1NM6
| thrombin in complex with selective macrocyclic inhibitor at 1.8A | Descriptor: | (11S)-11-BENZYL-6-CHLORO-1,2,10,11,12,13,14,15,16,17,18,19-DODECAHYDRO-5,9-METHANO-2,5,8,10,13,17-BENZOHEXAAZACYCLOHENICOSINE-3,24-DIONE, Hirudin, thrombin | Authors: | Nantermet, P.G, Barrow, J.C, Newton, C.L, Pellicore, J.M, Young, M, Lewis, S.D, Lucas, B.J, Krueger, J.A, McMasters, D.R, Yan, Y, Kuo, L.C, Vacca, J.P, Selnick, H.G. | Deposit date: | 2003-01-09 | Release date: | 2003-09-02 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Design and synthesis of potent and selective macrocyclic thrombin inhibitors Bioorg.Med.Chem.Lett., 13, 2003
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1NT1
| thrombin in complex with selective macrocyclic inhibitor | Descriptor: | (6R,21AS)-17-CHLORO-6-CYCLOHEXYL-2,3,6,7,10,11,19,20-OCTAHYDRO-1H,5H-PYRROLO[1,2-K][1,4,8,11,14]BENZOXATETRAAZA-CYCLOHEPTADECINE-5,8,12,21(9H,13H,21AH)-TETRONE, Hirudin, thrombin | Authors: | Nantermet, P.G, Barrow, J.C, Newton, C.L, Pellicore, J.M, Young, M, Lewis, S.D, Lucas, B.J, Krueger, J.A, McMasters, D.R, Yan, Y, Kuo, L.C, Vacca, J.P, Selnick, H.G. | Deposit date: | 2003-01-28 | Release date: | 2003-09-02 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design and synthesis of potent and selective macrocyclic thrombin inhibitors Bioorg.Med.Chem.Lett., 13, 2003
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1OAR
| Fv IgE SPE-7 in complex with Alizarin Red | Descriptor: | 1,2-ETHANEDIOL, ALIZARIN RED, CACODYLATE ION, ... | Authors: | James, L.C, Roversi, P, Tawfik, D. | Deposit date: | 2003-01-21 | Release date: | 2004-01-15 | Last modified: | 2013-10-30 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Antibody Multispecificity Mediated by Conformational Diversity Science, 299, 2003
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1OAU
| Fv Structure of the IgE SPE-7 in complex with DNP-Ser (immunising hapten) | Descriptor: | 2,4-DINITROPHENOL, IMIDAZOLE, IMMUNOGLOBULIN E, ... | Authors: | James, L.C, Roversi, P, Tawfik, D. | Deposit date: | 2003-01-21 | Release date: | 2004-01-15 | Last modified: | 2013-10-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Antibody Multispecificity Mediated by Conformational Diversity Science, 299, 2003
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1ZJM
| Human DNA Polymerase beta complexed with DNA containing an A-A mismatched primer terminus | Descriptor: | 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3', 5'-D(P*GP*TP*CP*GP*G)-3', DNA polymerase beta, ... | Authors: | Batra, V.K, Beard, W.A, Shock, D.D, Pedersen, L.C, Wilson, S.H. | Deposit date: | 2005-04-29 | Release date: | 2005-08-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. STRUCTURE, 13, 2005
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1YWR
| Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone Inhibitor | Descriptor: | 4-(4-FLUOROPHENYL)-1-METHYL-5-(2-{[(1S)-1-PHENYLETHYL]AMINO}PYRIMIDIN-4-YL)-2-PIPERIDIN-4-YL-1,2-DIHYDRO-3H-PYRAZOL-3-ONE, Mitogen-activated protein kinase 14 | Authors: | Golebiowski, A, Townes, J.A, Laufersweiler, M.J, Brugel, T.A, Clark, M.P, Clark, C.M, Djung, J.F, Laughlin, S.K, Sabat, M.P, Bookland, R.G, Vanrens, J.C, De, B, Hsieh, L.C, Janusz, M.J, Walter, R.L, Webster, M.E, Mekel, M.J. | Deposit date: | 2005-02-18 | Release date: | 2005-05-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The development of monocyclic pyrazolone based cytokine synthesis inhibitors. Bioorg.Med.Chem.Lett., 15, 2005
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1OAY
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1OCW
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1OAQ
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1ON8
