4AAZ
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![BU of 4aaz by Molmil](/molmil-images/mine/4aaz) | X-ray structure of Nicotiana alata Defensin 1 NaD1 | Descriptor: | 1,2-ETHANEDIOL, FLOWER-SPECIFIC DEFENSIN, PHOSPHATE ION | Authors: | Lay, F.T, Mills, G.D, Hulett, M.D, Kvansakul, M. | Deposit date: | 2011-12-06 | Release date: | 2012-04-25 | Last modified: | 2012-08-08 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Dimerization of Plant Defensin Nad1 Enhances its Antifungal Activity. J.Biol.Chem., 287, 2012
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1MR4
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![BU of 1mr4 by Molmil](/molmil-images/mine/1mr4) | Solution Structure of NaD1 from Nicotiana alata | Descriptor: | Nicotiana alata plant defensin 1 (NaD1) | Authors: | Lay, F.T, Schirra, H.J, Scanlon, M.J, Anderson, M.A, Craik, D.J. | Deposit date: | 2002-09-18 | Release date: | 2003-09-18 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | The Three-dimensional Solution Structure of NaD1, a New Floral Defensin from Nicotiana alata and its Application to a Homology Model of the Crop Defense Protein alfAFP J.MOL.BIOL., 325, 2003
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4AB0
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![BU of 4ab0 by Molmil](/molmil-images/mine/4ab0) | X-ray crystal structure of Nicotiana alata defensin NaD1 | Descriptor: | FLOWER-SPECIFIC DEFENSIN, PHOSPHATE ION | Authors: | Mills, G.D, Lay, F.T, Hulett, M.D, Kvansakul, M. | Deposit date: | 2011-12-06 | Release date: | 2012-04-25 | Last modified: | 2012-06-20 | Method: | X-RAY DIFFRACTION (1.636 Å) | Cite: | Dimerization of Plant Defensin Nad1 Enhances its Antifungal Activity. J.Biol.Chem., 287, 2012
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4CQK
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![BU of 4cqk by Molmil](/molmil-images/mine/4cqk) | Crystal structure of ligand-bound NaD1 | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, FLOWER-SPECIFIC DEFENSIN, SULFATE ION, ... | Authors: | Lay, F.T, Mills, G.M, Poon, I.K.H, Baxter, A.A, Hulett, M.D, Kvansakul, M. | Deposit date: | 2014-02-17 | Release date: | 2014-04-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Phosphoinositide-Mediated Oligomerization of a Defensin Induces Cell Lysis. Elife, 3, 2014
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5VYP
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![BU of 5vyp by Molmil](/molmil-images/mine/5vyp) | Crystal structure of the Plant Defensin NsD7 bound to PIP2 | Descriptor: | Defensin NsD7, GLYCEROL, SULFATE ION, ... | Authors: | Jarva, M, Lay, F.T, Hulett, M, Kvansakul, M. | Deposit date: | 2017-05-25 | Release date: | 2017-08-02 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the defensin NsD7 in complex with PIP2 reveals that defensin : lipid oligomer topologies are dependent on lipid type. FEBS Lett., 591, 2017
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4UJ0
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![BU of 4uj0 by Molmil](/molmil-images/mine/4uj0) | Crystal structure of the tomato defensin TPP3 | Descriptor: | ACETATE ION, FLOWER-SPECIFIC GAMMA-THIONIN-LIKE PROTEIN/ACIDIC PROTEIN | Authors: | Richter, V, Lay, F.T, Hulett, M.D, Kvansakul, M. | Deposit date: | 2015-04-07 | Release date: | 2015-04-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Tomato Defensin Tpp3 Binds Phosphatidylinositol (4,5)-Bisphosphate Via a Conserved Dimeric Cationic Grip Conformation to Mediate Cell Lysis. Mol.Cell.Biol., 35, 2015
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5KK4
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![BU of 5kk4 by Molmil](/molmil-images/mine/5kk4) | Crystal Structure of the Plant Defensin NsD7 bound to Phosphatidic Acid | Descriptor: | (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Kvansakul, M, Hulett, M.D, Lay, F.T. | Deposit date: | 2016-06-21 | Release date: | 2016-10-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin-lipid oligomeric assemblies and membrane permeabilization. Proc.Natl.Acad.Sci.USA, 113, 2016
