7D37
 
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8I1G
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8I18
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8I19
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8I1H
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8I1E
 | | Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dATP at pH 8.0 | | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | | 著者 | Nakamura, T, Yamagata, Y. | | 登録日 | 2023-01-13 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-07-26 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
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8I1A
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8I1J
 | | Crystal structure of human MTH1(G2K/D120N mutant) in complex with 2-oxo-dATP at pH 9.7 | | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | | 著者 | Nakamura, T, Yamagata, Y. | | 登録日 | 2023-01-13 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-07-26 | | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | | 主引用文献 | Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
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8I1I
 | | Crystal structure of human MTH1(G2K/D120N mutant) in complex with 2-oxo-dATP at pH 7.7 | | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | | 著者 | Nakamura, T, Yamagata, Y. | | 登録日 | 2023-01-13 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-07-26 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
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8I1D
 | | Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dATP at pH 7.7 | | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | | 著者 | Nakamura, T, Yamagata, Y. | | 登録日 | 2023-01-13 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-07-26 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
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8I1C
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8I1F
 | | Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dATP at pH 8.6 | | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | | 著者 | Nakamura, T, Yamagata, Y. | | 登録日 | 2023-01-13 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-07-26 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
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8HSJ
 | | Thermus thermophilus transcription termination factor Rho bound with ADP-BeF3 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | 著者 | Murayama, Y, Ehara, H, Sekine, S. | | 登録日 | 2022-12-19 | | 公開日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
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8HSG
 | | Thermus thermophilus RNA polymerase elongation complex | | 分子名称: | DNA (27-MER), DNA (37-MER), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Murayama, Y, Ehara, H, Sekine, S. | | 登録日 | 2022-12-19 | | 公開日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
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8HSH
 | | Thermus thermophilus RNA polymerase coreenzyme | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Murayama, Y, Ehara, H, Sekine, S. | | 登録日 | 2022-12-19 | | 公開日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
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8HSL
 | | Thermus thermophilus RNA polymerase bound with an inverted Rho hexamer | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Murayama, Y, Ehara, H, Sekine, S. | | 登録日 | 2022-12-19 | | 公開日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
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8HSR
 | | Thermus thermophilus Rho-engaged RNAP elongation complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (31-MER), ... | | 著者 | Murayama, Y, Ehara, H, Sekine, S. | | 登録日 | 2022-12-20 | | 公開日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
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8I8T
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8I8S
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6IYQ
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5X9O
 | | Crystal structure of the BCL6 BTB domain in complex with Compound 1a | | 分子名称: | 1,2-ETHANEDIOL, 5-[(2-chloranyl-4-nitro-phenyl)amino]-1,3-dihydrobenzimidazol-2-one, B-cell lymphoma 6 protein, ... | | 著者 | Sogabe, S, Ida, K, Lane, W, Snell, G. | | 登録日 | 2017-03-08 | | 公開日 | 2017-08-16 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design
Bioorg. Med. Chem., 25, 2017
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5X9P
 | | Crystal structure of the BCL6 BTB domain in complex with Compound 5 | | 分子名称: | 3-[[4-chloranyl-2-nitro-5-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)amino]phenyl]amino]propanoic acid, B-cell lymphoma 6 protein | | 著者 | Sogabe, S, Ida, K, Lane, W, Snell, G. | | 登録日 | 2017-03-08 | | 公開日 | 2017-08-16 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design
Bioorg. Med. Chem., 25, 2017
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6ANL
 | | Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors | | 分子名称: | Mitogen-activated protein kinase 14, TAK-715 | | 著者 | Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C. | | 登録日 | 2017-08-14 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors.
Bioorg. Med. Chem., 26, 2018
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5ZFI
 | | Mouse kallikrein 7 in complex with 6-benzyl-1,4-diazepan-7-one derivative | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[(3Z,6R)-6-[(2,6-dichlorophenyl)methyl]-3-(dimethylhydrazinylidene)-7-oxo-1,4-diazepan-1-yl]-N-[3-(1-methyl-1H-pyrazol-4-yl)phenyl]acetamide, Kallikrein-7 | | 著者 | Sugawara, H. | | 登録日 | 2018-03-06 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones.
Bioorg. Med. Chem., 26, 2018
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5ZFH
 | | Mouse Kallikrein 7 | | 分子名称: | Kallikrein-7 | | 著者 | Sugawara, H. | | 登録日 | 2018-03-06 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones.
Bioorg. Med. Chem., 26, 2018
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