8I1G

Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dATP at pH 9.1

Summary for 8I1G

Entry DOI	10.2210/pdb8i1g/pdb
Descriptor	7,8-dihydro-8-oxoguanine triphosphatase, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate, SODIUM ION, ... (5 entities in total)
Functional Keywords	nudix hydrolase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	36893.50
Authors	Nakamura, T.,Yamagata, Y. (deposition date: 2023-01-13, release date: 2023-03-22, Last modification date: 2023-07-26)
Primary citation	Nakamura, T.,Koga-Ogawa, Y.,Fujimiya, K.,Chirifu, M.,Goto, M.,Ikemizu, S.,Nakabeppu, Y.,Yamagata, Y. Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition. Febs Lett., 597:1770-1778, 2023 Cited by PubMed: 36914375 DOI: 10.1002/1873-3468.14611 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.18 Å)

Structure validation