4P6I
 
 | | Crystal structure of the Cas1-Cas2 complex from Escherichia coli | | 分子名称: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2 | | 著者 | Nunez, J.K, Kranzusch, P.J, Noeske, J, Doudna, J.A. | | 登録日 | 2014-03-24 | | 公開日 | 2014-05-07 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity.
Nat.Struct.Mol.Biol., 21, 2014
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5UQD
 | | DPY-21 in complex with Fe(II) and alpha-Ketoglutarate | | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 2-OXOGLUTARIC ACID, DumPY: shorter than wild-type, ... | | 著者 | Brejc, K, Bian, Q, Uzawa, S, Wheeler, B.S, Anderson, E.C, King, D.S, Kranzusch, P.J, Preston, C.G, Meyer, B.J. | | 登録日 | 2017-02-07 | | 公開日 | 2017-09-13 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | | 主引用文献 | Dynamic Control of X Chromosome Conformation and Repression by a Histone H4K20 Demethylase.
Cell, 171, 2017
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5VGB
 | | Crystal structure of NmeCas9 HNH domain bound to anti-CRISPR AcrIIC1 | | 分子名称: | Anti-CRISPR protein (AcrIIC1), CRISPR-associated endonuclease Cas9, GLYCEROL, ... | | 著者 | Harrington, L.B, Doxzen, K.W, Ma, E, Knott, G.J, Kranzusch, P.J, Doudna, J.A. | | 登録日 | 2017-04-10 | | 公開日 | 2017-08-30 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.497 Å) | | 主引用文献 | A Broad-Spectrum Inhibitor of CRISPR-Cas9.
Cell, 170, 2017
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8DP6
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8DP7
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8EFN
 | | Structure of Sp-STING3 from Stylophora pistillata coral in complex with 3',3'-cGAMP | | 分子名称: | 1,2-ETHANEDIOL, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, Stimulator of interferon genes protein | | 著者 | Li, Y, Slavik, K.M, Morehouse, B.R, Mears, K, Kranzusch, P.J. | | 登録日 | 2022-09-08 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | cGLRs are a diverse family of pattern recognition receptors in innate immunity.
Cell, 186, 2023
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8EFM
 | | Structure of coral STING receptor from Stylophora pistillata in complex with 2',3'-cGAMP | | 分子名称: | SULFATE ION, Stimulator of interferon genes protein, cGAMP | | 著者 | Li, Y, Slavik, K.M, Morehouse, B.R, Mears, K, Kranzusch, P.J. | | 登録日 | 2022-09-08 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | cGLRs are a diverse family of pattern recognition receptors in innate immunity.
Cell, 186, 2023
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8FNU
 | | Structure of RdrA from Streptococcus suis RADAR defense system | | 分子名称: | KAP NTPase domain-containing protein | | 著者 | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | | 登録日 | 2022-12-28 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-03-15 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex.
Cell, 186, 2023
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8FNT
 | | Structure of RdrA from Escherichia coli RADAR defense system | | 分子名称: | Archaeal ATPase | | 著者 | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | | 登録日 | 2022-12-28 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-03-15 | | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | | 主引用文献 | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex.
Cell, 186, 2023
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8FNV
 | | Structure of RdrB from Escherichia coli RADAR defense system | | 分子名称: | Adenosine deaminase, ZINC ION | | 著者 | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | | 登録日 | 2022-12-28 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-03-15 | | 実験手法 | ELECTRON MICROSCOPY (2.11 Å) | | 主引用文献 | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex.
Cell, 186, 2023
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8FNW
 | | Structure of RdrA-RdrB complex from Escherichia coli RADAR defense system | | 分子名称: | Adenosine deaminase, Archaeal ATPase, ZINC ION | | 著者 | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | | 登録日 | 2022-12-28 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-03-15 | | 実験手法 | ELECTRON MICROSCOPY (6.73 Å) | | 主引用文献 | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex.
Cell, 186, 2023
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8SME
 | | Structure of SPO1 phage Tad2 in apo state | | 分子名称: | Gp34.65 | | 著者 | Lu, A, Yirmiya, E, Leavitt, A, Avraham, C, Osterman, I, Garb, J, Antine, S.P, Mooney, S.E, Hobbs, S.J, Amitai, G, Sorek, R, Kranzusch, P.J. | | 登録日 | 2023-04-26 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | Phages overcome bacterial immunity via diverse anti-defence proteins.
