9K8R

Structure of Promiscuous short chain dehydrogenase Spm14 in complex with NADPH

Summary for 9K8R

• Entry DOI: 10.2210/pdb9k8r/pdb
• Descriptor: Spm14, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL (3 entities in total)
• Functional Keywords: short chain dehydrogenase, coenzyme, nadph, biosynthetic protein
• Biological source: Spiromastix sp. SCSIO F190
• Total number of polymer chains: 2
• Total formula weight: 63485.73

Authors

Jing, L.Q.,Peng, M.,Chen, Y.Y.,Ju, J.H.,Wu, D.L. (deposition date: 2024-10-24, release date: 2025-02-12, Last modification date: 2025-09-03)

• Primary citation: Chen, Y.,Jing, L.,Peng, M.,Cai, C.,Shi, J.,Ge, W.,Liu, Y.,Shang, Z.,Ma, J.,Wu, D.,Ju, J.; Enzymatic Insights into the Unusual Formation of Benzolactone and Benzopyran in the Biosynthesis of Spiromarmycin; Acs Catalysis, 15:2809-2821, 2025; DOI: 10.1021/acscatal.4c07664

Experimental method

X-RAY DIFFRACTION (3.1 Å)