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2FVN
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The fibrillar tip complex of the Afa/Dr adhesins from pathogen E. coli displays synergistic binding to 5 1 and v 3 integrins
分子名称: Protein afaD
著者Cota, E, Simpson, P, Anderson, K.L, Matthews, S.J.
登録日2006-01-31
公開日2007-02-27
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献The solution structure of the invasive tip complex from Afa/Dr fibrils
Mol.Microbiol., 62, 2006
2IXQ
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The solution structure of the invasive tip complex from Afa-Dr fibrils
分子名称: Afimbrial adhesin AFA-III, Protein AfaD
著者Cota, E, Jones, C, Simpson, P, Altroff, H, Anderson, K.L, du Merle, L, Guignot, J, Servin, A, Le Bouguenec, C, Mardon, H, Matthews, S.
登録日2006-07-10
公開日2006-09-20
最終更新日2018-12-05
実験手法SOLUTION NMR
主引用文献The solution structure of the invasive tip complex from Afa/Dr fibrils.
Mol. Microbiol., 62, 2006
4R1E
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BU of 4r1e by Molmil
Crystal Structure of MTIP from Plasmodium falciparum in complex with a peptide-fragment chimera
分子名称: 5-{[(2-aminoethyl)sulfanyl]methyl}furan-2-carbaldehyde, Myosin A tail domain interacting protein, Myosin-A
著者Douse, C.H, Vrielink, N, Cota, E, Tate, E.W.
登録日2014-08-05
公開日2014-11-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Targeting a Dynamic Protein-Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex.
Chemmedchem, 10, 2015
6HUF
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Coping with strong translational non-crystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-27A
著者Jamshidiha, M, Perez-Dorado, I, Murray, J.W, Tate, E.W, Cota, E, Read, R.J.
登録日2018-10-08
公開日2019-03-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Coping with strong translational noncrystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a.
Acta Crystallogr D Struct Biol, 75, 2019
7OPP
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Crystal structure of the Rab27a fusion with Slp2a-RBDa1 effector for SF4 pocket drug targeting
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Synaptotagmin-like protein 2,Ras-related protein Rab-27A
著者Jamshidiha, M, Tersa, M, Lanyon-Hogg, T, Perez-Dorado, I, Sutherell, C.L, De Vita, E, Morgan, R.M.L, Tate, E.W, Cota, E.
登録日2021-06-01
公開日2022-04-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Rsc Med Chem, 13, 2022
7OPR
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Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CB1 in C123
分子名称: GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Jamshidiha, M, Tersa, M, Lanyon-Hogg, T, Perez-Dorado, I, Sutherell, C.L, De Vita, E, Morgan, R.M.L, Tate, E.W, Cota, E.
登録日2021-06-01
公開日2022-04-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Rsc Med Chem, 13, 2022
7OPQ
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Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CA1 in C188
分子名称: 1-[(2~{S})-2-(4-methoxyphenyl)pyrrolidin-1-yl]propan-1-one, GLYCEROL, MAGNESIUM ION, ...
著者Jamshidiha, M, Tersa, M, Lanyon-Hogg, T, Perez-Dorado, I, Sutherell, C.L, De Vita, E, Morgan, R.M.L, Tate, E.W, Cota, E.
登録日2021-06-01
公開日2022-04-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Rsc Med Chem, 13, 2022
1USQ
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Complex of E. Coli DraE adhesin with Chloramphenicol
分子名称: 1,2-ETHANEDIOL, CHLORAMPHENICOL, DR HEMAGGLUTININ STRUCTURAL SUBUNIT, ...
著者Anderson, K.L, Billington, J, Pettigrew, D, Cota, E, Roversi, P, Simpson, P, Chen, H.A, Urvil, P, Dumerle, L, Barlow, P, Medof, E, Smith, R.A.G, Nowicki, B, Le Bouguenec, C, Lea, S.M, Matthews, S.
登録日2003-11-27
公開日2004-08-31
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献High Resolution Studies of the Afa/Dr Adhesin Drae and its Interaction with Chloramphenicol
J.Biol.Chem., 279, 2004
1USZ
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SeMet AfaE-3 adhesin from Escherichia Coli
分子名称: AFIMBRIAL ADHESIN AFA-III, CHLORIDE ION, SULFATE ION
著者Anderson, K.L, Billington, J, Pettigrew, D, Cota, E, Roversi, P, Simpson, P, Chen, H.A, Urvil, P, Dumerle, L, Barlow, P, Medof, E, Smith, R.A.G, Nowicki, B, Le Bouguenec, C, Lea, S.M, Matthews, S.
