5BJO
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![BU of 5bjo by Molmil](/molmil-images/mine/5bjo) | Crystal structure of the Corn RNA aptamer in complex with DFHO, site-specific 5-iodo-U | Descriptor: | (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Warner, K.D, Song, W, Filonov, G.S, Jaffrey, S.R, Ferre-D'Amare, A.R. | Deposit date: | 2016-08-21 | Release date: | 2017-09-27 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | A homodimer interface without base pairs in an RNA mimic of red fluorescent protein. Nat. Chem. Biol., 13, 2017
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5BJP
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![BU of 5bjp by Molmil](/molmil-images/mine/5bjp) | Crystal structure of the Corn RNA aptamer in complex with DFHO, iridium hexammine soak | Descriptor: | (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, DIMETHYL SULFOXIDE, IRIDIUM ION, ... | Authors: | Warner, K.D, Song, W, Filonov, G.S, Jaffrey, S.R, Ferre-D'Amare, A.R. | Deposit date: | 2016-08-21 | Release date: | 2017-09-27 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | A homodimer interface without base pairs in an RNA mimic of red fluorescent protein. Nat. Chem. Biol., 13, 2017
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4TS2
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![BU of 4ts2 by Molmil](/molmil-images/mine/4ts2) | Crystal structure of the Spinach RNA aptamer in complex with DFHBI, magnesium ions | Descriptor: | (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Warner, K.D, Chen, M.C, Song, W, Strack, R.L, Thorn, A, Jaffrey, S.R, Ferre-D'Amare, A.R. | Deposit date: | 2014-06-18 | Release date: | 2014-07-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.884 Å) | Cite: | Structural basis for activity of highly efficient RNA mimics of green fluorescent protein. Nat.Struct.Mol.Biol., 21, 2014
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4TS0
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![BU of 4ts0 by Molmil](/molmil-images/mine/4ts0) | Crystal structure of the Spinach RNA aptamer in complex with DFHBI, barium ions | Descriptor: | (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one, BARIUM ION, POTASSIUM ION, ... | Authors: | Warner, K.D, Chen, M.C, Song, W, Strack, R.L, Thorn, A, Jaffrey, S.R, Ferre-D'Amare, A.R. | Deposit date: | 2014-06-18 | Release date: | 2014-07-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for activity of highly efficient RNA mimics of green fluorescent protein. Nat.Struct.Mol.Biol., 21, 2014
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5WWF
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![BU of 5wwf by Molmil](/molmil-images/mine/5wwf) | Crystal structure of hnRNPA2B1 in complex with RNA | Descriptor: | Heterogeneous nuclear ribonucleoproteins A2/B1, RNA | Authors: | Wu, B.X, Su, S.C, Ma, J.B. | Deposit date: | 2017-01-01 | Release date: | 2018-01-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1. Nat Commun, 9, 2018
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6H2V
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![BU of 6h2v by Molmil](/molmil-images/mine/6h2v) | Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA m6A1832 methyltransferase at 2.5A resolution | Descriptor: | 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, DI(HYDROXYETHYL)ETHER, ... | Authors: | van Tran, N, Graille, M. | Deposit date: | 2018-07-16 | Release date: | 2019-07-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. Nucleic Acids Res., 47, 2019
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6H2U
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![BU of 6h2u by Molmil](/molmil-images/mine/6h2u) | Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA m6A1832 methyltransferase at 1.6A resolution | Descriptor: | 1,2-ETHANEDIOL, Methyltransferase-like protein 5, Multifunctional methyltransferase subunit TRM112-like protein, ... | Authors: | van Tran, N, Graille, M. | Deposit date: | 2018-07-16 | Release date: | 2019-07-31 | Last modified: | 2019-09-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. Nucleic Acids Res., 47, 2019
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5EN1
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![BU of 5en1 by Molmil](/molmil-images/mine/5en1) | Crystal structure of hnRNPA2B1 in complex with RNA | Descriptor: | Heterogeneous nuclear ribonucleoproteins A2/B1, RNA (5'-R(*AP*GP*GP*AP*CP*UP*G)-3') | Authors: | Wu, B.X, Su, S.C, Ma, J.B. | Deposit date: | 2015-11-09 | Release date: | 2016-11-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1 Nat Commun, 2018
