8I8T

Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dAMP and Mn2+

Summary for 8I8T

Entry DOI	10.2210/pdb8i8t/pdb
Descriptor	7,8-dihydro-8-oxoguanine triphosphatase, 2'-DEOXYISOGUANINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, ... (4 entities in total)
Functional Keywords	nudix hydrolase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	37001.37
Authors	Nakamura, T.,Yamagata, Y. (deposition date: 2023-02-05, release date: 2023-03-22, Last modification date: 2023-07-26)
Primary citation	Nakamura, T.,Koga-Ogawa, Y.,Fujimiya, K.,Chirifu, M.,Goto, M.,Ikemizu, S.,Nakabeppu, Y.,Yamagata, Y. Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition. Febs Lett., 597:1770-1778, 2023 Cited by PubMed: 36914375 DOI: 10.1002/1873-3468.14611 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.22 Å)

Structure validation