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6N7V
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BU of 6n7v by Molmil
Structure of bacteriophage T7 gp4 (helicase-primase, E343Q mutant) in complex with ssDNA, dTTP, AC dinucleotide, and CTP (from multiple lead complexes)
分子名称: DNA (93-MER), DNA primase/helicase, MAGNESIUM ION, ...
著者Gao, Y, Fox, T, Val, N, Yang, W.
登録日2018-11-28
公開日2019-03-06
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structures and operating principles of the replisome.
Science, 363, 2019
6N9W
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BU of 6n9w by Molmil
Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and gp4 (helicase/primase) bound to DNA including RNA/DNA hybrid, and an incoming dTTP (LagS2)
分子名称: DNA primase/helicase, DNA-directed DNA polymerase, MAGNESIUM ION, ...
著者Gao, Y, Cui, Y, Zhou, Z, Yang, W.
登録日2018-12-04
公開日2019-03-06
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structures and operating principles of the replisome.
Science, 363, 2019
8H3T
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BU of 8h3t by Molmil
The crystal structure of AlpH
分子名称: AlpH, GLYCEROL
著者Zhao, Y, Li, M, Jiang, M, Pan, L.F.
登録日2022-10-09
公開日2023-09-13
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.866 Å)
主引用文献O-methyltransferase-like enzyme catalyzed diazo installation in polyketide biosynthesis.
Nat Commun, 14, 2023
8I4Y
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BU of 8i4y by Molmil
CalA3 complex structure with amidation product
分子名称: 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, 3-HYDROXYANTHRANILIC ACID, Beta-ketoacyl-acyl-carrier-protein synthase I
著者Wang, J, Wang, Z.
登録日2023-01-21
公開日2023-02-22
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (3.84 Å)
主引用文献C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
8I4Z
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BU of 8i4z by Molmil
CalA3 with hydrolysis product
分子名称: 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, Beta-ketoacyl-acyl-carrier-protein synthase I
著者Wang, J, Wang, Z.
登録日2023-01-21
公開日2023-02-22
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (3.97 Å)
主引用文献C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
8HVR
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BU of 8hvr by Molmil
Cryo-EM structure of AfsR-dependent transcription activation complex with afsS promoter
分子名称: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Wang, Y, Zheng, J.
登録日2022-12-27
公開日2023-12-27
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Structural and functional characterization of AfsR, an SARP family transcriptional activator of antibiotic biosynthesis in Streptomyces.
Plos Biol., 22, 2024
8JKE
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AfsR(T337A) transcription activation complex
分子名称: DNA(65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Wang, Y, Zheng, J.
登録日2023-06-01
公開日2024-02-14
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.67 Å)
主引用文献Structural and functional characterization of AfsR, an SARP family transcriptional activator of antibiotic biosynthesis in Streptomyces.
Plos Biol., 22, 2024
5W84
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BU of 5w84 by Molmil
CRYSTAL STRUCTURE OF IRAK-4 WITH A 4,6-DIAMINONICOTINAMIDE INHIBITOR (COMPOUND NUMBER 4)
分子名称: 4-(benzylamino)-6-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]pyridine-3-carboxamide, Interleukin-1 receptor-associated kinase 4
著者Sack, J.S.
登録日2017-06-21
公開日2017-10-11
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5XWW
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BU of 5xww by Molmil
Substrate-bound Structure of G355T/Q364H mutant of a Ketoreductase from amphotericin Polyketide Synthases
分子名称: AmphB, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, S-[2-[3-[[(2R)-3,3-dimethyl-2,4-bis(oxidanyl)butanoyl]amino]propanoylamino]ethyl] (2R)-2-methyl-3-oxidanylidene-pentanethioate
著者Liu, C, Zheng, J.
登録日2017-06-30
公開日2018-06-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.
J. Struct. Biol., 203, 2018
5XWV
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BU of 5xwv by Molmil
Substrate-bound Structure of a Ketoreductase from the Second Module of the amphotericin Polyketide Synthases
分子名称: AmphB, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, S-[2-[3-[[(2R)-3,3-dimethyl-2,4-bis(oxidanyl)butanoyl]amino]propanoylamino]ethyl] (2R)-2-methyl-3-oxidanylidene-pentanethioate
著者Liu, C, Zheng, J.
登録日2017-06-30
公開日2018-06-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.
J. Struct. Biol., 203, 2018
6BJJ
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BU of 6bjj by Molmil
Human ABO(H) blood group glycosyltransferase GTB D302A mutant
分子名称: ABO blood group (Transferase A, alpha 1-3-N-acetylgalactosaminyltransferase transferase B, alpha 1-3-galactosyltransferase)
著者Gagnon, S.M.L, Legg, M.S.G, Evans, S.V.
登録日2017-11-06
公開日2018-09-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases.
Glycobiology, 28, 2018
6BJI
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BU of 6bji by Molmil
Human ABO(H) blood group glycosyltransferase GTA D302C mutant
分子名称: GLYCEROL, Histo-blood group ABO system transferase
著者Gagnon, S.M.L, Legg, M.S.G, Evans, S.V.
登録日2017-11-06
公開日2018-09-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases.
