8FCE
 
 | | HIV-1 Reverse Transcriptase in complex with 7-membered bicyclic core NNRTI | | 分子名称: | 4-[(9-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]benzonitrile, L(+)-TARTARIC ACID, p51 RT, ... | | 著者 | Lansdon, E.B. | | 登録日 | 2022-12-01 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-02-22 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties.
J.Med.Chem., 66, 2023
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8FCD
 | | HIV-1 Reverse Transcriptase in complex with 6-membered bicyclic core NNRTI | | 分子名称: | 4-[(8-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino]benzonitrile, L(+)-TARTARIC ACID, p51 RT, ... | | 著者 | Lansdon, E.B. | | 登録日 | 2022-12-01 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-02-22 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties.
J.Med.Chem., 66, 2023
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8FCC
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3A5U
 | | Promiscuity and specificity in DNA binding to SSB: Insights from the structure of the Mycobacterium smegmatis SSB-ssDNA complex | | 分子名称: | DNA (31-MER), Single-stranded DNA-binding protein | | 著者 | Kaushal, P.S, Manjunath, G.P, Sekar, K, Muniyappa, K, Vijayan, M. | | 登録日 | 2009-08-12 | | 公開日 | 2010-08-18 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Promiscuity and specificity in DNA binding to SSB: Insights from the structure of the Mycobacterium smegmatis SSB-ssDNA complex.
To be Published, 2009
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2C83
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2C84
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4S3G
 | | Structure of the F249X mutant of Phosphatidylinositol-specific phospholipase C from Staphylococcus aureus | | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, ACETATE ION | | 著者 | He, T, Gershenson, A, Eyles, S.J, Gao, J, Roberts, M.F. | | 登録日 | 2015-01-26 | | 公開日 | 2015-07-01 | | 最終更新日 | 2015-08-19 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Fluorinated Aromatic Amino Acids Distinguish Cation-pi Interactions from Membrane Insertion.
J.Biol.Chem., 290, 2015
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4RV3
 | | Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus | | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, ACETATE ION | | 著者 | He, T, Gershenson, A, Eyles, S.J, Gao, J, Roberts, M.F. | | 登録日 | 2014-11-24 | | 公開日 | 2015-07-01 | | 最終更新日 | 2018-08-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Fluorinated Aromatic Amino Acids Distinguish Cation-pi Interactions from Membrane Insertion.
J.Biol.Chem., 290, 2015
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3OPO
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3OW7
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2IY7
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2IY8
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7DR4
 | | Complex of anti-human IL-2 antibody and human IL-2 | | 分子名称: | Interleukin-2, anti-human IL-2 antibody, mouse Ig G, ... | | 著者 | Kim, M.S, Kim, J.E. | | 登録日 | 2020-12-25 | | 公開日 | 2021-04-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Crystal structure of human interleukin-2 in complex with TCB2, a new antibody-drug candidate with antitumor activity.
Oncoimmunology, 10, 2021
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5YCN
 | | Human PPARgamma ligand binding domain complexed with Lobeglitazone | | 分子名称: | (5S)-5-[[4-[2-[[6-(4-methoxyphenoxy)pyrimidin-4-yl]-methyl-amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione, Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma | | 著者 | Jang, J.Y, Han, B.W. | | 登録日 | 2017-09-07 | | 公開日 | 2018-09-12 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPAR gamma.
Sci Rep, 8, 2018
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5YCP
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6NZV
 | | Crystal structure of HCV NS3/4A protease in complex with compound 12 | | 分子名称: | (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide, HCV NS3/4A protease, SULFATE ION, ... | | 著者 | Appleby, T.C, Taylor, J.G. | | 登録日 | 2019-02-14 | | 公開日 | 2019-07-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®.
Bioorg.Med.Chem.Lett., 29, 2019
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