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6B55
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![BU of 6b55 by Molmil](/molmil-images/mine/6b55) | Crystal structure of the Plant Defensin NaD1 complexed with phosphatidic acid | Descriptor: | 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHATE, 1,2-ETHANEDIOL, Flower-specific defensin, ... | Authors: | Jarva, M, Phan, K, Humble, C, Lay, F.T, Hulett, M, Kvansakul, M. | Deposit date: | 2017-09-28 | Release date: | 2018-05-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | X-ray structure of a carpet-like antimicrobial defensin-phospholipid membrane disruption complex. Nat Commun, 9, 2018
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6CS9
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![BU of 6cs9 by Molmil](/molmil-images/mine/6cs9) | Crystal structure of human beta-defensin 2 in complex with PIP2 | Descriptor: | Beta-defensin 4A, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Jarva, M, Phan, K, Lay, F.T, Humble, C, Hulett, M, Kvansakul, M. | Deposit date: | 2018-03-20 | Release date: | 2018-07-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Human beta-defensin 2 killsCandida albicansthrough phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization. Sci Adv, 4, 2018
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1N4N
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![BU of 1n4n by Molmil](/molmil-images/mine/1n4n) | Structure of the Plant Defensin PhD1 from Petunia Hybrida | Descriptor: | floral defensin-like protein 1 | Authors: | Janssen, B.J.C, Schirra, H.J, Lay, F.T, Anderson, M.A, Craik, D.J. | Deposit date: | 2002-11-01 | Release date: | 2003-11-01 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Structure of Petunia hybrida defensin 1, a novel plant defensin with five disulfide bonds Biochemistry, 42, 2003
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6MRY
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![BU of 6mry by Molmil](/molmil-images/mine/6mry) | NoD173 plant defensin | Descriptor: | 1,2-ETHANEDIOL, 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, CHLORIDE ION, ... | Authors: | Caria, S, Kvansakul, M. | Deposit date: | 2018-10-15 | Release date: | 2019-04-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and functional characterization of the membrane-permeabilizing activity ofNicotiana occidentalisdefensin NoD173 and protein engineering to enhance oncolysis. Faseb J., 33, 2019
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6DMZ
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![BU of 6dmz by Molmil](/molmil-images/mine/6dmz) | Solution structure of ZmD32 | Descriptor: | Flower-specific gamma-thionin | Authors: | Harvey, P.J, Craik, D.J. | Deposit date: | 2018-06-05 | Release date: | 2019-05-15 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32. Front Microbiol, 10, 2019
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7T9R
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![BU of 7t9r by Molmil](/molmil-images/mine/7t9r) | Crystal structure of Crocodile defensin CpoBD13:phosphatidic acid complex | Descriptor: | (R)-2-(FORMYLOXY)-3-(PHOSPHONOOXY)PROPYL PENTANOATE, 1,2-ETHANEDIOL, CpoBD13, ... | Authors: | Kvansakul, M, Williams, S, Hulett, M.D. | Deposit date: | 2021-12-19 | Release date: | 2023-01-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crocodile defensin (CpoBD13) antifungal activity via pH-dependent phospholipid targeting and membrane disruption. Nat Commun, 14, 2023
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7T9Q
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![BU of 7t9q by Molmil](/molmil-images/mine/7t9q) | Crystal structure of Crocodile defensin CpoBD13 | Descriptor: | 1,2-ETHANEDIOL, CITRATE ANION, CpoBD13 | Authors: | Kvansakul, M, Williams, S, Hulett, M.D. | Deposit date: | 2021-12-19 | Release date: | 2023-01-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crocodile defensin (CpoBD13) antifungal activity via pH-dependent phospholipid targeting and membrane disruption. Nat Commun, 14, 2023
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