Nature, 625, 2024
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8SMG
 | | Structure of SPO1 phage Tad2 in complex with 1''-2' gcADPR | | 分子名称: | (1S,3R,4R,6R,9S,11R,14R,15S,16R,18R)-4-(6-amino-9H-purin-9-yl)-9,11,15,16,18-pentahydroxy-2,5,8,10,12,17-hexaoxa-9lambda~5~,11lambda~5~-diphosphatricyclo[12.2.1.1~3,6~]octadecane-9,11-dione, Gp34.65 | | 著者 | Lu, A, Yirmiya, E, Leavitt, A, Avraham, C, Osterman, I, Garb, J, Antine, S.P, Mooney, S.E, Hobbs, S.J, Amitai, G, Sorek, R, Kranzusch, P.J. | | 登録日 | 2023-04-26 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Phages overcome bacterial immunity via diverse anti-defence proteins.
Nature, 625, 2024
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8SM3
 | | Structure of Bacillus cereus VD045 Gabija GajA-GajB Complex | | 分子名称: | Endonuclease GajA, Gabija protein GajB, SULFATE ION | | 著者 | Antine, S.P, Mooney, S.E, Johnson, A.G, Kranzusch, P.J. | | 登録日 | 2023-04-25 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural basis of Gabija anti-phage defence and viral immune evasion.
Nature, 625, 2024
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8SMD
 | | Structure of Clostridium botulinum prophage Tad1 in complex with 1''-3' gcADPR | | 分子名称: | (2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione, ABC transporter ATPase | | 著者 | Lu, A, Yirmiya, E, Leavitt, A, Avraham, C, Osterman, I, Garb, J, Antine, S.P, Mooney, S.E, Hobbs, S.J, Amitai, G, Sorek, R, Kranzusch, P.J. | | 登録日 | 2023-04-26 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Phages overcome bacterial immunity via diverse anti-defence proteins.
Nature, 625, 2024
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8SMF
 | | Structure of SPO1 phage Tad2 in complex with 1''-3' gcADPR | | 分子名称: | (2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione, Gp34.65, MAGNESIUM ION | | 著者 | Lu, A, Yirmiya, E, Leavitt, A, Avraham, C, Osterman, I, Garb, J, Antine, S.P, Mooney, S.E, Hobbs, S.J, Amitai, G, Sorek, R, Kranzusch, P.J. | | 登録日 | 2023-04-26 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Phages overcome bacterial immunity via diverse anti-defence proteins.
Nature, 625, 2024
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8T9N
 | | Bacillus subtilis RsgI GGG mutant | | 分子名称: | Anti-sigma-I factor RsgI | | 著者 | Brogan, A.P, Habib, C, Hobbs, S.J, Kranzusch, P.J, Rudner, D.Z. | | 登録日 | 2023-06-24 | | 公開日 | 2023-09-20 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8SRZ
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8SS1
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8GBE
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7T26
 | | Structure of phage FBB1 anti-CBASS nuclease Acb1 in apo state | | 分子名称: | Acb1 | | 著者 | Hobbs, S.J, Wein, T, Lu, A, Morehouse, B.R, Schnabel, J, Sorek, R, Kranzusch, P.J. | | 登録日 | 2021-12-03 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | | 主引用文献 | Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Nature, 605, 2022
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7T28
 | | Structure of phage Bsp38 anti-Pycsar nuclease Apyc1 in apo state | | 分子名称: | Putative metal-dependent hydrolase, ZINC ION | | 著者 | Hobbs, S.J, Wein, T, Lu, A, Morehouse, B.R, Schnabel, J, Sorek, R, Kranzusch, P.J. | | 登録日 | 2021-12-03 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Nature, 605, 2022
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7T27
 | | Structure of phage FBB1 anti-CBASS nuclease Acb1-3'3'-cGAMP complex in post reaction state | | 分子名称: | Acb1, SULFATE ION, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-2-[[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-2-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl]oxy-sulfanyl-phosphoryl]oxymethyl]-4-oxidanyl-oxolan-3-yl]oxy-sulfanyl-phosphinic acid | | 著者 | Hobbs, S.J, Wein, T, Lu, A, Morehouse, B.R, Schnabel, J, Sorek, R, Kranzusch, P.J. | | 登録日 | 2021-12-03 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Nature, 605, 2022
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7TQN
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7TQO
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