4DNC
 
 | | Crystal structure of human MOF in complex with MSL1 | | Descriptor: | Histone acetyltransferase KAT8, Male-specific lethal 1 homolog, ZINC ION | | Authors: | Huang, J, Lei, M. | | Deposit date: | 2012-02-08 | | Release date: | 2012-07-25 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex.
Cell Res., 22, 2012
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5GHE
 | | Crystal Structure of Bacillus thuringiensis Cry6Aa2 Protoxin | | Descriptor: | Pesticidal crystal protein Cry6Aa | | Authors: | Huang, J, Guan, Z, Zou, T, Sun, M, Yin, P. | | Deposit date: | 2016-06-19 | | Release date: | 2016-08-03 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | Crystal structure of Cry6Aa: A novel nematicidal ClyA-type alpha-pore-forming toxin from Bacillus thuringiensis
Biochem.Biophys.Res.Commun., 478, 2016
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5H73
 | | Crystal structure of human DHODH with 18F | | Descriptor: | ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | | Authors: | Huang, J, Wu, D. | | Deposit date: | 2016-11-16 | | Release date: | 2017-07-26 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Crystal structure of human DHODH with 18F at 1.58 Angstroms resolution
To Be Published
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5HIN
 | | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18L compound | | Descriptor: | ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | | Authors: | Huang, J, Wu, D, Lu, Q, Yao, X. | | Deposit date: | 2016-01-12 | | Release date: | 2016-07-20 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18L at 1.60 A resolution
To Be Published
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5HQE
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3LLY
 | | Crystal Structure Analysis of Maclura pomifera agglutinin | | Descriptor: | Agglutinin alpha chain, Agglutinin beta-2 chain | | Authors: | Huang, J, Xu, Z, Wang, D, Ogato, C, Hirama, T, Palczewski, K, Hazen, S.L, Lee, X, Young, N.M. | | Deposit date: | 2010-01-29 | | Release date: | 2010-09-22 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses.
Glycobiology, 20, 2010
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3LLZ
 | | Crystal Structure Analysis of Maclura pomifera agglutinin complex with Gal-beta-1,3-GalNAc | | Descriptor: | Agglutinin alpha chain, Agglutinin beta-2 chain, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose | | Authors: | Huang, J, Xu, Z, Wang, D, Ogato, C, Hirama, T, Palczewski, K, Hazen, S.L, Lee, X, Young, N.M. | | Deposit date: | 2010-01-29 | | Release date: | 2010-09-22 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses.
Glycobiology, 20, 2010
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5C11
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5CAE
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3LM1
 | | Crystal Structure Analysis of Maclura pomifera agglutinin complex with p-nitrophenyl-GalNAc | | Descriptor: | 4-nitrophenyl 2-acetamido-2-deoxy-beta-D-glucopyranoside, Agglutinin alpha chain, Agglutinin beta-2 chain | | Authors: | Huang, J, Xu, Z, Wang, D, Ogato, C, Hirama, T, Palczewski, K, Hazen, S.L, Lee, X, Young, N.M. | | Deposit date: | 2010-01-29 | | Release date: | 2010-09-22 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses.
Glycobiology, 20, 2010
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3U85
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3U86
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3U88
 | | Crystal structure of human menin in complex with MLL1 and LEDGF | | Descriptor: | (4beta,8alpha,9R)-6'-methoxy-10,11-dihydrocinchonan-9-ol, CHOLIC ACID, GLYOXYLIC ACID, ... | | Authors: | Huang, J, Wan, B, Lei, M. | | Deposit date: | 2011-10-16 | | Release date: | 2012-02-15 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature, 482, 2012
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3U84
 | | Crystal Structure of Human Menin | | Descriptor: | Menin | | Authors: | Huang, J, Wan, B, Lei, M. | | Deposit date: | 2011-10-15 | | Release date: | 2012-02-15 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature, 482, 2012
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2QBW
 | | The crystal structure of PDZ-Fibronectin fusion protein | | Descriptor: | PDZ-Fibronectin fusion protein, Polypeptide | | Authors: | Huang, J, Makabe, K, Koide, A, Koide, S. | | Deposit date: | 2007-06-18 | | Release date: | 2008-04-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Design of protein function leaps by directed domain interface evolution.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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7M0I
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7JMK
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7JKR
 | | GTP-specific succinyl-CoA synthetase complexed with Mg-GMPPNP, phosphohistidine loop pointing towards nucleotide binding site | | Descriptor: | GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Huang, J, Fraser, M.E. | | Deposit date: | 2020-07-28 | | Release date: | 2021-03-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | Second distinct conformation of the phosphohistidine loop in succinyl-CoA synthetase
Acta Crystallogr.,Sect.D, 77, 2021
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7JFP
 | | GTP-specific succinyl-CoA synthetase complexed with Mg-GDP, phosphohistidine loop pointing towards nucleotide binding site | | Descriptor: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Huang, J, Fraser, M.E. | | Deposit date: | 2020-07-17 | | Release date: | 2021-03-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Second distinct conformation of the phosphohistidine loop in succinyl-CoA synthetase
Acta Crystallogr.,Sect.D, 77, 2021
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7JJ0
 | | GTP-specific succinyl-CoA synthetase complexed with Mg-GMPPCP | | Descriptor: | MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, ... | | Authors: | Huang, J, Fraser, M.E. | | Deposit date: | 2020-07-24 | | Release date: | 2021-03-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Second distinct conformation of the phosphohistidine loop in succinyl-CoA synthetase
Acta Crystallogr.,Sect.D, 77, 2021
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9AYG
 | | Cryo-EM structure of apo state human Cav3.2 | | Descriptor: | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Fan, X, Huang, J, Yan, N. | | Deposit date: | 2024-03-07 | | Release date: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis for human Ca v 3.2 inhibition by selective antagonists.
Cell Res., 2024
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9AYH
 | | Cryo-EM structure of human Cav3.2 with TTA-A2 | | Descriptor: | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(4-cyclopropylphenyl)-N-{(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Fan, X, Huang, J, Yan, N. | | Deposit date: | 2024-03-07 | | Release date: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for human Ca v 3.2 inhibition by selective antagonists.
Cell Res., 2024
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9AYJ
 | | Cryo-EM structure of human Cav3.2 with TTA-P2 | | Descriptor: | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-dichloro-N-[(1-{[(4S)-2,2-dimethyloxan-4-yl]methyl}-4-fluoropiperidin-4-yl)methyl]benzamide, ... | | Authors: | Fan, X, Huang, J, Yan, N. | | Deposit date: | 2024-03-07 | | Release date: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis for human Ca v 3.2 inhibition by selective antagonists.
Cell Res., 2024
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9AYK
 | | Cryo-EM structure of human Cav3.2 with ML218 | | Descriptor: | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-dichloro-N-{[(1R,5S,6r)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl}benzamide, ... | | Authors: | Fan, X, Huang, J, Yan, N. | | Deposit date: | 2024-03-08 | | Release date: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis for human Ca v 3.2 inhibition by selective antagonists.
Cell Res., 2024
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9AYL
 | | Cryo-EM structure of human Cav3.2 with ACT-709478 | | Descriptor: | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Fan, X, Huang, J, Yan, N. | | Deposit date: | 2024-03-08 | | Release date: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural basis for human Ca v 3.2 inhibition by selective antagonists.
Cell Res., 2024
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