7ORM
 
 | | La Crosse virus polymerase at transcription early-elongation stage | | Descriptor: | MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3'), RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*C)-3'), ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2022-03-02 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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7ORN
 | | La Crosse virus polymerase at replication initiation stage | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, La Crosse virus polymerase, MAGNESIUM ION, ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2022-03-02 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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7ORK
 | | La Crosse virus polymerase in transcription mode with cleaved capped RNA entering the polymerase active site | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (5'-D(*(GTG))-R(P*A)-3'), ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2022-03-02 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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7ORL
 | | La Crosse virus polymerase at transcription initiation stage | | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2022-03-02 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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2JDQ
 | | C-terminal domain of influenza A virus polymerase PB2 subunit in complex with human importin alpha5 | | Descriptor: | IMPORTIN ALPHA-1 SUBUNIT, POLYMERASE BASIC PROTEIN 2 | | Authors: | Tarendeau, F, Guilligay, D, Mas, P, Boulo, S, Baudin, F, Ruigrok, R.W.H, Hart, D.J, Cusack, S. | | Deposit date: | 2007-01-11 | | Release date: | 2007-02-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure and Nuclear Import Function of the C- Terminal Domain of Influenza Virus Polymerase Pb2 Subunit
Nat.Struct.Mol.Biol., 14, 2007
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2GMO
 | | NMR-structure of an independently folded C-terminal domain of influenza polymerase subunit PB2 | | Descriptor: | Polymerase basic protein 2 | | Authors: | Boudet, J, Tarendeau, F, Guilligay, D, Mas, P, Bougault, C.M, Cusack, S, Simorre, J.-P, Hart, D.J. | | Deposit date: | 2006-04-07 | | Release date: | 2007-02-27 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit.
Nat.Struct.Mol.Biol., 14, 2007
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6GGS
 | | Structure of RIP2 CARD filament | | Descriptor: | Receptor-interacting serine/threonine-protein kinase 2 | | Authors: | Pellegrini, E, Cusack, S, Desfosses, A, Schoehn, G, Malet, H, Gutsche, I, Sachse, C, Hons, M. | | Deposit date: | 2018-05-03 | | Release date: | 2018-10-17 | | Method: | ELECTRON MICROSCOPY (3.94 Å) | | Cite: | RIP2 filament formation is required for NOD2 dependent NF-kappa B signalling.
Nat Commun, 9, 2018
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6GFJ
 | | Structure of RIP2 CARD domain fused to crystallisable MBP tag | | Descriptor: | Sugar ABC transporter substrate-binding protein,Receptor-interacting serine/threonine-protein kinase 2, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Pellegrini, E, Cusack, S. | | Deposit date: | 2018-04-30 | | Release date: | 2019-03-13 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | RIP2 filament formation is required for NOD2 dependent NF-kappa B signalling.
Nat Commun, 9, 2018
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6T0S
 | | Bat Influenza A polymerase stuttering complex using 44-mer vRNA template with intact oligo(U) sequence | | Descriptor: | MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... | | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | | Deposit date: | 2019-10-03 | | Release date: | 2020-04-15 | | Last modified: | 2020-05-27 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
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6T0N
 | | Bat Influenza A polymerase pre-initiation complex | | Descriptor: | 3' vRNA, 5' vRNA, MAGNESIUM ION, ... | | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | | Deposit date: | 2019-10-03 | | Release date: | 2020-04-15 | | Last modified: | 2020-05-27 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
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6T0R
 | | Bat Influenza A polymerase product dissociation complex using 44-mer vRNA template with mutated oligo(U) sequence | | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit, ... | | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | | Deposit date: | 2019-10-03 | | Release date: | 2020-04-15 | | Last modified: | 2020-05-27 | | Method: | ELECTRON MICROSCOPY (2.82 Å) | | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
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6SZV
 | | Bat Influenza A polymerase elongation complex with incoming UTP analogue (core + endonuclease only) | | Descriptor: | 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... | | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | | Deposit date: | 2019-10-02 | | Release date: | 2020-04-15 | | Last modified: | 2020-05-27 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
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6T0U
 | | Bat Influenza A polymerase product dissociation complex using 44-mer vRNA template with intact oligo(U) sequence | | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit, ... | | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | | Deposit date: | 2019-10-03 | | Release date: | 2020-04-15 | | Last modified: | 2020-05-27 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