登録日2003-12-02
公開日2004-08-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.28 Å)
主引用文献High Resolution Studies of the Afa/Dr Adhesin Drae and its Interaction with Chloramphenicol
J.Biol.Chem., 279, 2004
1UT1
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DraE adhesin from Escherichia Coli
分子名称: 1,2-ETHANEDIOL, DR HEMAGGLUTININ STRUCTURAL SUBUNIT, SULFATE ION
著者Anderson, K.L, Billington, J, Pettigrew, D, Cota, E, Roversi, P, Simpson, P, Chen, H.A, Urvil, P, Dumerle, L, Barlow, P, Medof, E, Smith, R.A.G, Nowicki, B, Le Bouguenec, C, Lea, S.M, Matthews, S.
登録日2003-12-02
公開日2004-08-31
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献High Resolution Studies of the Afa/Dr Adhesin Drae and its Interaction with Chloramphenicol
J.Biol.Chem., 279, 2004
1UT2
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AfaE-3 adhesin from Escherichia Coli
分子名称: AFIMBRIAL ADHESIN AFA-III, SULFATE ION
著者Anderson, K.L, Billington, J, Pettigrew, D, Cota, E, Roversi, P, Simpson, P, Chen, H.A, Urvil, P, Dumerle, L, Barlow, P, Medof, E, Smith, R.A.G, Nowicki, B, Le Bouguenec, C, Lea, S.M, Matthews, S.
登録日2003-12-02
公開日2004-08-31
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献High Resolution Studies of the Afa/Dr Adhesin Drae and its Interaction with Chloramphenicol
J.Biol.Chem., 279, 2004
2BVB
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BU of 2bvb by Molmil
The C-terminal domain from Micronemal Protein 1 (MIC1) from Toxoplasma Gondii
分子名称: MICRONEMAL PROTEIN 1
著者Saouros, S, Edwards-Jones, B, Reiss, M, Sawmynaden, K, Cota, E, Simpson, P, Dowse, T.J, Jakle, U, Ramboarina, S, Shivarattan, T, Matthews, S, Soldati-Favre, D.
登録日2005-06-23
公開日2005-10-12
最終更新日2021-06-23
実験手法SOLUTION NMR
主引用文献A Novel Galectin-Like Domain from Toxoplasma Gondll Micronemal Protein 1 Assists the Folding, Assembly,and Transport of a Cell-Adhesion Complex.
J.Biol.Chem., 280, 2005
1RXL
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Solution structure of the engineered protein Afae-dsc
分子名称: Afimbrial adhesin AFA-III
著者Anderson, K.L, Billington, J, Pettigrew, D, Cota, E, Roversi, P, Simpson, P, Chen, H.A, Urvil, P, du Merle, L, Barlow, P.N, Medof, M.E, Smith, R.A, Nowicki, B, Le Bouguenec, C, Lea, S.M, Matthews, S.
登録日2003-12-18
公開日2005-01-11
最終更新日2020-02-05
実験手法SOLUTION NMR
主引用文献An atomic resolution model for assembly, architecture, and function of the Dr adhesins.
Mol.Cell, 15, 2004
6FCO
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Structural and functional characterisation of Frataxin (FXN) like protein from Chaetomium thermophilum
分子名称: MALONIC ACID, Mitochondrial frataxin-like protein
著者Jamshidiha, M, Rasheed, M, Pastore, A, Cota, E.
登録日2017-12-20
公開日2019-01-23
最終更新日2019-02-13
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Structural and functional characterization of a frataxin from a thermophilic organism.
FEBS J., 286, 2019
2MPV
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Structural insight into host recognition and biofilm formation by aggregative adherence fimbriae of enteroaggregative Esherichia coli
分子名称: Major fimbrial subunit of aggregative adherence fimbria II AafA
著者Matthews, S.J, Yang, Y, Berry, A.A, Pakharukova, N, Garnett, J.A, Lee, W, Cota, E, Liu, B, Roy, S, Tuittila, M, Marchant, J, Inman, K.G, Ruiz-Perez, F, Mandomando, I, Nataro, J.P, Zavialov, A.V.
登録日2014-06-04
公開日2014-10-29
実験手法SOLUTION NMR
主引用文献Structural insight into host recognition by aggregative adherence fimbriae of enteroaggregative Escherichia coli.
Plos Pathog., 10, 2014
2Y2Y
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Oxidised form of E. coli CsgC
分子名称: ACETATE ION, CURLI PRODUCTION PROTEIN CSGC
著者Taylor, J.D, Salgado, P.S, Constable, S.C, Cota, E, Mathews, S.J.
