3ES9
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![BU of 3es9 by Molmil](/molmil-images/mine/3es9) | NADPH-Cytochrome P450 Reductase in an Open Conformation | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Hamdane, D, Xia, C, Im, S.-C, Zhang, H, Kim, J.-J, Waskell, L. | Deposit date: | 2008-10-05 | Release date: | 2009-01-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450 J.Biol.Chem., 284, 2009
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4WFS
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![BU of 4wfs by Molmil](/molmil-images/mine/4wfs) | Crystal Structure of tRNA-dihydrouridine(20) synthase catalytic domain | Descriptor: | CHLORIDE ION, FLAVIN MONONUCLEOTIDE, SULFATE ION, ... | Authors: | Bou-Nader, C, Pecqueur, L, Kamah, A, Bregeon, D, Golinelli-Pimpaneau, B, Guimaraes, B.G, Fontecave, M, Hamdane, D. | Deposit date: | 2014-09-17 | Release date: | 2015-10-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | An extended dsRBD is required for post-transcriptional modification in human tRNAs. Nucleic Acids Res., 43, 2015
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4WFT
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![BU of 4wft by Molmil](/molmil-images/mine/4wft) | Crystal structure of tRNA-dihydrouridine(20) synthase dsRBD domain | Descriptor: | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like | Authors: | Bou-Nader, C, Pecqueur, L, Kamah, A, Bregeon, D, Golinelli-Pimpaneau, B, Guimaraes, B.G, Fontecave, M, Hamdane, D. | Deposit date: | 2014-09-17 | Release date: | 2015-10-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | An extended dsRBD is required for post-transcriptional modification in human tRNAs. Nucleic Acids Res., 43, 2015
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8B02
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![BU of 8b02 by Molmil](/molmil-images/mine/8b02) | Crystal structure of the dsRBD domain of tRNA-dihydrouridine(20) synthase from Amphimedon queenslandica | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, DRBM domain-containing protein, ... | Authors: | Pecqueur, L, Faivre, B, Hamdane, D. | Deposit date: | 2022-09-07 | Release date: | 2022-11-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.676 Å) | Cite: | Evolutionary Diversity of Dus2 Enzymes Reveals Novel Structural and Functional Features among Members of the RNA Dihydrouridine Synthases Family. Biomolecules, 12, 2022
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7NDZ
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![BU of 7ndz by Molmil](/molmil-images/mine/7ndz) | ThyX reconstituted with N5-carbinolamine flavin | Descriptor: | DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent thymidylate synthase, ... | Authors: | Bou-Nader, C, Pecqueur, L, Hamdane, D. | Deposit date: | 2021-02-02 | Release date: | 2021-07-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | An enzymatic activation of formaldehyde for nucleotide methylation. Nat Commun, 12, 2021
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7NDW
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![BU of 7ndw by Molmil](/molmil-images/mine/7ndw) | ThyX-FADH2 soaked with 20 mM Formaldehyde | Descriptor: | DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent thymidylate synthase, ... | Authors: | Bou-Nader, C, Pecqueur, L, Hamdane, D. | Deposit date: | 2021-02-02 | Release date: | 2021-07-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | An enzymatic activation of formaldehyde for nucleotide methylation. Nat Commun, 12, 2021
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6EZB
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![BU of 6ezb by Molmil](/molmil-images/mine/6ezb) | Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain Q305K mutant | Descriptor: | FLAVIN MONONUCLEOTIDE, GLYCEROL, SULFATE ION, ... | Authors: | Bou-Nader, C, Bregeon, D, Pecqueur, L, Fontecave, M, Hamdane, D. | Deposit date: | 2017-11-14 | Release date: | 2018-09-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases. Biochemistry, 57, 2018
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6EZC
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![BU of 6ezc by Molmil](/molmil-images/mine/6ezc) | Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain E294K Q305K double mutant | Descriptor: | CHLORIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Bou-Nader, C, Bregeon, D, Vincent, G, Fontecave, M, Hamdane, D. | Deposit date: | 2017-11-14 | Release date: | 2018-09-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases. Biochemistry, 57, 2018
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6EZA
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![BU of 6eza by Molmil](/molmil-images/mine/6eza) | Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain E294K mutant | Descriptor: | CHLORIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Bou-Nader, C, Bregeon, D, Pecqueur, L, Vincent, G, Fontecave, M, Hamdane, D. | Deposit date: | 2017-11-14 | Release date: | 2018-09-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases. Biochemistry, 57, 2018
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6EI9
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![BU of 6ei9 by Molmil](/molmil-images/mine/6ei9) | Crystal structure of E. coli tRNA-dihydrouridine synthase B (DusB) | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Bou-Nader, C, Hamdane, D. | Deposit date: | 2017-09-18 | Release date: | 2018-01-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Unveiling structural and functional divergences of bacterial tRNA dihydrouridine synthases: perspectives on the evolution scenario. Nucleic Acids Res., 46, 2018
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3OJX
