6J5Z

Crystal structure of human HINT1 mutant complexing with AP3A

Summary for 6J5Z

Entry DOI	10.2210/pdb6j5z/pdb
Related	5ED3 5ED6 6J53 6J58 6J5S
Descriptor	Histidine triad nucleotide-binding protein 1, ETHANESULFONIC ACID, ADENOSINE, ... (4 entities in total)
Functional Keywords	hydrolase, nucleotide binding, regulation of transcription, signal transduction
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	56473.00
Authors	Wang, J.,Fang, P.,Guo, M. (deposition date: 2019-01-12, release date: 2019-09-25, Last modification date: 2023-11-22)
Primary citation	Yu, J.,Liu, Z.,Liang, Y.,Luo, F.,Zhang, J.,Tian, C.,Motzik, A.,Zheng, M.,Kang, J.,Zhong, G.,Liu, C.,Fang, P.,Guo, M.,Razin, E.,Wang, J. Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells. Nat Commun, 10:4664-4664, 2019 Cited by PubMed: 31604935 DOI: 10.1038/s41467-019-12710-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation