9RS6
 
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9RS7
 | | Ypt7 in complex with its GEF Mon1-Ccz1 | | Descriptor: | CCZ1/INTU/HSP4 first Longin domain-containing protein, Rab small monomeric GTPase-like protein, Vacuolar fusion protein MON1 | | Authors: | Wilmes, S, Schaefer, J, Moeller, A, Kuemmel, D. | | Deposit date: | 2025-06-30 | | Release date: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Mechanistic Adaptation of the Metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
To Be Published
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9RS8
 | | human Fuzzy-Inturned | | Descriptor: | Protein fuzzy homolog, Protein inturned | | Authors: | Wilmes, S, Schaefer, J, Januliene, D, Moeller, A, Kuemmel, D. | | Deposit date: | 2025-06-30 | | Release date: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Mechanistic Adaptation of the Metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
To Be Published
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9RS9
 | | Rab23 in complex with Fuzzy-Inturned | | Descriptor: | Protein fuzzy homolog, Protein inturned, Ras-related protein Rab-23 | | Authors: | Wilmes, S, Schaefer, J, Januliene, D, Moeller, A, Kuemmel, D. | | Deposit date: | 2025-06-30 | | Release date: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Mechanistic Adaptation of the Metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
To Be Published
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8CCK
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8CCJ
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8CCM
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8CCL
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3RK3
 | | Truncated SNARE complex with complexin | | Descriptor: | Complexin-1, SNAP25, Syntaxin 1a, ... | | Authors: | Kuemmel, D, Reinisch, K.M. | | Deposit date: | 2011-04-17 | | Release date: | 2011-07-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Complexin cross-links prefusion SNAREs into a zigzag array.
Nat.Struct.Mol.Biol., 18, 2011
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3RL0
 | | Truncated SNARE complex with complexin (P1) | | Descriptor: | Complexin-1, Synaptosomal-associated protein 25, Syntaxin-1A, ... | | Authors: | Kuemmel, D, Reinisch, K.M. | | Deposit date: | 2011-04-19 | | Release date: | 2011-07-27 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Complexin cross-links prefusion SNAREs into a zigzag array.
Nat.Struct.Mol.Biol., 18, 2011
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3RK2
 | | Truncated SNARE complex | | Descriptor: | CALCIUM ION, Synaptosomal-associated protein 25, Syntaxin-1A, ... | | Authors: | Kuemmel, D, Reinisch, K.M. | | Deposit date: | 2011-04-17 | | Release date: | 2011-07-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Complexin cross-links prefusion SNAREs into a zigzag array.
Nat.Struct.Mol.Biol., 18, 2011
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9QWP
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8CPO
 | | Crystal structure of the PolB16_OarG intein variant S1A, N183A, C111A, C165A | | Descriptor: | PolB16 Intein Cys-less | | Authors: | Kattelmann, S, Pasch, T, Mootz, H.D, Kuemmel, D. | | Deposit date: | 2023-03-03 | | Release date: | 2023-05-17 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural and biochemical analysis of a novel atypically split intein reveals a conserved histidine specific to cysteine-less inteins.
Chem Sci, 14, 2023
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9HTH
 | | Crystal structure of the fused, cysteine-less Aes123 PolB1 split intein (with S1A, N159A mutations) | | Descriptor: | DNA-directed DNA polymerase | | Authors: | Fitzian, K, Yilmaz, Z, Humberg, C, Mootz, H.D, Kuemmel, D. | | Deposit date: | 2024-12-19 | | Release date: | 2025-05-07 | | Method: | X-RAY DIFFRACTION (1.378 Å) | | Cite: | A cysteine-less and ultra-fast split intein rationally engineered from being aggregation-prone to highly efficient in protein trans-splicing.
Nat Commun, 16, 2025
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7ZTY
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8C7G
 | | Drosophila melanogaster Rab7 GEF complex Mon1-Ccz1-Bulli | | Descriptor: | Caffeine, calcium, zinc sensitivity 1, ... | | Authors: | Schaefer, J, Herrmann, E, Kuemmel, D, Moeller, A. | | Deposit date: | 2023-01-15 | | Release date: | 2023-05-17 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of the metazoan Rab7 GEF complex Mon1-Ccz1-Bulli.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7P9E
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9IGQ
 | | Crystal structure of PPK2 class III from Erysipelotrichaceae bacterium in complex with AppCH2p and polyphosphate | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, BENZOIC ACID, GLYCEROL, ... | | Authors: | Rasche, R, Lawrence-Doerner, A.-M, Cornelissen, N.V, Kuemmel, D. | | Deposit date: | 2025-02-20 | | Release date: | 2025-07-23 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure-guided engineering of a polyphosphate kinase 2 class III from an Erysipelotrichaceae bacterium to produce base-modified purine nucleotides.
Rsc Chem Biol, 2025
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9IGR
 | | Crystal structure of PPK2 class III from Erysipelotrichaceae bacterium in complex with polyphosphate | | Descriptor: | BENZOIC ACID, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Rasche, R, Lawrence-Doerner, A.-M, Cornelissen, N.V, Kuemmel, D. | | Deposit date: | 2025-02-20 | | Release date: | 2025-07-23 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (2.311 Å) | | Cite: | Structure-guided engineering of a polyphosphate kinase 2 class III from an Erysipelotrichaceae bacterium to produce base-modified purine nucleotides.
Rsc Chem Biol, 2025
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9QU1
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7P84
 | | Crystal structure of L147A/I351A variant of S-adenosylmethionine synthetase from Methanocaldococcus jannaschii in complex with ONB-SAM (2-nitro benzyme S-adenosyl-methionine) | | Descriptor: | MAGNESIUM ION, S-adenosylmethionine synthase, TRIPHOSPHATE, ... | | Authors: | Herrmann, E, Peters, A, Cornelissen, N.V, Rentmeister, A, Kuemmel, D. | | Deposit date: | 2021-07-21 | | Release date: | 2021-11-17 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.054 Å) | | Cite: | Visible-Light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases.
Chembiochem, 23, 2022
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5LDD
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6ZGQ
 | | AceL NrdHF class 3 split intein GSH linked splice inactive variant - C124A, N146A | | Descriptor: | AceL NrdHF-1-1 Intein, IODIDE ION | | Authors: | Hoffmann, S, Mootz, H.D, Kuemmel, D, Singh, R. | | Deposit date: | 2020-06-19 | | Release date: | 2020-09-16 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Biochemical and Structural Characterization of an Unusual and Naturally Split Class 3 Intein.
Chembiochem, 22, 2021
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7ZU0
 | | HOPS tethering complex from yeast | | Descriptor: | E3 ubiquitin-protein ligase PEP5, Vacuolar membrane protein PEP3, Vacuolar morphogenesis protein 6, ... | | Authors: | Shvarev, D, Schoppe, J, Koenig, C, Perz, A, Fuellbrunn, N, Kiontke, S, Langemeyer, L, Januliene, D, Schnelle, K, Kuemmel, D, Froehlich, F, Moeller, A, Ungermann, C. | | Deposit date: | 2022-05-11 | | Release date: | 2022-09-28 | | Last modified: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery.
Elife, 11, 2022
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7P9D
 | | Crystal structure of Chlamydomonas reinhardtii NADPH Dependent Thioredoxin Reductase 1 domain | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Thioredoxin reductase | | Authors: | Singh, R.K, Marchetti, G.M, Hippler, M, Kuemmel, D. | | Deposit date: | 2021-07-27 | | Release date: | 2022-01-12 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structural analysis revealed a novel conformation of the NTRC reductase domain from Chlamydomonas reinhardtii.
J.Struct.Biol., 214, 2021
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