| Crystal structure of mouse alpha-1,4-N-acetylhexosaminyltransferase (EXTL2) with UDP and GlcUAb(1-3)Galb(1-O)-naphthalenelmethanol an acceptor substrate analog | Descriptor: | 1,2-ETHANEDIOL, Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, MANGANESE (II) ION, ... | Authors: | Pedersen, L.C, Dong, J, Taniguchi, F, Kitagawa, H, Krahn, J.M, Pedersen, L.G, Sugahara, K, Negishi, M. | Deposit date: | 2003-02-27 | Release date: | 2003-04-22 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of an alpha-1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis J.Biol.Chem., 278, 2003
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1P4O
| Structure of Apo unactivated IGF-1R KInase domain at 1.5A resolution. | Descriptor: | Insulin-like growth factor I receptor protein | Authors: | Munshi, S, Kornienko, M, Hall, D.L, Darke, P.L, Waxman, L, Kuo, L.C. | Deposit date: | 2003-04-23 | Release date: | 2003-04-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution. Acta Crystallogr.,Sect.D, 59, 2003
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1OMX
| Crystal structure of mouse alpha-1,4-N-acetylhexosaminyltransferase (EXTL2) | Descriptor: | 1,2-ETHANEDIOL, Alpha-1,4-N-acetylhexosaminyltransferase EXTL2 | Authors: | Pedersen, L.C, Dong, J, Taniguchi, F, Kitagawa, H, Krahn, J.M, Pedersen, L.G, Sugahara, K, Negishi, M. | Deposit date: | 2003-02-26 | Release date: | 2003-04-22 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of an alpha-1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis J.Biol.Chem., 278, 2003
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1OMZ
| crystal structure of mouse alpha-1,4-N-acetylhexosaminyltransferase (EXTL2) in complex with UDPGalNAc | Descriptor: | 1,2-ETHANEDIOL, Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, MANGANESE (II) ION, ... | Authors: | Pedersen, L.C, Dong, J, Taniguchi, F, Kitagawa, H, Krahn, J.M, Pedersen, L.G, Sugahara, K, Negishi, M. | Deposit date: | 2003-02-26 | Release date: | 2003-04-22 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of an alpha-1,4-N-acetylhexosaminyltransferase (EXTL2),
a member of the exostosin gene family involved in heparan sulfate biosynthesis J.Biol.Chem., 278, 2003
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1OY1
| X-Ray Structure Of ElbB From E. Coli. Northeast Structural Genomics Research Consortium (Nesg) Target Er105 | Descriptor: | PUTATIVE sigma cross-reacting protein 27A | Authors: | Benach, J, Edstrom, W, Ma, L.C, Xiao, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2003-04-03 | Release date: | 2003-04-22 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | X-Ray Structure Of ElbB From E. Coli. Northeast Structural Genomics Research Consortium (Nesg) Target Er105 To be Published
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2AAK
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1ON6
| Crystal structure of mouse alpha-1,4-N-acetylhexosaminotransferase (EXTL2) in complex with UDPGlcNAc | Descriptor: | 1,2-ETHANEDIOL, Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, MANGANESE (II) ION, ... | Authors: | Pedersen, L.C, Dong, J, Taniguchi, F, Kitagawa, H, Krahn, J.M, Pedersen, L.G, Sugahara, K, Negishi, M. | Deposit date: | 2003-02-27 | Release date: | 2003-04-22 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of an alpha-1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis J.Biol.Chem., 278, 2003
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2AW2
| Crystal structure of the human BTLA-HVEM complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B and T lymphocyte attenuator, NICKEL (II) ION, ... | Authors: | Compaan, D.M, Gonzalez, L.C, Tom, I, Loyet, K.M, Eaton, D, Hymowitz, S.G. | Deposit date: | 2005-08-31 | Release date: | 2005-09-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Attenuating Lymphocyte Activity: the crystal structure of the BTLA-HVEM complex J.Biol.Chem., 280, 2005
