6HVM
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6HVL
| CdaA complex with c-di-AMP and AMP | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, ADENOSINE MONOPHOSPHATE, COBALT (II) ION, ... | 著者 | Heidemann, J.L, Neumann, P, Ficner, R. | 登録日 | 2018-10-11 | 公開日 | 2019-06-05 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structures of the c-di-AMP-synthesizing enzyme CdaA. J.Biol.Chem., 294, 2019
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1L7F
| Crystal structure of influenza virus neuraminidase in complex with BCX-1812 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID, ... | 著者 | Smith, B.J, McKimm-Breshkin, J.L, McDonald, M, Fernley, R.T, Varghese, J.N, Colman, P.M. | 登録日 | 2002-03-15 | 公開日 | 2002-05-29 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural studies of the resistance of influenza virus neuramindase to inhibitors. J.Med.Chem., 45, 2002
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6I0M
| Structure of human IMP dehydrogenase, isoform 2, bound to GDP | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, Inosine-5'-monophosphate dehydrogenase 2, ... | 著者 | Buey, R.M, Fernandez-Justel, D, Revuelta, J.L. | 登録日 | 2018-10-26 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.567 Å) | 主引用文献 | A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. J. Mol. Biol., 431, 2019
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6I0O
| Structure of human IMP dehydrogenase, isoform 2, bound to GTP | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase 2, SULFATE ION | 著者 | Buey, R.M, Fernandez-Justel, D, Revuelta, J.L. | 登録日 | 2018-10-26 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.623 Å) | 主引用文献 | A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. J. Mol. Biol., 431, 2019
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6I3V
| x-ray structure of the human mitochondrial PRELID1 in complex with TRIAP1 | 分子名称: | CHLORIDE ION, MYRISTIC ACID, PRELI domain-containing protein 1, ... | 著者 | Berry, J.L, Miliara, X, Morgan, R.M.L, Matthews, S.J. | 登録日 | 2018-11-07 | 公開日 | 2019-03-20 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins. Nat Commun, 10, 2019
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6I2O
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6I2T
| CryoEM reconstruction of full-length, fully-glycosylated human butyrylcholinesterase tetramer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cholinesterase, lamellipodin-derived polyproline peptide | 著者 | Leung, M.R, van Bezouwen, L.S, Schopfer, L.M, Sussman, J.L, Silman, I, Lockridge, O, Zeev-Ben-Mordehai, T. | 登録日 | 2018-11-01 | 公開日 | 2018-12-19 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | 主引用文献 | Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1OLS
| Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase | 分子名称: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, GLYCEROL, ... | 著者 | Wynn, R.M, Machius, M, Chuang, J.L, Li, J, Tomchick, D.R, Chuang, D.T. | 登録日 | 2003-08-12 | 公開日 | 2003-08-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Roles of His291-Alpha and His146-Beta' in the Reductive Acylation Reaction Catalyzed by Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site. J.Biol.Chem., 278, 2003
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1OLU
| Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase | 分子名称: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, GLYCEROL, ... | 著者 | Wynn, R.M, Machius, M, Chuang, J.L, Li, J, Tomchick, D.R, Chuang, D.T. | 登録日 | 2003-08-15 | 公開日 | 2003-08-28 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Roles of His291-Alpha and His146-Beta' in the Reductive Acylation Reaction Catalyzed by Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site. J.Biol.Chem., 278, 2003
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1OLX
| Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase | 分子名称: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, GLYCEROL, ... | 著者 | Wynn, R.M, Machius, M, Chuang, J.L, Li, J, Tomchick, D.R, Chuang, D.T. | 登録日 | 2003-08-18 | 公開日 | 2003-08-28 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Roles of His291-Alpha and His146-Beta' in the Reductive Acylation Reaction Catalyzed by Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site. J.Biol.Chem., 278, 2003
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2BRZ
| SOLUTION NMR STRUCTURE OF THE SWEET PROTEIN BRAZZEIN, MINIMIZED AVERAGE STRUCTURE | 分子名称: | BRAZZEIN | 著者 | Caldwell, J.E, Abildgaard, F, Dzakula, Z, Ming, D, Hellekant, G, Markley, J.L. | 登録日 | 1998-04-30 | 公開日 | 1998-07-01 | 最終更新日 | 2019-12-25 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the thermostable sweet-tasting protein brazzein. Nat.Struct.Biol., 5, 1998
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2BYV
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2DFP