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5HO4
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![BU of 5ho4 by Molmil](/molmil-images/mine/5ho4) | Crystal structure of hnRNPA2B1 in complex with 10-mer RNA | Descriptor: | Heterogeneous nuclear ribonucleoproteins A2/B1, RNA (5'-R(*AP*AP*GP*GP*AP*CP*UP*AP*GP*C)-3') | Authors: | Wu, B.X, Su, S.C, Gan, J.H, Ma, J.B. | Deposit date: | 2016-01-19 | Release date: | 2017-02-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1. Nat Commun, 9, 2018
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5WWE
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![BU of 5wwe by Molmil](/molmil-images/mine/5wwe) | Crystal structure of hnRNPA2B1 in complex with RNA | Descriptor: | Heterogeneous nuclear ribonucleoproteins A2/B1, RNA (5'-R(*AP*GP*GP*GP*AP*CP*UP*AP*GP*A)-3') | Authors: | Wu, B.X, Su, S.C, Ma, J.B. | Deposit date: | 2017-01-01 | Release date: | 2018-01-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1. Nat Commun, 9, 2018
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5WWG
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![BU of 5wwg by Molmil](/molmil-images/mine/5wwg) | Crystal structure of hnRNPA2B1 in complex with AAGGACUUGC | Descriptor: | Heterogeneous nuclear ribonucleoproteins A2/B1, RNA (5'-R(*AP*AP*GP*GP*AP*CP*UP*U)-3') | Authors: | Wu, B.X, Su, S.C, Ma, J.B. | Deposit date: | 2017-01-01 | Release date: | 2018-01-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1. Nat Commun, 9, 2018
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7PCU
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![BU of 7pcu by Molmil](/molmil-images/mine/7pcu) | Crystal structure of YTHDF1 YTH domain in complex with ebselen | Descriptor: | N-phenyl-2-selanylbenzamide, YTH domain-containing family protein 1 | Authors: | Dalle Vedove, A, Cazzanelli, G, Quattrone, A, Provenzani, A, Lolli, G. | Deposit date: | 2021-08-04 | Release date: | 2022-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6 -Methyladenosine-Modified RNAs. Acs Pharmacol Transl Sci, 5, 2022
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7QKN
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![BU of 7qkn by Molmil](/molmil-images/mine/7qkn) | Crystal structure of YTHDF1 YTH domain in complex with the ebsulfur derivative compound 7 | Descriptor: | 1,2-ETHANEDIOL, THIOCYANATE ION, YTH domain-containing family protein 1, ... | Authors: | Dalle Vedove, A, Cazzanelli, G, Quattrone, A, Provenzani, A, Lolli, G. | Deposit date: | 2021-12-18 | Release date: | 2022-11-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6 -Methyladenosine-Modified RNAs. Acs Pharmacol Transl Sci, 5, 2022
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7QL7
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![BU of 7ql7 by Molmil](/molmil-images/mine/7ql7) | Crystal structure of YTHDF1 YTH domain in complex with the ebsulfur derivative compound 9 | Descriptor: | 1,2-ETHANEDIOL, THIOCYANATE ION, YTH domain-containing family protein 1, ... | Authors: | Dalle Vedove, A, Cazzanelli, G, Quattrone, A, Provenzani, A, Lolli, G. | Deposit date: | 2021-12-19 | Release date: | 2022-11-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6 -Methyladenosine-Modified RNAs. Acs Pharmacol Transl Sci, 5, 2022
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7KVV
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![BU of 7kvv by Molmil](/molmil-images/mine/7kvv) | Crystal structure of Squash RNA aptamer in complex with DFHBI-1T | Descriptor: | (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, MAGNESIUM ION, Squash RNA aptamer bound to DFHO | Authors: | Truong, L, Ferre-D'Amare, A.R. | Deposit date: | 2020-11-28 | Release date: | 2022-01-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | The fluorescent aptamer Squash extensively repurposes the adenine riboswitch fold. Nat.Chem.Biol., 18, 2022
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7KVT
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![BU of 7kvt by Molmil](/molmil-images/mine/7kvt) | Crystal structure of Squash RNA aptamer in complex with DFHBI-1T with iridium (III) ions | Descriptor: | (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2-methyl-3-(2,2,2-trifluoroethyl)-3,5-dihydro-4H-imidazol-4-one, IRIDIUM HEXAMMINE ION, MAGNESIUM ION, ... | Authors: | Truong, L, Ferre-D'Amare, A.R. | Deposit date: | 2020-11-28 | Release date: | 2022-01-19 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | The fluorescent aptamer Squash extensively repurposes the adenine riboswitch fold. Nat.Chem.Biol., 18, 2022
