6L4L
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7EIV
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![BU of 7eiv by Molmil](/molmil-images/mine/7eiv) | heterotetrameric glycyl-tRNA synthetase from Escherichia coli | Descriptor: | GLYCINE, Glycine--tRNA ligase alpha subunit, Glycine--tRNA ligase beta subunit, ... | Authors: | Ju, Y, Zhou, H. | Deposit date: | 2021-03-31 | Release date: | 2021-08-11 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | X-shaped structure of bacterial heterotetrameric tRNA synthetase suggests cryptic prokaryote functions and a rationale for synthetase classifications. Nucleic Acids Res., 49, 2021
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5HXW
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![BU of 5hxw by Molmil](/molmil-images/mine/5hxw) | L-amino acid deaminase from Proteus vulgaris | Descriptor: | CETYL-TRIMETHYL-AMMONIUM, FLAVIN-ADENINE DINUCLEOTIDE, L-amino acid deaminase | Authors: | Zhou, H, Ju, Y, Niu, L, Teng, M. | Deposit date: | 2016-01-31 | Release date: | 2016-08-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Crystal structure of a membrane-bound l-amino acid deaminase from Proteus vulgaris J.Struct.Biol., 195, 2016
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5I39
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![BU of 5i39 by Molmil](/molmil-images/mine/5i39) | High resolution structure of L-amino acid deaminase from Proteus vulgaris with the deletion of the specific insertion sequence | Descriptor: | 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, L-amino acid deaminase | Authors: | Zhou, H, Ju, Y, Niu, L, Teng, M. | Deposit date: | 2016-02-10 | Release date: | 2016-08-03 | Last modified: | 2016-08-24 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Crystal structure of a membrane-bound l-amino acid deaminase from Proteus vulgaris J.Struct.Biol., 195, 2016
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6L3X
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![BU of 6l3x by Molmil](/molmil-images/mine/6l3x) | Discovery of novel peptidomimetic boronate ClpP inhibitors with noncanonical enzyme mechanism as potent virulence blockers in vitro and in vivo | Descriptor: | ATP-dependent Clp protease proteolytic subunit, [(1~{R})-1-[[(2~{S})-2-[[2,5-bis(chloranyl)phenyl]carbonylamino]-3-(1~{H}-indol-3-yl)propanoyl]amino]-3-methyl-butyl]boronic acid | Authors: | Luo, Y.F, Bao, R, Ju, Y, He, L.H. | Deposit date: | 2019-10-15 | Release date: | 2020-08-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3054 Å) | Cite: | Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockersin Vitroandin Vivo. J.Med.Chem., 63, 2020
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6L40
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![BU of 6l40 by Molmil](/molmil-images/mine/6l40) | Discovery of novel peptidomimetic boronate ClpP inhibitors with noncanonical enzyme mechanism as potent virulence blockers in vitro and in vivo | Descriptor: | ATP-dependent Clp protease proteolytic subunit, [(1S)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazin-2-ylcarbonylamino)propanoyl]amino]butyl]boronic acid | Authors: | Luo, Y.F, Bao, R, Ju, Y, He, L.H. | Deposit date: | 2019-10-15 | Release date: | 2020-07-08 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.209 Å) | Cite: | Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockersin Vitroandin Vivo. J.Med.Chem., 63, 2020
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7YSE
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![BU of 7yse by Molmil](/molmil-images/mine/7yse) | Crystal structure of E. coli heterotetrameric GlyRS in complex with tRNA | Descriptor: | Glycine--tRNA ligase alpha subunit, Glycine--tRNA ligase beta subunit, MAGNESIUM ION, ... | Authors: | Han, L, Ju, Y, Zhou, H. | Deposit date: | 2022-08-12 | Release date: | 2023-02-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.907 Å) | Cite: | The binding mode of orphan glycyl-tRNA synthetase with tRNA supports the synthetase classification and reveals large domain movements. Sci Adv, 9, 2023
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6BNH
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![BU of 6bnh by Molmil](/molmil-images/mine/6bnh) | Solution NMR structures of BRD4 ET domain with JMJD6 peptide | Descriptor: | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, Bromodomain-containing protein 4 | Authors: | Konuma, T, Yu, D, Zhao, C, Ju, Y, Sharma, R, Ren, C, Zhang, Q, Zhou, M.-M, Zeng, L. | Deposit date: | 2017-11-16 | Release date: | 2017-12-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4. Sci Rep, 7, 2017
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7CBB
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6JIS
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![BU of 6jis by Molmil](/molmil-images/mine/6jis) | Crystal structure of the histidine racemase CntK in cobalt and nickel transporter system of staphylococcus aureus | Descriptor: | 1,2-ETHANEDIOL, CESIUM ION, CHLORIDE ION, ... | Authors: | Luo, S, Ju, Y, Zhou, H. | Deposit date: | 2019-02-23 | Release date: | 2019-10-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Crystal structure of CntK, the cofactor-independent histidine racemase in staphylopine-mediated metal acquisition of Staphylococcus aureus. Int.J.Biol.Macromol., 135, 2019
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6JIW