| X-RAY STRUCTURE OF AGED DI-ISOPROPYL-PHOSPHORO-FLUORIDATE (DFP) BOUND TO ACETYLCHOLINESTERASE | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kryger, G, Millard, C.B, Silman, I, Sussman, J.L. | 登録日 | 1998-12-07 | 公開日 | 1999-06-28 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level. Biochemistry, 38, 1999
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2F3Z
| Calmodulin/IQ-AA domain complex | 分子名称: | CALCIUM ION, Calmodulin, Voltage-dependent L-type calcium channel alpha-1C subunit | 著者 | Fallon, J.L, Quiocho, F.A. | 登録日 | 2005-11-22 | 公開日 | 2005-12-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of Calmodulin Bound to the Hydrophobic IQ Domain of the Cardiac Ca(v)1.2 Calcium Channel. Structure, 13, 2005
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2F3Y
| Calmodulin/IQ domain complex | 分子名称: | CALCIUM ION, Calmodulin, MAGNESIUM ION, ... | 著者 | Fallon, J.L, Quiocho, F.A. | 登録日 | 2005-11-22 | 公開日 | 2005-12-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structure of Calmodulin Bound to the Hydrophobic IQ Domain of the Cardiac Ca(v)1.2 Calcium Channel. Structure, 13, 2005
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2H0H
| Crystal Structure of DsbG K113E mutant | 分子名称: | SULFATE ION, Thiol:disulfide interchange protein dsbG | 著者 | Hiniker, A, Heras, B, Martin, J.L, Stuckey, J, Bardwell, J.C.A. | 登録日 | 2006-05-15 | 公開日 | 2007-04-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Short-circuiting divergent evolution: laboratory evolution of one disulfide isomerase to resemble another To be Published
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2H0G
| Crystal Structure of DsbG T200M mutant | 分子名称: | SULFATE ION, Thiol:disulfide interchange protein dsbG | 著者 | Hiniker, A, Heras, B, Martin, J.L, Stuckey, J, Bardwell, J.C.A. | 登録日 | 2006-05-15 | 公開日 | 2007-04-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Short-circuiting divergent evolution: laboratory evolution of one disulfide isomerase to resemble another To be Published
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1UT6
| Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with N-9-(1',2',3',4'-Tetrahydroacridinyl)-1,8- diaminooctane at 2.4 angstroms resolution. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8-DIAMINOOCTANE | 著者 | Brumshtein, B, Wong, D.M, Greenblatt, H.M, Carlier, P.R, Pang, Y.-P, Silman, I, Sussman, J.L. | 登録日 | 2003-12-04 | 公開日 | 2005-04-21 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Complexes of Alkylene-Linked Tacrine Dimers with Torpedo Californica Acetylcholinesterase: Binding of Bis(5)-Tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge. J.Med.Chem., 49, 2006
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2H0I
| Crystal Structure of DsbG V216M mutant | 分子名称: | SULFATE ION, Thiol:disulfide interchange protein dsbG | 著者 | Hiniker, A, Heras, B, Martin, J.L, Stuckey, J, Bardwell, J.C.A. | 登録日 | 2006-05-15 | 公開日 | 2007-04-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Short-circuiting divergent evolution: laboratory evolution of one disulfide isomerase to resemble another To be Published
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2HH5
| Crystal Structure of Cathepsin S in complex with a Zinc mediated non-covalent arylaminoethyl amide | 分子名称: | CHLORIDE ION, Cathepsin S, N-[(1R)-1-[(BENZYLSULFONYL)METHYL]-2-{[(1S)-1-METHYL-2-{[4-(TRIFLUOROMETHOXY)PHENYL]AMINO}ETHYL]AMINO}-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE, ... | 著者 | Spraggon, G, Hornsby, M, Lesley, S.A, Tully, D.C, Harris, J.L, Karenewsky, D.S. | 登録日 | 2006-06-27 | 公開日 | 2006-08-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers. Bioorg.Med.Chem.Lett., 16, 2006
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1EVE
| THREE DIMENSIONAL STRUCTURE OF THE ANTI-ALZHEIMER DRUG, E2020 (ARICEPT), COMPLEXED WITH ITS TARGET ACETYLCHOLINESTERASE | 分子名称: | 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kryger, G, Silman, I, Sussman, J.L. | 登録日 | 1998-03-04 | 公開日 | 1999-01-20 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure Fold.Des., 7, 1999
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1FSS
| ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH FASCICULIN-II | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, FASCICULIN II, ... | 著者 | Harel, M, Kleywegt, G.J, Silman, I, Sussman, J.L. | 登録日 | 1995-10-25 | 公開日 | 1996-03-08 | 最終更新日 | 2021-06-02 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target. Structure, 3, 1995
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6TJP
| Crystal structure of T7 bacteriophage portal protein, 13mer, closed valve - P212121 | 分子名称: | Portal protein | 著者 | Fabrega-Ferrer, M, Cuervo, A, Fernandez, F.J, Machon, C, Perez-Luque, R, Pous, J, Vega, M.C, Carrascosa, J.L, Coll, M. | 登録日 | 2019-11-26 | 公開日 | 2020-12-16 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.74 Å) | 主引用文献 | Using a partial atomic model from medium-resolution cryo-EM to solve a large crystal structure. Acta Crystallogr D Struct Biol, 77, 2021
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1GCD
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