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![BU of 3ojx by Molmil](/molmil-images/mine/3ojx) | Disulfide crosslinked cytochrome P450 reductase inactive | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Xia, C, Hamdane, D, Shen, A, Choi, V, Kasper, C, Zhang, H, Im, S.-C, Waskell, L, Kim, J.-J.P. | Deposit date: | 2010-08-23 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding. J.Biol.Chem., 286, 2011
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5OC5
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![BU of 5oc5 by Molmil](/molmil-images/mine/5oc5) | |
5OC4
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![BU of 5oc4 by Molmil](/molmil-images/mine/5oc4) | Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD R361A-R362A mutant | Descriptor: | CACODYLATE ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Bou-nader, C, Pecqueur, L, Hamdane, D. | Deposit date: | 2017-06-29 | Release date: | 2018-12-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2. Nucleic Acids Res., 47, 2019
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3OJW
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![BU of 3ojw by Molmil](/molmil-images/mine/3ojw) | Disulfide crosslinked cytochrome P450 reductase inactive | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH-cytochrome P450 reductase | Authors: | Xia, C, Hamdane, D, Shen, A, Choi, V, Kasper, C, Zhang, H, Im, S.-C, Waskell, L, Kim, J.-J.P. | Deposit date: | 2010-08-23 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding. J.Biol.Chem., 286, 2011
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5OC6
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6EI8
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![BU of 6ei8 by Molmil](/molmil-images/mine/6ei8) | |
4MPM
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![BU of 4mpm by Molmil](/molmil-images/mine/4mpm) | Wild-type human neuroglobin | Descriptor: | Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Guimaraes, B.G, Golinelli-Pimpaneau, B. | Deposit date: | 2013-09-13 | Release date: | 2014-01-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | The crystal structure of wild-type human brain neuroglobin reveals flexibility of the disulfide bond that regulates oxygen affinity. Acta Crystallogr.,Sect.D, 70, 2014
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5EYL
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![BU of 5eyl by Molmil](/molmil-images/mine/5eyl) | TUBULIN-BINDING DARPIN | Descriptor: | DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN), GLYCEROL, PHOSPHATE ION | Authors: | Ahmad, S, Kossow, M, Gigant, B. | Deposit date: | 2015-11-25 | Release date: | 2016-07-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin. Sci Rep, 6, 2016
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5EYP
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![BU of 5eyp by Molmil](/molmil-images/mine/5eyp) | TUBULIN-DARPIN COMPLEX | Descriptor: | DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN), GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Ahmad, S, Knossow, M, Gigant, B. | Deposit date: | 2015-11-25 | Release date: | 2016-07-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin. Sci Rep, 6, 2016
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6ZMC
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![BU of 6zmc by Molmil](/molmil-images/mine/6zmc) | Structure of the tRNA-Monooxygenase enzyme MiaE frozen under 2000 bar using the high pressure freezing method | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ARGON, CALCIUM ION, ... | Authors: | Carpentier, P, Atta, M. | Deposit date: | 2020-07-02 | Release date: | 2020-09-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural, biochemical and functional analyses of tRNA-monooxygenase enzyme MiaE from Pseudomonas putida provide insights into tRNA/MiaE interaction. Nucleic Acids Res., 48, 2020
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6ZMB
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![BU of 6zmb by Molmil](/molmil-images/mine/6zmb) | Structure of the native tRNA-Monooxygenase enzyme MiaE | Descriptor: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | Authors: | Carpentier, P, Atta, M. | Deposit date: | 2020-07-02 | Release date: | 2020-09-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural, biochemical and functional analyses of tRNA-monooxygenase enzyme MiaE from Pseudomonas putida provide insights into tRNA/MiaE interaction. Nucleic Acids Res., 48, 2020
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6ZMA
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![BU of 6zma by Molmil](/molmil-images/mine/6zma) | Structure of the tRNA-Monooxygenase enzyme MiaE frozen under 140 bar of krypton using the soak and freeze methodology | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | Authors: | Carpentier, P, Atta, M. | Deposit date: | 2020-07-02 | Release date: | 2020-09-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural, biochemical and functional analyses of tRNA-monooxygenase enzyme MiaE from Pseudomonas putida provide insights into tRNA/MiaE interaction. Nucleic Acids Res., 48, 2020
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4H2D
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![BU of 4h2d by Molmil](/molmil-images/mine/4h2d) | Crystal structure of NDOR1 | Descriptor: | FLAVIN MONONUCLEOTIDE, NADPH-dependent diflavin oxidoreductase 1 | Authors: | Banci, L, Bertini, I, Calderone, V, Ciofi-Baffoni, S, Mikolajczyk, M, Jaiswal, D, Winkelmann, J. | Deposit date: | 2012-09-12 | Release date: | 2013-04-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis. Proc.Natl.Acad.Sci.USA, 110, 2013
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