登録日2010-12-16
公開日2011-09-21
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Atomic Resolution Insights Into Curli Fiber Biogenesis.
Structure, 19, 2011
2Y2T
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E. coli CsgC in reduced form
分子名称: CURLI PRODUCTION PROTEIN CSGC
著者Taylor, J.D, Salgado, P.S, Cota, E, Matthews, S.J.
登録日2010-12-16
公開日2011-09-21
最終更新日2017-07-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Atomic Resolution Insights Into Curli Fiber Biogenesis.
Structure, 19, 2011
4AOM
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MTIP and MyoA complex
分子名称: MYOSIN A TAIL DOMAIN INTERACTING PROTEIN, MYOSIN-A
著者Salgado, P.S, Douse, C.H, Simpson, P.J, Thomas, J.C, Holder, A.A, Tate, E.W, Cota, E.
登録日2012-03-29
公開日2012-09-05
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.939 Å)
主引用文献Regulation of the Plasmodium Motor Complex: Phosphorylation of Myosin a Tail Interacting Protein (Mtip) Loosens its Grip on Myoa
J.Biol.Chem., 287, 2012
2VER
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Structural model for the complex between the Dr adhesins and carcinoembryonic antigen (CEA)
分子名称: AFIMBRIAL ADHESIN AFA-III, ARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
著者Korotkova, N, Yang, Y, Le Trong, I, Cota, E, Demeler, B, Marchant, J, Thomas, W.E, Stenkamp, R.E, Moseley, S.L, Matthews, S.
登録日2007-10-26
公開日2008-01-08
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Binding of Dr Adhesins of Escherichia Coli to Carcinoembryonic Antigen Triggers Receptor Dissociation.
Mol.Microbiol., 67, 2008
2XSK
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E. coli curli protein CsgC - SeCys
分子名称: ACETATE ION, CSGC
著者Salgado, P.S, Taylor, J.D, Cota, E, Matthews, S.J.
登録日2010-09-29
公開日2010-12-29
最終更新日2014-01-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Extending the Usability of the Phasing Power of Diselenide Bonds: Secys Sad Phasing of Csgc Using a Non-Auxotrophic Strain.
Acta Crystallogr.,Sect.D, 67, 2011
2WNM
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Solution structure of Gp2
分子名称: GENE 2
著者Camara, B, Liu, M, Shadrinc, A, Liu, B, Simpson, P, Weinzierl, R, Severinovc, K, Cota, E, Matthews, S, Wigneshweraraj, S.R.
登録日2009-07-13
公開日2010-02-16
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献T7 Phage Protein Gp2 Inhibits the Escherichia Coli RNA Polymerase by Antagonizing Stable DNA Strand Separation Near the Transcription Start Site.
Proc.Natl.Acad.Sci.USA, 107, 2010
4LEB
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Structure of the Als3 adhesin from Candida albicans, residues 1-299 (mature sequence) in complex with hepta-threonine
分子名称: Agglutinin-like protein 3, hepta-threonine
著者Lin, J, Garnett, J.A, Cota, E.
登録日2013-06-25
公開日2014-05-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献The Peptide-binding Cavity Is Essential for Als3-mediated Adhesion of Candida albicans to Human Cells.
J.Biol.Chem., 289, 2014
4LE8
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Structure of the Als3 adhesin from Candida albicans, residues 1-299 (mature sequence)
分子名称: Agglutinin-like protein 3
著者Lin, J, Garnett, J.A, Cota, E.
登録日2013-06-25
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The peptide binding mechanism of Als3 mediates early attachment of Candida albicans to host cells
To be Published
4LEE
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Structure of the Als3 adhesin from Candida albicans, residues 1-313 (mature sequence), triple mutant in the binding cavity: K59M, A116V, Y301F
分子名称: Agglutinin-like protein 3
著者Lin, J, Garnett, J.A, Cota, E.
登録日2013-06-25
公開日2014-05-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The Peptide-binding Cavity Is Essential for Als3-mediated Adhesion of Candida albicans to Human Cells.
J.Biol.Chem., 289, 2014
4MZL
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Crystal Structure of MTIP from Plasmodium falciparum in complex with HBS myoA, a hydrogen bond surrogate myoA helix mimetic
分子名称: Myosin A tail domain interacting protein, hydrogen bond surrogate (HBS) myoA helix mimetic
著者Douse, C.H, Garnett, J.A, Maas, S.J, Cota, E, Tate, E.W.
登録日2013-09-30
公開日2013-11-06
最終更新日2023-06-07
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein-Helix Interaction.
Acs Chem.Biol., 8, 2014

 

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