9K8Q
 
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9K8R
 | | Structure of Promiscuous short chain dehydrogenase Spm14 in complex with NADPH | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Spm14 | | Authors: | Jing, L.Q, Peng, M, Chen, Y.Y, Ju, J.H, Wu, D.L. | | Deposit date: | 2024-10-24 | | Release date: | 2025-02-12 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Biosynthesis of Spiromarmycin Reveals the Unusual Formation of Benzopyran and the Mechanistic Insight of a Promiscuous Short Chain reductase Spm14
to be published
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2M0U
 | | Complex structure of C-terminal CFTR peptide and extended PDZ1 domain from NHERF1 | | Descriptor: | C-terminal CFTR peptide, Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | | Authors: | Bhattacharya, S, Ju, J.H, Cowburn, D, Bu, Z. | | Deposit date: | 2012-11-06 | | Release date: | 2013-04-24 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Ligand-Induced Dynamic Changes in Extended PDZ Domains from NHERF1.
J.Mol.Biol., 425, 2013
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2M0V
 | | Complex structure of C-terminal CFTR peptide and extended PDZ2 domain from NHERF1 | | Descriptor: | C-terminal CFTR peptide, Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | | Authors: | Bhattacharya, S, Ju, J.H, Cowburn, D, Bu, Z. | | Deposit date: | 2012-11-06 | | Release date: | 2013-04-24 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Ligand-Induced Dynamic Changes in Extended PDZ Domains from NHERF1.
J.Mol.Biol., 425, 2013
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2M0T
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8V3A
 | | Crystal structure of KRAS-G12C (GDP-bound) in complex with BBO-8520 | | Descriptor: | BBO-8520 (bound form), GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Chan, A.H, Bratcher, D.R, Simanshu, D.K. | | Deposit date: | 2023-11-27 | | Release date: | 2024-12-18 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C.
Cancer Discov, 15, 2025
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8V39
 | | Crystal structure of active KRAS-G12C (GMPPNP-bound) in complex with BBO-8520 | | Descriptor: | BBO-8520 (bound form), GTPase KRas, MAGNESIUM ION, ... | | Authors: | Chan, A.H, Ashraf, M, Dharmaiah, S, Simanshu, D.K. | | Deposit date: | 2023-11-27 | | Release date: | 2024-12-18 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C.
Cancer Discov, 15, 2025
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7YUA
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7YV0
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