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![BU of 6jiw by Molmil](/molmil-images/mine/6jiw) | Crystal structure of S. aureus CntK with C72S mutation | Descriptor: | 1,2-ETHANEDIOL, Diaminopimelate epimerase, SULFATE ION | Authors: | Luo, S, Ju, Y, Zhou, H. | Deposit date: | 2019-02-23 | Release date: | 2019-10-16 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Crystal structure of CntK, the cofactor-independent histidine racemase in staphylopine-mediated metal acquisition of Staphylococcus aureus. Int.J.Biol.Macromol., 135, 2019
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6KNI
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6KNH
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![BU of 6knh by Molmil](/molmil-images/mine/6knh) | Crystal structure of SbnH in complex with citrate, a PLP-dependent decarboxylase in Staphyloferrin B biothesynthesis | Descriptor: | CITRIC ACID, PHOSPHATE ION, Probable diaminopimelate decarboxylase protein | Authors: | Tang, J, Ju, Y, Zhou, H. | Deposit date: | 2019-08-05 | Release date: | 2019-11-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structural Insights into Substrate Recognition and Activity Regulation of the Key Decarboxylase SbnH in Staphyloferrin B Biosynthesis. J.Mol.Biol., 431, 2019
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6KNK
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![BU of 6knk by Molmil](/molmil-images/mine/6knk) | Crystal structure of SbnH in complex with citryl-diaminoethane | Descriptor: | (2S)-2-{2-[(2-AMINOETHYL)AMINO]-2-OXOETHYL}-2-HYDROXYBUTANEDIOIC ACID, (2~{S})-2-[2-[2-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]ethylamino]-2-oxidanylidene-ethyl]-2-oxidanyl-butanedioic acid, PHOSPHATE ION, ... | Authors: | Tang, J, Ju, Y, Zhou, H. | Deposit date: | 2019-08-05 | Release date: | 2019-11-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Insights into Substrate Recognition and Activity Regulation of the Key Decarboxylase SbnH in Staphyloferrin B Biosynthesis. J.Mol.Biol., 431, 2019
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8I60
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6L2Q
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![BU of 6l2q by Molmil](/molmil-images/mine/6l2q) | Threonyl-tRNA synthetase from Salmonella enterica in complex with an inhibitor | Descriptor: | (2S,3R)-2-azanyl-N-[(E)-4-[6,7-bis(chloranyl)-4-oxidanylidene-quinazolin-3-yl]but-2-enyl]-3-oxidanyl-butanamide, 1,2-ETHANEDIOL, Threonine--tRNA ligase, ... | Authors: | Guo, J, Chen, B, Zhou, H. | Deposit date: | 2019-10-05 | Release date: | 2020-01-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping. Eur.J.Med.Chem., 187, 2019
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5ULA
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7DOR
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![BU of 7dor by Molmil](/molmil-images/mine/7dor) | E. coli GyrB ATPase domain in complex with 4-nitropheno | Descriptor: | 1H-benzimidazol-2-amine, DNA gyrase subunit B, P-NITROPHENOL, ... | Authors: | Yu, Y, Zhou, H. | Deposit date: | 2020-12-16 | Release date: | 2021-10-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Identification of new building blocks by fragment screening for discovering GyrB inhibitors. Bioorg.Chem., 114, 2021
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7DPR
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7DPS
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7DQH
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![BU of 7dqh by Molmil](/molmil-images/mine/7dqh) | E. coli GyrB ATPase domain in complex with 2-hydroxybenzamide | Descriptor: | 1H-benzimidazol-2-amine, DNA gyrase subunit B, PHOSPHATE ION, ... | Authors: | Yu, Y, Zhou, H. | Deposit date: | 2020-12-23 | Release date: | 2021-10-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Identification of new building blocks by fragment screening for discovering GyrB inhibitors. Bioorg.Chem., 114, 2021
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7DQI
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![BU of 7dqi by Molmil](/molmil-images/mine/7dqi) | E. coli GyrB ATPase domain in complex with Esculetin | Descriptor: | 1H-benzimidazol-2-amine, 6,7-bis(oxidanyl)chromen-2-one, DNA gyrase subunit B, ... | Authors: | Yu, Y, Zhou, H. | Deposit date: | 2020-12-23 | Release date: | 2021-10-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Identification of new building blocks by fragment screening for discovering GyrB inhibitors. Bioorg.Chem., 114, 2021
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7DQJ
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![BU of 7dqj by Molmil](/molmil-images/mine/7dqj) | E. coli GyrB ATPase domain in complex with 3,4-Dihydroxyacetophenone | Descriptor: | 1-[3,4-bis(oxidanyl)phenyl]ethanone, 1H-benzimidazol-2-amine, DNA gyrase subunit B, ... | Authors: | Yu, Y, Zhou, H. | Deposit date: | 2020-12-24 | Release date: | 2021-10-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Identification of new building blocks by fragment screening for discovering GyrB inhibitors. Bioorg.Chem., 114, 2021
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7DQF
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7DQU
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![BU of 7dqu by Molmil](/molmil-images/mine/7dqu) | E. coli GyrB ATPase domain in complex with methyl 4-hydroxybenzoate | Descriptor: | 1H-benzimidazol-2-amine, 4-HYDROXY-BENZOIC ACID METHYL ESTER, DNA gyrase subunit B, ... | Authors: | Yu, Y, Zhou, H. | Deposit date: | 2020-12-24 | Release date: | 2021-10-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Identification of new building blocks by fragment screening for discovering GyrB inhibitors. Bioorg.Chem., 114, 2021
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