07-31 | | 公開日 | 2015-02-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
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