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1OHQ
| Crystal structure of HEL4, a soluble human VH antibody domain resistant to aggregation | Descriptor: | IMMUNOGLOBULIN | Authors: | Jespers, L, Schon, O, James, L.C, Veprintsev, D, Winter, G. | Deposit date: | 2003-05-30 | Release date: | 2004-03-11 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of Hel4, a Soluble, Refoldable Human V(H) Single Domain with a Germ-Line Scaffold J.Mol.Biol., 337, 2004
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1PD1
| Crystal structure of the COPII coat subunit, Sec24, complexed with a peptide containing the DxE cargo sorting signal of yeast Sys1 protein | Descriptor: | DxE cargo sorting signal peptide of yeast Sys1 protein, Protein transport protein Sec24, ZINC ION | Authors: | Mossessova, E, Bickford, L.C, Goldberg, J. | Deposit date: | 2003-05-18 | Release date: | 2003-08-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | SNARE selectivity of the COPII coat. Cell(Cambridge,Mass.), 114, 2003
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1PD0
| Crystal structure of the COPII coat subunit, Sec24, complexed with a peptide from the SNARE protein Sed5 (yeast syntaxin-5) | Descriptor: | COPII-binding peptide of the integral membrane protein SED5, Protein transport protein Sec24, ZINC ION | Authors: | Mossessova, E, Bickford, L.C, Goldberg, J. | Deposit date: | 2003-05-18 | Release date: | 2003-08-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | SNARE selectivity of the COPII coat. Cell(Cambridge,Mass.), 114, 2003
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1PCX
| Crystal structure of the COPII coat subunit, Sec24, complexed with a peptide from the SNARE protein Bet1 | Descriptor: | COPII-binding peptide of the protein transport protein BET1, Protein transport protein Sec24, ZINC ION | Authors: | Mossessova, E, Bickford, L.C, Goldberg, J. | Deposit date: | 2003-05-18 | Release date: | 2003-08-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | SNARE selectivity of the COPII coat. Cell(Cambridge,Mass.), 114, 2003
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1PBW
| STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN | Descriptor: | PHOSPHATIDYLINOSITOL 3-KINASE | Authors: | Musacchio, A, Cantley, L.C, Harrison, S.C. | Deposit date: | 1996-10-17 | Release date: | 1997-03-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit. Proc.Natl.Acad.Sci.USA, 93, 1996
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2BCR
| DNA polymerase lambda in complex with a DNA duplex containing an unpaired Damp | Descriptor: | 1,2-ETHANEDIOL, 5'-D(*CP*AP*GP*TP*AP*CP*G)-3', 5'-D(*CP*GP*GP*CP*CP*GP*AP*TP*AP*CP*TP*G)-3', ... | Authors: | Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Pedersen, L.C, Kunkel, T.A. | Deposit date: | 2005-10-19 | Release date: | 2006-03-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase Cell(Cambridge,Mass.), 124, 2006
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2BCQ
| DNA polymerase lambda in complex with a DNA duplex containing an unpaired Dtmp | Descriptor: | 1,2-ETHANEDIOL, 5'-D(*CP*AP*GP*TP*AP*CP*G)-3', 5'-D(*CP*GP*GP*CP*CP*GP*TP*TP*AP*CP*TP*G)-3', ... | Authors: | Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Pedersen, L.C, Kunkel, T.A. | Deposit date: | 2005-10-19 | Release date: | 2006-03-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase Cell(Cambridge,Mass.), 124, 2006
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2B0F
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