6BX6
 
 | | AMP-Activated protein kinase (AMPK) inhibition by SBI-0206965: alpha 2 kinase domain bound to SBI-0206965 | | Descriptor: | 2-({5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}oxy)-N-methylbenzene-1-carboximidic acid, 5'-AMP-activated protein kinase catalytic subunit alpha-2 | | Authors: | Dite, T.A, Langendorf, C.G, Scott, J.W, Oakhill, J.S. | | Deposit date: | 2017-12-17 | | Release date: | 2018-05-09 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965.
J. Biol. Chem., 293, 2018
|
|
6B2E
 | | Structure of full length human AMPK (a2b2g1) in complex with a small molecule activator SC4. | | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... | | Authors: | Ngoei, K.R.W, Langendorf, C.G, Ling, N.X.Y, Hoque, A, Johnson, S, Camerino, M.C, Walker, S.R, Bozikis, Y.E, Dite, T.A, Ovens, A.J, Smiles, W.J, Jacobs, R, Huang, H, Parker, M.W, Scott, J.W, Rider, M.H, Kemp, B.E, Foitzik, R.C, Baell, J.B, Oakhill, J.S. | | Deposit date: | 2017-09-19 | | Release date: | 2018-04-25 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4.
Cell Chem Biol, 25, 2018
|
|
6B1U
 | | Structure of full-length human AMPK (a2b1g1) in complex with a small molecule activator SC4 | | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... | | Authors: | Ngoei, K.R.W, Langendorf, C.G, Ling, N.X.Y, Hoque, A, Johnson, S, Camerino, M.C, Walker, S.R, Bozikis, Y.E, Dite, T.A, Ovens, A.J, Smiles, W.J, Jacobs, R, Huang, H, Parker, M.W, Scott, J.W, Rider, M.H, Kemp, B.E, Foitzik, R.C, Baell, J.B, Oakhill, J.S. | | Deposit date: | 2017-09-19 | | Release date: | 2018-04-25 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.77 Å) | | Cite: | Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4.
Cell Chem Biol, 25, 2018
|
|
8U18
 | | Cryo-EM structure of murine Thrombopoietin receptor ectodomain in complex with Tpo | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombopoietin, Thrombopoietin receptor,GCN4 isoform 1, ... | | Authors: | Sarson-Lawrence, K.S, Hardy, J.M, Leis, A, Babon, J.J, Kershaw, N.J. | | Deposit date: | 2023-08-30 | | Release date: | 2024-02-07 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin.
Nat Commun, 15, 2024
|
|
8DGN
 | |
8DGM
 | | 14-3-3 epsilon bound to phosphorylated PEAK1 (pT1165) peptide | | Descriptor: | 1,2-ETHANEDIOL, 14-3-3 protein epsilon, Inactive tyrosine-protein kinase PEAK1 | | Authors: | Roy, M.J, Hardy, J.M, Lucet, I.S. | | Deposit date: | 2022-06-24 | | Release date: | 2023-06-07 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling.
Nat Commun, 14, 2023
|
|
8DGO
 | |
8DGP
 | | 14-3-3 epsilon bound to phosphorylated PEAK3 (pS69) peptide | | Descriptor: | 1,2-ETHANEDIOL, 14-3-3 protein epsilon, Phosphorylated PEAK3 (pS69) peptide, ... | | Authors: | Roy, M.J, Hardy, J.M, Lucet, I.S. | | Deposit date: | 2022-06-24 | | Release date: | 2023-06-07 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling.
Nat Commun, 14, 2023
|
|
9CDG
 | | MORC2 ATPase dead mutant - S87A | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATPase MORC2, MAGNESIUM ION, ... | | Authors: | Tan, W, Shakeel, S. | | Deposit date: | 2024-06-24 | | Release date: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (2.43 Å) | | Cite: | MORC2 is a phosphorylation-dependent DNA compaction machine.
Nat Commun, 16, 2025
|
|
9CDH
 | | MORC2 PD mutant with DNA | | Descriptor: | ATPase MORC2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Tan, W, Shakeel, S. | | Deposit date: | 2024-06-25 | | Release date: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (1.95 Å) | | Cite: | MORC2 is a phosphorylation-dependent DNA compaction machine.
Nat Commun, 16, 2025
|
|
9CDJ
 | | MORC2 ATPase with DNA | | Descriptor: | ATPase MORC2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Tan, W, Shakeel, S. | | Deposit date: | 2024-06-25 | | Release date: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (2.49 Å) | | Cite: | MORC2 is a phosphorylation-dependent DNA compaction machine.
Nat Commun, 16, 2025
|
|
9CDF
 | | Structure of MORC2 PD mutant binding to AMP-PNP | | Descriptor: | ATPase MORC2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Tan, W, Shakeel, S. | | Deposit date: | 2024-06-24 | | Release date: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (2.39 Å) | | Cite: | MORC2 is a phosphorylation-dependent DNA compaction machine.
Nat Commun, 16, 2025
|
|
9CDI
 | | MORC2 ATPase structure | | Descriptor: | ATPase MORC2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Tan, W, Shakeel, S. | | Deposit date: | 2024-06-25 | | Release date: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | MORC2 is a phosphorylation-dependent DNA compaction machine.
Nat Commun, 16, 2025
|
|
