8E6N
 
 | | X-ray structure of the Deinococcus radiodurans Nramp/MntH divalent transition metal transporter G223W mutant in an outward-open, manganese-bound state | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, DI(HYDROXYETHYL)ETHER, Divalent metal cation transporter MntH, ... | | Authors: | Bozzi, A.T, Ray, S, Zimanyi, C.M, Nicoludis, J.M, Gaudet, R. | | Deposit date: | 2022-08-22 | | Release date: | 2023-05-03 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | High-resolution structures with bound Mn 2+ and Cd 2+ map the metal import pathway in an Nramp transporter.
Elife, 12, 2023
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8E6H
 | | X-ray structure of the Deinococcus radiodurans Nramp/MntH divalent transition metal transporter A47W mutant in an occluded, manganese-bound state | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Ray, S, Gaudet, R. | | Deposit date: | 2022-08-22 | | Release date: | 2023-05-03 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | High-resolution structures with bound Mn 2+ and Cd 2+ map the metal import pathway in an Nramp transporter.
Elife, 12, 2023
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8E6M
 | | X-ray structure of the Deinococcus radiodurans Nramp/MntH divalent transition metal transporter WT in an inward-open, cadmium-bound state | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CADMIUM ION, CHLORIDE ION, ... | | Authors: | Ray, S, Gaudet, R. | | Deposit date: | 2022-08-22 | | Release date: | 2023-05-03 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | High-resolution structures with bound Mn 2+ and Cd 2+ map the metal import pathway in an Nramp transporter.
Elife, 12, 2023
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8E6L
 | | X-ray structure of the Deinococcus radiodurans Nramp/MntH divalent transition metal transporter D296A mutant in an inward-open, manganese-bound state | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, Divalent metal cation transporter MntH, ... | | Authors: | Ray, S, Gaudet, R. | | Deposit date: | 2022-08-22 | | Release date: | 2023-05-03 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.12 Å) | | Cite: | High-resolution structures with bound Mn 2+ and Cd 2+ map the metal import pathway in an Nramp transporter.
Elife, 12, 2023
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1IM3
 | | Crystal Structure of the human cytomegalovirus protein US2 bound to the MHC class I molecule HLA-A2/tax | | Descriptor: | HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, Human T-cell lymphotropic virus type 1 Tax peptide, ... | | Authors: | Gewurz, B.E, Gaudet, R, Tortorella, D, Wang, E.W, Ploegh, H.L, Wiley, D.C. | | Deposit date: | 2001-05-09 | | Release date: | 2001-06-06 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2.
Proc.Natl.Acad.Sci.USA, 98, 2001
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6MEQ
 | | PcdhgB3 EC1-4 in 50 mM HEPES | | Descriptor: | CALCIUM ION, Protocadherin gamma-B3 | | Authors: | Nicoludis, J.M, Gaudet, R. | | Deposit date: | 2018-09-06 | | Release date: | 2019-09-04 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6MER
 | | PcdhgB3 EC1-4 in 50 mM HEPES | | Descriptor: | CALCIUM ION, Protocadherin gamma-B3 | | Authors: | Nicoludis, J.M, Gaudet, R. | | Deposit date: | 2018-09-06 | | Release date: | 2019-09-04 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis.
Proc.Natl.Acad.Sci.USA, 116, 2019
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5K8R
 | | Structure of human clustered protocadherin gamma B3 EC1-4 | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Nicoludis, J.M, Vogt, B.E, Gaudet, R. | | Deposit date: | 2016-05-30 | | Release date: | 2016-08-24 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4.
Elife, 5, 2016
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5KTE
 | | Crystal structure of Deinococcus radiodurans MntH, an Nramp-family transition metal transporter | | Descriptor: | Divalent metal cation transporter MntH, Fab Heavy Chain, Fab Light Chain, ... | | Authors: | Bane, L.B, Gaudet, R, Weihofen, W.A, Singharoy, A. | | Deposit date: | 2016-07-11 | | Release date: | 2016-11-23 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.941 Å) | | Cite: | Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter.
Structure, 24, 2016
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5T4N
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5T4M
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4WAI
 | | Structural characterization of the late competence protein ComFB from Bacillus subtilis. | | Descriptor: | ComF operon protein 2, ZINC ION | | Authors: | Sysoeva, T.A, Bane, L.B, Xiao, D, Gaudet, R, Burton, B.M. | | Deposit date: | 2014-08-29 | | Release date: | 2014-12-10 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.427 Å) | | Cite: | Structural characterization of the late competence protein ComFB from Bacillus subtilis.
