2DSR
| Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins | Descriptor: | Insulin-like growth factor IB, Insulin-like growth factor-binding protein 4 | Authors: | Sitar, T, Popowicz, G.M, Siwanowicz, I, Huber, R, Holak, T.A. | Deposit date: | 2006-07-05 | Release date: | 2006-08-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2GRC
| 1.5 A structure of bromodomain from human BRG1 protein, a central ATPase of SWI/SNF remodeling complex | Descriptor: | Probable global transcription activator SNF2L4 | Authors: | Singh, M, Popowicz, G.M, Krajewski, M, Holak, T.A. | Deposit date: | 2006-04-24 | Release date: | 2007-05-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex. Chembiochem, 8, 2007
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3JTZ
| Structure of the arm-type binding domain of HPI integrase | Descriptor: | Integrase, SODIUM ION | Authors: | Szwagierczak, A, Antonenka, U, Popowicz, G.M, Sitar, T, Holak, T.A, Rakin, A. | Deposit date: | 2009-09-14 | Release date: | 2009-10-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structures of the arm-type binding domains of HPI and HAI7 integrases J.Biol.Chem., 284, 2009
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3JU0
| Structure of the arm-type binding domain of HAI7 integrase | Descriptor: | Phage integrase | Authors: | Szwagierczak, A, Antonenka, U, Popowicz, G.M, Sitar, T, Holak, T.A, Rakin, A. | Deposit date: | 2009-09-14 | Release date: | 2009-10-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structures of the arm-type binding domains of HPI and HAI7 integrases J.Biol.Chem., 284, 2009
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3LBL
| Structure of human MDM2 protein in complex with Mi-63-analog | Descriptor: | (2'R,3R,4'R,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2 | Authors: | Popowicz, G.M, Czarna, A, Wolf, S, Holak, T.A. | Deposit date: | 2010-01-08 | Release date: | 2010-03-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery Cell Cycle, 9, 2010
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3LBK
| Structure of human MDM2 protein in complex with a small molecule inhibitor | Descriptor: | 6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indole-2-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | Authors: | Popowicz, G.M, Czarna, A, Wolf, S, Holak, T.A. | Deposit date: | 2010-01-08 | Release date: | 2010-03-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery Cell Cycle, 9, 2010
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3LBJ
| Structure of human MDMX protein in complex with a small molecule inhibitor | Descriptor: | N-[(3S)-1-({6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indol-2-yl}carbonyl)pyrrolidin-3-yl]-N,N',N'-trimethylpropane-1,3-diamine, Protein Mdm4, SULFATE ION | Authors: | Popowicz, G.M, Czarna, A, Wolf, S, Holak, T.A. | Deposit date: | 2010-01-08 | Release date: | 2010-03-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery Cell Cycle, 9, 2010
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3MN7
| Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-5C, CALCIUM ION, ... | Authors: | Ducka, A.M, Sitar, T, Popowicz, G.M, Huber, R, Holak, T.A. | Deposit date: | 2010-04-21 | Release date: | 2010-05-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proc.Natl.Acad.Sci.USA, 107, 2010
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3MN6
| Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-5C, CALCIUM ION, ... | Authors: | Ducka, A.M, Sitar, T, Popowicz, G.M, Huber, R, Holak, T.A. | Deposit date: | 2010-04-21 | Release date: | 2010-06-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proc.Natl.Acad.Sci.USA, 107, 2010
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3MN9
| Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-5C, CALCIUM ION, ... | Authors: | Ducka, A.M, Sitar, T, Popowicz, G.M, Huber, R, Holak, T.A. | Deposit date: | 2010-04-21 | Release date: | 2010-05-26 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proc.Natl.Acad.Sci.USA, 107, 2010
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3MMV
| Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-5C, CALCIUM ION, ... | Authors: | Ducka, A.M, Sitar, T, Popowicz, G.M, Huber, R, Holak, T.A. | Deposit date: | 2010-04-20 | Release date: | 2010-06-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proc.Natl.Acad.Sci.USA, 107, 2010
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3MN5
| Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Ducka, A.M, Sitar, T, Popowicz, G.M, Huber, R, Holak, T.A. | Deposit date: | 2010-04-21 | Release date: | 2010-06-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proc.Natl.Acad.Sci.USA, 107, 2010
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1ZFI
| Solution structure of the leech carboxypeptidase inhibitor | Descriptor: | Metallocarboxypeptidase inhibitor | Authors: | Arolas, J.L, D'Silva, L, Popowicz, G.M, Aviles, F.X, Holak, T.A, Ventura, S. | Deposit date: | 2005-04-20 | Release date: | 2005-09-13 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor STRUCTURE, 13, 2005
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1ZFL
