8JUL
 
 | | Cryo-EM structure of SIDT1 in complex with phosphatidic acid | | 分子名称: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, SID1 transmembrane family member 1, ZINC ION | | 著者 | Sun, C.R, Xu, D, Li, Q, Zhou, C.Z, Chen, Y. | | 登録日 | 2023-06-26 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Human SIDT1 mediates dsRNA uptake via its phospholipase activity.
Cell Res., 34, 2024
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8JUN
 | | Cryo-EM structure of SIDT1 E555Q mutant | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SID1 transmembrane family member 1, ZINC ION | | 著者 | Sun, C.R, Xu, D, Li, Q, Zhou, C.Z, Chen, Y. | | 登録日 | 2023-06-26 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (2.38 Å) | | 主引用文献 | Human SIDT1 mediates dsRNA uptake via its phospholipase activity.
Cell Res., 34, 2024
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8FHS
 | | Human L-type voltage-gated calcium channel Cav1.2 in the presence of amiodarone and sofosbuvir at 3.3 Angstrom resolution | | 分子名称: | (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Gao, S, Yao, X, Yan, N. | | 登録日 | 2022-12-15 | | 公開日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine.
Cell, 186, 2023
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8I5X
 | | Structure of human Nav1.7 in complex with Vinpocetine | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Wu, Q.R, Yan, N. | | 登録日 | 2023-01-26 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
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8I5G
 | | Structure of human Nav1.7 in complex with PF-05089771 | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Wu, Q.R, Yan, N. | | 登録日 | 2023-01-25 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
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8I5B
 | | Structure of human Nav1.7 in complex with bupivacaine | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wu, Q.R, Yan, N. | | 登録日 | 2023-01-24 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
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8I5Y
 | | Structure of human Nav1.7 in complex with vixotrigine | | 分子名称: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Wu, Q.R, Yan, N. | | 登録日 | 2023-01-26 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
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8J4F
 | | Structure of human Nav1.7 in complex with Hardwickii acid | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (4~{a}~{R},5~{S},6~{R},8~{a}~{R})-5-[2-(furan-3-yl)ethyl]-5,6,8~{a}-trimethyl-3,4,4~{a},6,7,8-hexahydronaphthalene-1-carboxylic acid, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Wu, Q.R, Yan, N. | | 登録日 | 2023-04-19 | | 公開日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
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6WZW
 | | Ash1L SET domain in complex with AS-85 | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Histone-lysine N-methyltransferase ASH1L, N-{[3-(3-carbamothioylphenyl)-1-{1-[(trifluoromethyl)sulfonyl]piperidin-4-yl}-1H-indol-6-yl]methyl}azetidine-3-carboxamide, ... | | 著者 | Li, H, Deng, J, Cierpicki, T, Grembecka, J. | | 登録日 | 2020-05-14 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.
Nat Commun, 12, 2021
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6X0P
 | | Ash1L SET domain Q2265A mutant in complex with AS-5 | | 分子名称: | 3-[6-(aminomethyl)-1-(2-hydroxyethyl)-1H-indol-3-yl]benzene-1-carbothioamide, Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ... | | 著者 | Rogawski, D.S, Li, H, Borkin, D, Cierpicki, T, Grembecka, J. | | 登録日 | 2020-05-17 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.
Nat Commun, 12, 2021
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7WFW
 | | Apo human Nav1.8 | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N, Pan, X.J, Huang, X.S, Huang, G.X. | | 登録日 | 2021-12-27 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-09-21 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7WEL
 | | Human Nav1.8 with A-803467, class II | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N, Pan, X.J, Huang, X.S, Huang, G.X. | | 登録日 | 2021-12-23 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-09-21 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7WE4
 | | Human Nav1.8 with A-803467, class I | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N, Pan, X.J, Huang, X.S, Huang, G.X. | | 登録日 | 2021-12-22 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-09-21 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7WFR
 | | Human Nav1.8 with A-803467, class III | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N, Pan, X.J, Huang, X.S, Huang, G.X. | | 登録日 | 2021-12-27 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-09-21 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8.
Proc.Natl.Acad.Sci.USA, 119, 2022
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6A72
 | | Copper transporter protein | | 分子名称: | ATP7B protein, CALCIUM ION, dioxo(di-mu-sulfide)dimolybdenum | | 著者 | Chen, W.B. | | 登録日 | 2018-07-01 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein.
Nat Commun, 10, 2019
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6A71
 | | Crystal Structure of Human ATP7B and TM Complex | | 分子名称: | ATP7B protein, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Chen, W.B. | | 登録日 | 2018-06-30 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein.
Nat Commun, 10, 2019
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2B3R
 | | Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2 | | 分子名称: | Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide, SULFATE ION | | 著者 | Liu, L, Song, X, He, D, Komma, C, Kita, A, Verbasius, J.V, Bellamy, H, Miki, K, Czech, M.P, Zhou, G.W. | | 登録日 | 2005-09-20 | | 公開日 | 2005-12-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha.
J.Biol.Chem., 281, 2006
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6KZP
 | | calcium channel-ligand | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Yan, N. | | 登録日 | 2019-09-25 | | 公開日 | 2019-12-18 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Cryo-EM structures of apo and antagonist-bound human Cav3.1.
Nature, 576, 2019
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6KZO
 | | membrane protein | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Yan, N. | | 登録日 | 2019-09-25 | | 公開日 | 2019-12-18 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of apo and antagonist-bound human Cav3.1.
Nature, 576, 2019
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8HBN
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8HFR
 | | NPC-trapped pre-60S particle | | 分子名称: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | 著者 | Li, Z.Q, Chen, S.J, Sui, S.F. | | 登録日 | 2022-11-12 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-06-28 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | Nuclear export of pre-60S particles through the nuclear pore complex.
Nature, 618, 2023
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5V89
 | | Structure of DCN4 PONY domain bound to CUL1 WHB | | 分子名称: | Cullin-1, DCN1-like protein 4 | | 著者 | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | | 登録日 | 2017-03-21 | | 公開日 | 2017-05-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Nat. Chem. Biol., 13, 2017
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5V83
 | | Structure of DCN1 bound to NAcM-HIT | | 分子名称: | Lysozyme,DCN1-like protein 1 chimera, N-(1-benzylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea | | 著者 | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | | 登録日 | 2017-03-21 | | 公開日 | 2017-05-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | | 主引用文献 | Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Nat. Chem. Biol., 13, 2017
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5V86
 | | Structure of DCN1 bound to NAcM-OPT | | 分子名称: | Lysozyme,DCN1-like protein 1, N-benzyl-N-(1-butylpiperidin-4-yl)-N'-(3,4-dichlorophenyl)urea | | 著者 | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | | 登録日 | 2017-03-21 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.374 Å) | | 主引用文献 | Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Nat. Chem. Biol., 13, 2017
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5V88
 | | Structure of DCN1 bound to NAcM-COV | | 分子名称: | Lysozyme,DCN1-like protein 1, N-{2-[({1-[(2R)-pentan-2-yl]piperidin-4-yl}{[3-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]phenyl}propanamide | | 著者 | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | | 登録日 | 2017-03-21 | | 公開日 | 2017-05-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | | 主引用文献 | Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Nat. Chem. Biol., 13, 2017
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