Glycobiology, 28, 2018
6BJK
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BU of 6bjk by Molmil
Human ABO(H) blood group glycosyltransferase GTB D302C mutant
分子名称: ABO blood group (Transferase A, alpha 1-3-N-acetylgalactosaminyltransferase transferase B, alpha 1-3-galactosyltransferase), ...
著者Gagnon, S.M.L, Legg, M.S.G, Evans, S.V.
登録日2017-11-06
公開日2018-09-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases.
Glycobiology, 28, 2018
6BJL
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BU of 6bjl by Molmil
Human ABO(H) blood group glycosyltransferase GTB D302L mutant
分子名称: ABO blood group (Transferase A, alpha 1-3-N-acetylgalactosaminyltransferase transferase B, alpha 1-3-galactosyltransferase), ...
著者Gagnon, S.M.L, Legg, M.S.G, Evans, S.V.
登録日2017-11-06
公開日2018-09-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases.
Glycobiology, 28, 2018
6BJM
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BU of 6bjm by Molmil
Human ABO(H) blood group glycosyltransferase GTB R188K mutant
分子名称: ABO blood group (Transferase A, alpha 1-3-N-acetylgalactosaminyltransferase transferase B, alpha 1-3-galactosyltransferase), ...
著者Gagnon, S.M.L, Legg, M.S.G, Evans, S.V.
登録日2017-11-06
公開日2018-09-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases.
Glycobiology, 28, 2018
7VO0
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BU of 7vo0 by Molmil
Streptomyces coelicolor zinc uptake regulator complexed with zinc and DNA (trimer of dimers)
分子名称: DNA_NT (84-MER), DNA_T (84-MER), Putative metal uptake regulation protein, ...
著者Yang, X, Zheng, J.
登録日2021-10-12
公開日2022-08-03
最終更新日2022-08-24
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural basis of Streptomyces transcription activation by zinc uptake regulator.
Nucleic Acids Res., 50, 2022
7VPD
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BU of 7vpd by Molmil
Cryo-EM structure of Streptomyces coelicolor RNAP-promoter open complex with one Zur dimers
分子名称: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Yang, X, Zheng, J.
登録日2021-10-15
公開日2022-08-03
最終更新日2022-08-24
実験手法ELECTRON MICROSCOPY (3.77 Å)
主引用文献Structural basis of Streptomyces transcription activation by zinc uptake regulator.
Nucleic Acids Res., 50, 2022
7VPZ
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Cryo-EM structure of Streptomyces coelicolor transcription initial complex with one Zur dimer
分子名称: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Yang, X, Zheng, J.
登録日2021-10-18
公開日2022-08-03
最終更新日2022-08-24
実験手法ELECTRON MICROSCOPY (4.14 Å)
主引用文献Structural basis of Streptomyces transcription activation by zinc uptake regulator.
Nucleic Acids Res., 50, 2022
7VO9
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Streptomyces coelicolor zinc uptake regulator complexed with zinc and DNA (dimer of dimers)
分子名称: DNA (84-MER), Putative metal uptake regulation protein, ZINC ION
著者Yang, X, Zheng, J.
登録日2021-10-13
公開日2022-08-03
最終更新日2022-08-24
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural basis of Streptomyces transcription activation by zinc uptake regulator.
Nucleic Acids Res., 50, 2022
7VWK
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The product template domain of AviM
分子名称: Polyketide synthase
著者Feng, Y, Yang, X, Zheng, J.
登録日2021-11-10
公開日2022-06-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Streptomyces viridochromogenes product template domain represents an evolutionary intermediate between dehydratase and aldol cyclase of type I polyketide synthases.
Commun Biol, 5, 2022
7WVZ
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CalA3_modular PKS_KS-AT-DH-KR
分子名称: Beta-ketoacyl-acyl-carrier-protein synthase I
著者Wang, J, Wang, Z.
登録日2022-02-12
公開日2023-02-22
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
7X76
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BU of 7x76 by Molmil
Cryo-EM structure of Streptomyces coelicolor RNAP-promoter open complex with two Zur dimers
分子名称: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Yang, X, Zheng, J.
登録日2022-03-09
公開日2022-08-03
最終更新日2022-08-24
実験手法ELECTRON MICROSCOPY (3.67 Å)
主引用文献Structural basis of Streptomyces transcription activation by zinc uptake regulator.
Nucleic Acids Res., 50, 2022
7X75
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BU of 7x75 by Molmil
Cryo-EM structure of Streptomyces coelicolor RNAP-promoter open complex with three Zur dimers
分子名称: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Yang, X, Zheng, J.
登録日2022-03-09
公開日2022-08-03
最終更新日2022-08-24
実験手法ELECTRON MICROSCOPY (3.45 Å)
主引用文献Structural basis of Streptomyces transcription activation by zinc uptake regulator.
Nucleic Acids Res., 50, 2022
7X74
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BU of 7x74 by Molmil
Cryo-EM structure of Streptomyces coelicolor transcription initial complex with two Zur dimers.
分子名称: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Yang, X, Zheng, J.
登録日2022-03-09
公開日2022-08-03
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural basis of Streptomyces transcription activation by zinc uptake regulator.
Nucleic Acids Res., 50, 2022

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