4JWY
 
 | | GluN2D ligand-binding core in complex with propyl-NHP5G | | 分子名称: | (2R)-amino(1-hydroxy-4-propyl-1H-pyrazol-5-yl)ethanoic acid, Glutamate receptor ionotropic, NMDA 2D | | 著者 | Hansen, K.B, Tajima, N, Risgaard, R, Perszyk, R.E, Jorgensen, L, Vance, K.M, Ogden, K.K, Clausen, R.P, Furukawa, H, Traynelis, S.F. | | 登録日 | 2013-03-27 | | 公開日 | 2013-05-29 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-d-aspartate receptors.
Mol.Pharmacol., 84, 2013
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8GMR
 | | Cryo-EM structure of octameric human CALHM1 | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calcium homeostasis modulator protein 1 | | 著者 | Syrjanen, J.L, Furukawa, H. | | 登録日 | 2023-03-27 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | | 主引用文献 | Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red.
Nat Commun, 14, 2023
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8GMQ
 | | Chicken CALHM1 purified from mammalian cells | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calcium homeostasis modulator 1 | | 著者 | Syrjanen, J.L, Furukawa, H. | | 登録日 | 2023-03-27 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red.
Nat Commun, 14, 2023
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8GMP
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7TEQ
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7TE9
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7TES
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7TE4
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7TET
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7TE6
 | | Crystal structure of GluN1b-2B ATD complexed to Fab5 anti-GluN2B antibody | | 分子名称: | Fab5 heavy chain, Fab5 light chain, Glutamate receptor ionotropic, ... | | 著者 | Regan, M, Tajima, N, Furukawa, H. | | 登録日 | 2022-01-04 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (4.55 Å) | | 主引用文献 | Development and characterization of functional antibodies targeting NMDA receptors.
Nat Commun, 13, 2022
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7TEE
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7TEB
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7TER
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5U8C
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5TQ0
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in the presence of EDTA | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ... | | 著者 | Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H. | | 登録日 | 2016-10-21 | | 公開日 | 2016-12-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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5TPZ
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in apo closed state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 2B, ... | | 著者 | Romero-Hernandez, A, Simorwski, N, Karakas, E, Furukawa, H. | | 登録日 | 2016-10-21 | | 公開日 | 2016-12-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.095 Å) | | 主引用文献 | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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5TQ2
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in complex with zinc at GluN1 and GluN2A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ... | | 著者 | Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H. | | 登録日 | 2016-10-21 | | 公開日 | 2016-12-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.289 Å) | | 主引用文献 | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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5TPW
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in complex with zinc at the GluN2A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ... | | 著者 | Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H. | | 登録日 | 2016-10-21 | | 公開日 | 2016-12-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.909 Å) | | 主引用文献 | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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3JPY
 | | Crystal structure of the zinc-bound amino terminal domain of the NMDA receptor subunit NR2B | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glutamate [NMDA] receptor subunit epsilon-2, ... | | 著者 | Karakas, E, Simorowski, N, Furukawa, H. | | 登録日 | 2009-09-04 | | 公開日 | 2009-12-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.209 Å) | | 主引用文献 | Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit.
Embo J., 28, 2009
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3JPW
 | | Crystal structure of amino terminal domain of the NMDA receptor subunit NR2B | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glutamate [NMDA] receptor subunit epsilon-2, ... | | 著者 | Karakas, E, Simorowski, N, Furukawa, H. | | 登録日 | 2009-09-04 | | 公開日 | 2009-12-08 | | 最終更新日 | 2021-10-13 | | 実験手法 | X-RAY DIFFRACTION (2.803 Å) | | 主引用文献 | Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit.
Embo J., 28, 2009
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3OEM
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6WHS
 | | GluN1b-GluN2B NMDA receptor in non-active 1 conformation at 3.95 angstrom resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Chou, T, Tajima, N, Furukawa, H. | | 登録日 | 2020-04-08 | | 公開日 | 2020-08-05 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural Basis of Functional Transitions in Mammalian NMDA Receptors.
Cell, 182, 2020
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6WHV
 | | GluN1b-GluN2B NMDA receptor in complex with SDZ 220-040 and L689,560, class 2 | | 分子名称: | (2R,4S)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid, (2S)-2-amino-3-[2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)biphenyl-3-yl]propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Chou, T, Tajima, N, Furukawa, H. | | 登録日 | 2020-04-08 | | 公開日 | 2020-08-05 | | 実験手法 | ELECTRON MICROSCOPY (4.05 Å) | | 主引用文献 | Structural Basis of Functional Transitions in Mammalian NMDA Receptors.
Cell, 182, 2020
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6WI1
 | | GluN1b-GluN2B NMDA receptor in active conformation stabilized by inter-GluN1b-GluN2B subunit cross-linking | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ionotropic glutamate receptor , ... | | 著者 | Chou, T, Tajima, N, Furukawa, H. | | 登録日 | 2020-04-08 | | 公開日 | 2020-07-15 | | 最終更新日 | 2020-08-05 | | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | | 主引用文献 | Structural Basis of Functional Transitions in Mammalian NMDA Receptors.
Cell, 182, 2020
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6WHR
 | | GluN1b-GluN2B NMDA receptor in non-active 2 conformation at 4 angstrom resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Chou, T, Tajima, N, Furukawa, H. | | 登録日 | 2020-04-08 | | 公開日 | 2020-08-05 | | 実験手法 | ELECTRON MICROSCOPY (3.99 Å) | | 主引用文献 | Structural Basis of Functional Transitions in Mammalian NMDA Receptors.
Cell, 182, 2020
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