8IT9
Co-crystal structure of FTO bound to 22
Summary for 8IT9
Entry DOI | 10.2210/pdb8it9/pdb |
Descriptor | Alpha-ketoglutarate-dependent dioxygenase FTO, 2-[(2,6-diethyl-4-pyridin-4-yl-phenyl)amino]-6-(1,4-oxazepan-4-ylmethyl)benzoic acid, 2-OXOGLUTARIC ACID, ... (4 entities in total) |
Functional Keywords | rna demethylase, rna binding protein, protein binding |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 57066.32 |
Authors | |
Primary citation | Xiao, P.,Duan, Z.,Liu, Z.,Chen, L.,Zhang, D.,Liu, L.,Zhou, C.,Gan, J.,Dong, Z.,Yang, C.G. Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties. J.Med.Chem., 66:9731-9752, 2023 Cited by PubMed: 37418628DOI: 10.1021/acs.jmedchem.3c00543 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
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