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4R04
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BU of 4r04 by Molmil
Clostridium difficile Toxin A (TcdA)
分子名称: Toxin A, ZINC ION
著者Lacy, D.B, Spiller, B.W, Rutherford, S.A.
登録日2014-07-29
公開日2016-01-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.26 Å)
主引用文献Glucosyl Transferase Structure
Nat Microbiol, 2016
1SHT
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BU of 1sht by Molmil
Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor
分子名称: ACETATE ION, Anthrax toxin receptor 2, MAGNESIUM ION
著者Lacy, D.B, Wigelsworth, D.J, Scobie, H.M, Young, J.A.T, Collier, R.J.
登録日2004-02-26
公開日2004-04-13
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor
Proc.Natl.Acad.Sci.USA, 101, 2004
1SHU
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BU of 1shu by Molmil
Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor
分子名称: Anthrax toxin receptor 2, MAGNESIUM ION
著者Lacy, D.B, Wigelsworth, D.J, Scobie, H.M, Young, J.A.T, Collier, R.J.
登録日2004-02-26
公開日2004-04-13
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor
Proc.Natl.Acad.Sci.USA, 101, 2004
1TZN
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BU of 1tzn by Molmil
Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore bound to the VWA domain of CMG2, an anthrax toxin receptor
分子名称: Anthrax toxin receptor 2, CALCIUM ION, MAGNESIUM ION, ...
著者Lacy, D.B, Wigelsworth, D.J, Melnyk, R.A, Collier, R.J.
登録日2004-07-10
公開日2004-08-17
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (4.3 Å)
主引用文献Structure of heptameric protective antigen bound to an anthrax toxin receptor: A role for receptor in pH-dependent pore formation
Proc.Natl.Acad.Sci.USA, 101, 2004
1TZO
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BU of 1tzo by Molmil
Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore
分子名称: CALCIUM ION, Protective antigen
著者Lacy, D.B, Wigelsworth, D.J, Melnyk, R.A, Collier, R.J.
登録日2004-07-10
公開日2004-08-17
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structure of heptameric protective antigen bound to an anthrax toxin receptor: A role for receptor in pH-dependent pore formation
Proc.Natl.Acad.Sci.USA, 101, 2004
3BTA
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BU of 3bta by Molmil
CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE A
分子名称: PROTEIN (BOTULINUM NEUROTOXIN TYPE A), ZINC ION
著者Stevens, R.C, Lacy, D.B.
登録日1998-08-12
公開日1999-10-01
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of botulinum neurotoxin type A and implications for toxicity.
Nat.Struct.Biol., 5, 1998
6O2N
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BU of 6o2n by Molmil
CDTb Double Heptamer Short Form Modeled from Cryo-EM Map Reconstructed using C7 Symmetry
分子名称: ADP-ribosyltransferase binding component
著者Lacy, D.B, Sheedlo, M.J, Anderson, D.M.
登録日2019-02-24
公開日2019-10-30
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore.
Nat Microbiol, 5, 2020
6O2M
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BU of 6o2m by Molmil
CDTb Double Heptamer Long Form Modeled from Cryo-EM Map Reconstructed using C7 Symmetry
分子名称: ADP-ribosyltransferase binding component
著者Lacy, D.B, Sheedlo, M.J, Anderson, D.M.
登録日2019-02-24
公開日2019-10-30
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (6.3 Å)
主引用文献Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore.
Nat Microbiol, 5, 2020
6O2O
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BU of 6o2o by Molmil
CDTb Double Heptamer Short Form Modeled from Cryo-EM Map Reconstructed using C1 Symmetry
分子名称: ADP-ribosyltransferase binding component
著者Lacy, D.B, Sheedlo, M.J, Anderson, D.M.
登録日2019-02-24
公開日2019-10-30
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.53 Å)
主引用文献Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore.
Nat Microbiol, 5, 2020
6OKU
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BU of 6oku by Molmil
CDTb Double Heptamer Long Form Mask 3 Modeled from Cryo-EM Map Reconstructed using C7 Symmetry
分子名称: ADP-ribosyltransferase binding component
著者Lacy, D.B, Sheedlo, M.J, Anderson, D.M.
登録日2019-04-15
公開日2019-10-30
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore.
Nat Microbiol, 5, 2020
6OKS
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BU of 6oks by Molmil
CDTb Double Heptamer Long Form Mask 1 Modeled from Cryo-EM Map Reconstructed using C7 Symmetry
分子名称: ADP-ribosyltransferase binding component
著者Lacy, D.B, Sheedlo, M.J, Anderson, D.M.
登録日2019-04-15
公開日2019-10-30
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore.
Nat Microbiol, 5, 2020
6OKT
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BU of 6okt by Molmil
CDTb Double Heptamer Long Form Mask 1 Modeled from Cryo-EM Map Reconstructed using C7 Symmetry
分子名称: ADP-ribosyltransferase binding component
著者Lacy, D.B, Sheedlo, M.J, Anderson, D.M.
登録日2019-04-15
公開日2019-10-30
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore.