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7KVU
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![BU of 7kvu by Molmil](/molmil-images/mine/7kvu) | Crystal structure of Squash RNA aptamer in complex with DFHBI-1T | Descriptor: | (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2-methyl-3-(2,2,2-trifluoroethyl)-3,5-dihydro-4H-imidazol-4-one, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Truong, L, Ferre-D'Amare, A.R. | Deposit date: | 2020-11-28 | Release date: | 2022-01-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | The fluorescent aptamer Squash extensively repurposes the adenine riboswitch fold. Nat.Chem.Biol., 18, 2022
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1CMI
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![BU of 1cmi by Molmil](/molmil-images/mine/1cmi) | STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE | Descriptor: | Dynein light chain 1, cytoplasmic, Nitric oxide synthase 1 | Authors: | Liang, J, Guo, W, Jaffery, S, Snyder, S, Clardy, J. | Deposit date: | 1999-05-06 | Release date: | 2000-02-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the PIN/LC8 dimer with a bound peptide. Nat.Struct.Biol., 6, 1999
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8EYW
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![BU of 8eyw by Molmil](/molmil-images/mine/8eyw) | Beetroot dimer bound to ThT | Descriptor: | 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium, POTASSIUM ION, RNA (49-MER) | Authors: | Passalacqua, L.F.M, Ferre-D'Amare, A.R. | Deposit date: | 2022-10-28 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture. Nat Commun, 14, 2023
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8EYU
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![BU of 8eyu by Molmil](/molmil-images/mine/8eyu) | Structure of Beetroot dimer bound to DFAME | Descriptor: | POTASSIUM ION, RNA (49-MER), methyl (2E)-3-{(4Z)-4-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl}prop-2-enoate | Authors: | Passalacqua, L.F.M, Ferre-D'Amare, A.R. | Deposit date: | 2022-10-28 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture. Nat Commun, 14, 2023
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8EYV
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![BU of 8eyv by Molmil](/molmil-images/mine/8eyv) | Structure of Beetroot dimer bound to DFHO | Descriptor: | (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, POTASSIUM ION, RNA (45-MER) | Authors: | Passalacqua, L.F.M, Ferre-D'Amare, A.R. | Deposit date: | 2022-10-28 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture. Nat Commun, 14, 2023
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8F0N
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![BU of 8f0n by Molmil](/molmil-images/mine/8f0n) | Wobble Beetroot (A16U-U38G) dimer bound to DFHO | Descriptor: | (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, POTASSIUM ION, RNA (49-MER) | Authors: | Passalacqua, L.F.M, Ferre-D'Amare, A.R. | Deposit date: | 2022-11-03 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture. Nat Commun, 14, 2023
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8FI8
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![BU of 8fi8 by Molmil](/molmil-images/mine/8fi8) | |
8FHZ
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![BU of 8fhz by Molmil](/molmil-images/mine/8fhz) | Structure of Lettuce aptamer bound to DFHO | Descriptor: | (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, Lettuce DNA aptamer, MAGNESIUM ION, ... | Authors: | Passalacqua, L.F.M, Ferre-D'Amare, A.R. | Deposit date: | 2022-12-15 | Release date: | 2023-05-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Intricate 3D architecture of a DNA mimic of GFP. Nature, 618, 2023
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8FHV
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![BU of 8fhv by Molmil](/molmil-images/mine/8fhv) | Structure of Lettuce aptamer bound to DFHBI-1T with thallium I ions | Descriptor: | (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2-methyl-3-(2,2,2-trifluoroethyl)-3,5-dihydro-4H-imidazol-4-one, Lettuce DNA aptamer, MAGNESIUM ION, ... | Authors: | Passalacqua, L.F.M, Ferre-D'Amare, A.R. | Deposit date: | 2022-12-15 | Release date: | 2023-05-10 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Intricate 3D architecture of a DNA mimic of GFP. Nature, 618, 2023
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