| Solution structure of III-A, the major intermediate in the oxidative folding of leech carboxypeptidase inhibitor | Descriptor: | Metallocarboxypeptidase inhibitor | Authors: | Arolas, J.L, D'Silva, L, Popowicz, G.M, Aviles, F.X, Holak, T.A, Ventura, S. | Deposit date: | 2005-04-20 | Release date: | 2005-09-13 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor STRUCTURE, 13, 2005
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1H59
| Complex of IGFBP-5 with IGF-I | Descriptor: | INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5, INSULIN-LIKE GROWTH FACTOR IA | Authors: | Zeslawski, W, Beisel, H.G, Kamionka, M, Kalus, W, Engh, R.A, Huber, R, Holak, T.A. | Deposit date: | 2001-05-21 | Release date: | 2002-05-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Interaction of Insulin-Like Growth Factor-I with the N-Terminal Domain of Igfbp-5 Embo J., 20, 2001
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1HJ0
| Thymosin beta9 | Descriptor: | THYMOSIN BETA9 | Authors: | Stoll, R, Voelter, W, Holak, T.A. | Deposit date: | 2001-01-05 | Release date: | 2002-01-04 | Last modified: | 2024-04-24 | Method: | SOLUTION NMR | Cite: | Conformation of Thymosin Beta9 in Water/Fluoroalcohol Solution Determined by NMR Spectroscopy Biopolymers, 41, 1997
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1HJD
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1I16
| STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES | Descriptor: | INTERLEUKIN 16 | Authors: | Muehlhahn, P, Zweckstetter, M, Georgescu, J, Ciosto, C, Renner, C, Lanzendoerfer, M, Lang, K, Ambrosius, D, Baier, M, Kurth, R, Holak, T.A. | Deposit date: | 1998-05-20 | Release date: | 1999-05-25 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site. Nat.Struct.Biol., 5, 1998
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1A24
| SOLUTION NMR STRUCTURE OF REDUCED DSBA FROM ESCHERICHIA COLI, FAMILY OF 20 STRUCTURES | Descriptor: | DSBA | Authors: | Schirra, H.J, Renner, C, Czisch, M, Huber-Wunderlich, M, Holak, T.A, Glockshuber, R. | Deposit date: | 1998-01-15 | Release date: | 1998-09-16 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Structure of reduced DsbA from Escherichia coli in solution. Biochemistry, 37, 1998
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1AG4
| NMR STRUCTURE OF SPHERULIN 3A (S3A) FROM PHYSARUM POLYCEPHALUM, MINIMIZED AVERAGE STRUCTURE | Descriptor: | SPHERULIN 3A | Authors: | Rosinke, B, Renner, C, Mayr, E.-M, Jaenicke, R, Holak, T.A. | Deposit date: | 1997-04-01 | Release date: | 1998-04-08 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Ca2+-loaded spherulin 3a from Physarum polycephalum adopts the prototype gamma-crystallin fold in aqueous solution. J.Mol.Biol., 271, 1997
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1A23
| SOLUTION NMR STRUCTURE OF REDUCED DSBA FROM ESCHERICHIA COLI, MINIMIZED AVERAGE STRUCTURE | Descriptor: | DSBA | Authors: | Schirra, H.J, Renner, C, Czisch, M, Huber-Wunderlich, M, Holak, T.A, Glockshuber, R. | Deposit date: | 1998-01-15 | Release date: | 1998-09-16 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Structure of reduced DsbA from Escherichia coli in solution. Biochemistry, 37, 1998
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1BD8
| STRUCTURE OF CDK INHIBITOR P19INK4D | Descriptor: | P19INK4D CDK4/6 INHIBITOR | Authors: | Baumgartner, R, Fernandez-Catalan, C, Winoto, A, Huber, R, Engh, R, Holak, T.A. | Deposit date: | 1998-05-12 | Release date: | 1998-10-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a. Structure, 6, 1998
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1DNY
| SOLUTION STRUCTURE OF PCP, A PROTOTYPE FOR THE PEPTIDYL CARRIER DOMAINS OF MODULAR PEPTIDE SYNTHETASES | Descriptor: | NON-RIBOSOMAL PEPTIDE SYNTHETASE PEPTIDYL CARRIER PROTEIN | Authors: | Weber, T, Baumgartner, R, Renner, C, Marahiel, M.A, Holak, T.A. | Deposit date: | 1999-12-17 | Release date: | 2000-05-17 | Last modified: | 2022-12-21 | Method: | SOLUTION NMR | Cite: | Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases. Structure Fold.Des., 8, 2000
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1QLO
| Structure of the active domain of the herpes simplex virus protein ICP47 in water/sodium dodecyl sulfate solution determined by nuclear magnetic resonance spectroscopy | Descriptor: | HERPES SIMPLEX VIRUS PROTEIN ICP47 | Authors: | Pfaender, R, Neumann, L, Zweckstetter, M, Seger, C, Holak, T.A, Tampe, R. | Deposit date: | 1999-09-09 | Release date: | 1999-12-14 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Structure of the Active Domain of the Herpes Simplex Virus Protein Icp47 in Water/Sodium Dodecyl Sulfate Solution Determined by Nuclear Magnetic Resonance Spectroscopy. Biochemistry, 38, 1999
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1S0P
| Structure of the N-Terminal Domain of the Adenylyl Cyclase-Associated Protein (CAP) from Dictyostelium discoideum. | Descriptor: | Adenylyl cyclase-associated protein, MAGNESIUM ION | Authors: | Ksiazek, D, Brandstetter, H, Israel, L, Bourenkov, G.P, Katchalova, G, Janssen, K.P, Bartunik, H.D, Noegel, A.A, Schleicher, M, Holak, T.A. | Deposit date: | 2004-01-01 | Release date: | 2004-01-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | STRUCTURE OF THE N-TERMINAL DOMAIN OF THE ADENYLYL
CYCLASE-ASSOCIATED PROTEIN (CAP) FROM DICTYOSTELIUM DISCOIDEUM Structure, 11, 2003
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