Biosci.Rep., 35, 2015
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6D91
 | | Crystal structure of the Deinococcus radiodurans Nramp/MntH divalent transition metal transporter in the outward-open, apo conformation | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Divalent metal cation transporter MntH | | Authors: | Bozzi, A.T, Zimanyi, C.M, Nicoludis, J.M, Gaudet, R. | | Deposit date: | 2018-04-27 | | Release date: | 2019-02-13 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.356 Å) | | Cite: | Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter.
Elife, 8, 2019
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2WDT
 | | Crystal structure of Plasmodium falciparum UCHL3 in complex with the suicide inhibitor UbVME | | Descriptor: | CHLORIDE ION, UBIQUITIN, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE L3 | | Authors: | Weihofen, W.A, Artavanis-Tsakonas, K, Gaudet, R, Ploegh, H.L. | | Deposit date: | 2009-03-26 | | Release date: | 2009-12-29 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Characterization and Structural Studies of the Plasmodium Falciparum Ubiquitin and Nedd8 Hydrolase Uchl3.
J.Biol.Chem., 285, 2010
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2WD0
 | | CRYSTAL STRUCTURE OF NONSYNDROMIC DEAFNESS (DFNB12) ASSOCIATED MUTANT D124G OF MOUSE CADHERIN-23 EC1-2 | | Descriptor: | CADHERIN-23, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2009-03-18 | | Release date: | 2010-04-21 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | Structural Determinants of Cadherin-23 Function in Hearing and Deafness.
Neuron, 66, 2010
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2WE6
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2WCP
 | | CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 | | Descriptor: | CADHERIN-23, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2009-03-13 | | Release date: | 2010-04-21 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Structural Determinants of Cadherin-23 Function in Hearing and Deafness.
Neuron, 66, 2010
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2WBX
 | | Crystal structure of mouse cadherin-23 EC1 | | Descriptor: | CADHERIN-23, CALCIUM ION | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2009-03-05 | | Release date: | 2010-04-21 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural Determinants of Cadherin-23 Function in Hearing and Deafness.
Neuron, 66, 2010
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2WHV
 | | CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 (ALL CATION BINDING SITES OCCUPIED BY CALCIUM) | | Descriptor: | CADHERIN-23, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2009-05-07 | | Release date: | 2010-04-21 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Structural Determinants of Cadherin-23 Function in Hearing and Deafness.
Neuron, 66, 2010
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4AQE
 | | CRYSTAL STRUCTURE OF DEAFNESS ASSOCIATED MUTANT MOUSE CADHERIN-23 EC1- 2S70P AND PROTOCADHERIN-15 EC1-2 FORM I | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CADHERIN-23, CALCIUM ION, ... | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2012-04-16 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Structure of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction
Nature, 492, 2012
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4AQA
 | | CRYSTAL STRUCTURE OF DEAFNESS ASSOCIATED MUTANT MOUSE CADHERIN-23 EC1- 2D124G AND PROTOCADHERIN-15 EC1-2 FORM I | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CADHERIN-23, CALCIUM ION, ... | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2012-04-15 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Structure of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction
Nature, 492, 2012
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4AQ8
 | | CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM II | | Descriptor: | CADHERIN-23, CALCIUM ION, PROTOCADHERIN-15 | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2012-04-13 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.63 Å) | | Cite: | Structure of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction
Nature, 492, 2012
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4APX
 | | CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM I | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CADHERIN-23, CALCIUM ION, ... | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2012-04-07 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction
Nature, 492, 2012
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4AXW
 | | CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2, FORM I 2.2A. | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CADHERIN-23, CALCIUM ION, ... | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2012-06-14 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | Structure of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction
Nature, 492, 2012
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4DX1
 | | Crystal structure of the human TRPV4 ankyrin repeat domain | | Descriptor: | GLYCEROL, PHOSPHATE ION, Transient receptor potential cation channel subfamily V member 4 | | Authors: | Inada, H, Gaudet, R. | | Deposit date: | 2012-02-27 | | Release date: | 2012-07-18 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel.
Biochemistry, 51, 2012
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