Nat Microbiol, 5, 2020
6OKR
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BU of 6okr by Molmil
CDTb Pre-Insertion form Modeled from Cryo-EM Map Reconstructed using C7 Symmetry
分子名称: ADP-ribosyltransferase binding component
著者Lacy, D.B, Sheedlo, M.J, Anderson, D.M.
登録日2019-04-15
公開日2019-10-30
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore.
Nat Microbiol, 5, 2020
3SRZ
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BU of 3srz by Molmil
Clostridium difficile toxin A (TcdA) glucolsyltransferase domain bound to UDP-glucose
分子名称: MANGANESE (II) ION, Toxin A, URIDINE-5'-DIPHOSPHATE-GLUCOSE
著者Pruitt, R.N, Chumbler, N.M, Farrow, M.A, Seeback, S.A, Friedman, D.B, Spiller, B.W, Lacy, D.B.
登録日2011-07-07
公開日2012-02-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity.
J.Biol.Chem., 287, 2012
3SS1
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BU of 3ss1 by Molmil
Clostridium difficile toxin A (TcdA) glucolsyltransferase domain
分子名称: MANGANESE (II) ION, Toxin A
著者Pruitt, R.N, Chumbler, N.M, Farrow, M.A, Seeback, S.A, Friedman, D.B, Spiller, B.W, Lacy, D.B.
登録日2011-07-07
公開日2012-02-01
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.202 Å)
主引用文献Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity.
J.Biol.Chem., 287, 2012
5VQM
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BU of 5vqm by Molmil
Clostridium difficile TcdB-GTD bound to PA41 Fab
分子名称: PA41 FAB HEAVY CHAIN, PA41 FAB LIGHT CHAIN, Toxin B
著者Kroh, H.K, Spiller, B.W, Lacy, D.B.
登録日2017-05-09
公開日2017-12-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.
J. Biol. Chem., 293, 2018
6V1S
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BU of 6v1s by Molmil
Structure of the Clostridioides difficile transferase toxin
分子名称: ADP-ribosylating binary toxin enzymatic subunit CdtA, ADP-ribosyltransferase binding component, CALCIUM ION
著者Sheedlo, M.J, Anderson, D.M, Thomas, A.K, Lacy, D.B.
登録日2019-11-21
公開日2020-03-18
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural elucidation of theClostridioides difficiletransferase toxin reveals a single-site binding mode for the enzyme.
Proc.Natl.Acad.Sci.USA, 117, 2020
3MPP
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BU of 3mpp by Molmil
Botulinum Neurotoxin Type G Receptor Binding Domain
分子名称: Botulinum neurotoxin type G
著者Schmitt, J.M, Lacy, D.B.
登録日2010-04-27
公開日2010-06-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structural analysis of botulinum neurotoxin type G receptor binding .
Biochemistry, 49, 2010
1J7N
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BU of 1j7n by Molmil
Anthrax Toxin Lethal factor
分子名称: Lethal Factor precursor, SULFATE ION, ZINC ION
著者Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C.
登録日2001-05-17
公開日2001-11-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
1JKY
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BU of 1jky by Molmil
Crystal Structure of the Anthrax Lethal Factor (LF): Wild-type LF Complexed with the N-terminal Sequence of MAPKK2
分子名称: Lethal Factor, mitogen-activated protein kinase kinase 2
著者Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C.
登録日2001-07-13
公開日2001-11-07
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
5UQL
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BU of 5uql by Molmil
Clostridium difficile toxin A (TcdA) glucosyltransferase domain in complex with U2F
分子名称: MANGANESE (II) ION, Toxin A, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE
著者Alvin, J.W, Lacy, D.B.
登録日2017-02-08
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5UQT
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BU of 5uqt by Molmil
Clostridium difficile Toxin B (TcdB) glucosyltransferase domain co-crystallized with apigenin
分子名称: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, MANGANESE (II) ION, Toxin B
著者Alvin, J.W, Lacy, D.B.
登録日2017-02-08
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5UQK
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BU of 5uqk by Molmil
Clostridium difficile toxin A (TcdA) glucosyltransferase domain in complex with U2F
分子名称: MANGANESE (II) ION, Toxin A, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE
著者Alvin, J.W, Lacy, D.B.
登録日2017-02-08
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.851 Å)
主引用文献Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5UQN
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Clostridium difficile Toxin B (TcdB) glucosyltransferase domain in complex with U2F
分子名称: MANGANESE (II) ION, SULFATE ION, Toxin B, ...
著者Alvin, J.W, Lacy, D.B.
登録日2017-02-08
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5UMI
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BU of 5umi by Molmil
Clostridium difficile TcdA-CROPs bound to PA50 Fab
分子名称: PA50 Fab Heavy chain, PA50 Fab Light chain, Toxin A
著者Kroh, H.K, Chandrasekaran, R, Rosenthal, K, Woods, R, Jin, X, Ohi, M.D, Nyborg, A.C, Rainey, G.J, Warrener, P, Spiller, B.W, Lacy, D.B.
登録日2017-01-27
公開日2017-07-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.23 Å)
主引用文献Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.
J. Biol. Chem., 292, 2017

 

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