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6SZU
 | | Bat Influenza A polymerase pre-termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence | | Descriptor: | 5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | | Deposit date: | 2019-10-02 | | Release date: | 2020-04-15 | | Last modified: | 2020-05-27 | | Method: | ELECTRON MICROSCOPY (2.41 Å) | | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
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6T0V
 | | Bat Influenza A polymerase elongation complex with incoming UTP analogue (complete polymerase) | | Descriptor: | 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... | | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | | Deposit date: | 2019-10-03 | | Release date: | 2020-04-15 | | Last modified: | 2020-05-27 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
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6T0W
 | | Human Influenza B polymerase recycling complex | | Descriptor: | Polymerase PB2, Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, ... | | Authors: | Wandzik, J.M, Kouba, T, Karuppasamy, M, Cusack, S. | | Deposit date: | 2019-10-03 | | Release date: | 2020-04-15 | | Last modified: | 2020-05-27 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
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6T2C
 | | Bat Influenza A polymerase recycling complex | | Descriptor: | MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... | | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | | Deposit date: | 2019-10-08 | | Release date: | 2020-04-15 | | Last modified: | 2020-05-27 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
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6TW1
 | | Bat Influenza A polymerase termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence | | Descriptor: | 5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | | Deposit date: | 2020-01-11 | | Release date: | 2020-04-15 | | Last modified: | 2020-04-29 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 2020
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8AS6
 | | Structure of the SFTSV L protein bound to 5' cRNA hook [5' HOOK] | | Descriptor: | RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*C)-3'), RNA-dependent RNA-polymerase L protein | | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | Deposit date: | 2022-08-18 | | Release date: | 2023-01-18 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
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8ASB
 | | Structure of the SFTSV L protein stalled at early elongation with the endonuclease domain in a raised conformation [EARLY-ELONGATION-ENDO] | | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*A)-3'), ... | | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | Deposit date: | 2022-08-18 | | Release date: | 2023-01-18 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
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8AS7
 | | Structure of the SFTSV L protein stalled at early elongation [EARLY-ELONGATION] | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, ... | | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | Deposit date: | 2022-08-18 | | Release date: | 2023-01-18 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
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8ASD
 | | Structure of the SFTSV L protein stalled at late elongation [LATE-ELONGATION] | | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3'), ... | | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | Deposit date: | 2022-08-19 | | Release date: | 2023-01-18 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
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8ASG
 | | Structure of the SFTSV L protein bound in a resting state [RESTING] | | Descriptor: | MAGNESIUM ION, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*AP*UP*GP*A*)-3'), RNA (5'-R(*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U*)-3'), ... | | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | Deposit date: | 2022-08-19 | | Release date: | 2023-01-18 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
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1ZZJ
 | | Structure of the third KH domain of hnRNP K in complex with 15-mer ssDNA | | Descriptor: | 5'-D(*TP*TP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*TP*TP*T)-3', Heterogeneous nuclear ribonucleoprotein K | | Authors: | Backe, P.H, Messias, A.C, Ravelli, R.B, Sattler, M, Cusack, S. | | Deposit date: | 2005-06-14 | | Release date: | 2005-08-09 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | X-Ray Crystallographic and NMR Studies of the Third KH Domain of hnRNP K in Complex with Single-Stranded Nucleic Acids
STRUCTURE, 13, 2005
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1ZZK
 | | Crystal Structure of the third KH domain of hnRNP K at 0.95A resolution | | Descriptor: | Heterogeneous nuclear ribonucleoprotein K | | Authors: | Backe, P.H, Messias, A.C, Ravelli, R.B, Sattler, M, Cusack, S. | | Deposit date: | 2005-06-14 | | Release date: | 2005-08-09 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (0.95 Å) | | Cite: | X-Ray Crystallographic and NMR Studies of the Third KH Domain of hnRNP K in Complex with Single-Stranded Nucleic Acids
STRUCTURE, 13, 2005
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