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1LWR
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BU of 1lwr by Molmil
Solution structure of the NCAM fibronectin type III module 2
分子名称: Neural Cell Adhesion Molecule 1, 140 kDa isoform
著者Kiselyov, V.V, Skladchikova, G, Hinsby, A.M, Jensen, P.H, Kulahin, N, Pedersen, N, Tsetlin, V, Poulsen, F.M, Berezin, V, Bock, E.
登録日2002-06-03
公開日2003-06-03
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP
Structure, 11, 2003
2CKN
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BU of 2ckn by Molmil
NMR Structure of the First Ig Module of mouse FGFR1
分子名称: BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1
著者Kiselyov, V.V, Bock, E, Berezin, V, Poulsen, F.M.
登録日2006-04-20
公開日2006-05-31
最終更新日2020-01-15
実験手法SOLUTION NMR
主引用文献NMR Structure of the First Ig Module of Mouse Fgfr1.
Protein Sci., 15, 2006
1QZ1
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BU of 1qz1 by Molmil
Crystal Structure of the Ig 1-2-3 fragment of NCAM
分子名称: Neural cell adhesion molecule 1, 140 kDa isoform
著者Soroka, V, Kolkova, K, Kastrup, J.S, Diederichs, K, Breed, J, Kiselyov, V.V, Poulsen, F.M, Larsen, I.K, Welte, W, Berezin, V, Bock, E, Kasper, C.
登録日2003-09-15
公開日2003-11-04
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion
Structure, 11, 2003
8DI2
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BU of 8di2 by Molmil
Site 2 insulin receptor binding peptide IM459N21
分子名称: Site 2 binding peptide IM459N21
著者Lawrence, M.C, Hu, H, Martinez, F.J, Espinosa, J.F.
登録日2022-06-28
公開日2022-11-09
実験手法SOLUTION NMR
主引用文献Activation of the human insulin receptor by non-insulin-related peptides.
Nat Commun, 13, 2022
2WFU
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BU of 2wfu by Molmil
Crystal structure of DILP5 variant DB
分子名称: PROBABLE INSULIN-LIKE PEPTIDE 5 A CHAIN, PROBABLE INSULIN-LIKE PEPTIDE 5 B CHAIN
著者Kulahin, N, Schluckebier, G, Sajid, W, De Meyts, P.
登録日2009-04-15
公開日2010-05-26
最終更新日2012-04-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural and Biological Properties of the Drosophila Insulin-Like Peptide 5 Show Evolutionary Conservation.
J.Biol.Chem., 286, 2011
2WFV
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BU of 2wfv by Molmil
Crystal structure of DILP5 variant C4
分子名称: PROBABLE INSULIN-LIKE PEPTIDE 5 A CHAIN, PROBABLE INSULIN-LIKE PEPTIDE 5 B CHAIN
著者Kulahin, N, Schluckebier, G, Sajid, W, De Meyts, P.
登録日2009-04-15
公開日2010-05-26
最終更新日2012-04-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural and Biological Properties of the Drosophila Insulin-Like Peptide 5 Show Evolutionary Conservation.
J.Biol.Chem., 286, 2011
5U8Q
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BU of 5u8q by Molmil
Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-MALATE, ...
著者Lawrence, M, Xu, Y.
登録日2016-12-14
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.2710402 Å)
主引用文献How ligand binds to the type 1 insulin-like growth factor receptor.
Nat Commun, 9, 2018
5U8R
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BU of 5u8r by Molmil
Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-MALATE, ...
著者Lawrence, M, Xu, Y.
登録日2016-12-14
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.00001621 Å)
主引用文献How ligand binds to the type 1 insulin-like growth factor receptor.
Nat Commun, 9, 2018
7U6D
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BU of 7u6d by Molmil
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM459
分子名称: IM459, Isoform Short of Insulin receptor
著者Kirk, N.S, Lawrence, M.C.
登録日2022-03-03
公開日2022-10-05
実験手法ELECTRON MICROSCOPY (5.03 Å)
主引用文献Activation of the human insulin receptor by non-insulin-related peptides
Nat Commun, 13, 2022
7U6E
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BU of 7u6e by Molmil
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IM462, ...
著者Kirk, N.S, Lawrence, M.C.
登録日2022-03-03
公開日2022-10-05
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Activation of the human insulin receptor by non-insulin-related peptides
Nat Commun, 13, 2022
2NCM
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BU of 2ncm by Molmil
NEURAL CELL ADHESION MOLECULE, NMR, 20 STRUCTURES
分子名称: NEURAL CELL ADHESION MOLECULE
著者Thomsen, N.K, Poulsen, F.M.
登録日1996-12-16
公開日1997-03-12
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献The three-dimensional structure of the first domain of neural cell adhesion molecule.
Nat.Struct.Biol., 3, 1996
4PFC
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BU of 4pfc by Molmil
Crystal structure of insulin degrading enzyme complexed with inhibitor
分子名称: Insulin-degrading enzyme, ZINC ION, methyl [(2S)-2-(5-{5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamate
著者Wang, Y, Guo, S.
登録日2014-04-28
公開日2015-06-17
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015
4PF9
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BU of 4pf9 by Molmil
Crystal structure of insulin degrading enzyme complexed with inhibitor
分子名称: Insulin-degrading enzyme, ZINC ION, methyl [(2S)-2-[4-({5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}oxy)phenyl]-3-(quinolin-3-yl)propyl]carbamate
著者Wang, Y, Guo, S.
登録日2014-04-28
公開日2015-06-17
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015
4PES
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BU of 4pes by Molmil
Crystal structure of insulin degrading enzyme complexed with inhibitor tert-butyl [(2S)-2-(2,5-difluorophenyl)-3-(quinolin-3-yl)propyl]carbamate
分子名称: Ala-Ala-Ala, Insulin-degrading enzyme, ZINC ION, ...
著者Wang, Y, Guo, S.
登録日2014-04-24
公開日2015-06-17
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Crystal structure of IDE complexed with an inhibitor
To Be Published
4PF7
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BU of 4pf7 by Molmil
Crystal structure of insulin degrading enzyme complexed with inhibitor
分子名称: (2S)-2-amino-N-{(1S)-1-cyclohexyl-2-[(4-methylphenyl)amino]-2-oxoethyl}-4-(methylselanyl)butanamide, Insulin-degrading enzyme, ZINC ION
著者Wang, Y, Guo, S.
登録日2014-04-28
公開日2015-06-17
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015

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